The 700th birth anniversary of King of Bohemia and Holy Roman Emperor Charles IV has been designated as one of UNESCO´s important world anniversaries for 2016-2017. The Czech Academy of Sciences recreates the period of Charles IV at the exhibiton entitled Seven Towers. Charles IV through the eyes of academics (1316-2016) at the Science and Art Gallery. The visitors have an oppportunity to see the unique gold ducats with a picture of Charles IV. For this first time the most valuable archaeological discoveries of glass goblets are exhibited. Everyday items used by residents of the medieval city are also on display. The exhibition also shows a rare treasure of coins, which was hidden in the Emmaus monastery about 1370, as well as copies of the Constitutive Act of the Charles University, Charles´s Code Maiestas Carolina or late-medieval transcript of Charles´ Golden Bull. Personality of Charles IV is documented by commemorative coins, medals and seals bearing his image. Part of the exhibition is also a faithful copy of the statue of Charles IV from the Old Town Bridge Tower, the last sculptural portrait of the monarch before his death. and Marina Hužvárová.
Acrylamide (AA) is a highly reactive organic compound capable of polymerization to form polyacrylamide, which is commonly used throughout a variety of industries. Given its toxic effect on humans and animals, the last 20 years have seen an increased interest in research devoted to the AA. One of the main sources of AA is food. AA appears in heated food following the reaction between amino acids and reduced sugars. Large concentrations of AA can be found in popular staples such as coffee, bread or potato products. An average daily consumption of AA is between 0.3-2.0 μg/kg b.w. Inhalation of acrylamide is related with occupational exposure. AA delivered with food is metabolized in the liver by cytochrome P450. AA biotransformation and elimination result in formation of toxic glycidamide (GA). Both, AA and GA can be involved in the coupling reaction with the reduced glutathione (GSH) forming glutathione conjugates which are excreted with urine. Biotransformation of AA leads to the disturbance in the redox balance. Numerous research proved that AA and GA have significant influence on physiological functions including signal propagation in peripheral nerves, enzymatic and hormonal regulation, functions of muscles, reproduction etc. In addition AA and GA show neurotoxic, genotoxic and cancerogenic properties. In 1994, International Agency for Research on Cancer (IARC) classified acrylamide as a potentially carcinogenic substance to human., M. Semla, Z. Goc, M. Martiniaková, R. Omelka, G. Formicki., and Obsahuje bibliografii
The function of adult neurogenesis in the dentate gyrus is not yet completely understood, though many competing theories have attempted to explain the function of these newly -generated neurons. Most theories give adult neurogenesis a role in aiding known hippocampal/dentate gyrus functions. Other theories offer a novel role for these new cells based on their unique physiological qualities, such as their low excitability threshold. Many behavioral tests have been used to test these theories, but results have been inconsistent and often contradictory. Substantial variability in tests and protocols may be at least partially responsible for the mixed results. On the other hand, conflicting results arising from the same tests can serve as aids in elucidating the function of adult neurogenesis. Here, we offer a hypothesis that considers the cognitive nature of tasks commonly used to assess the function of adult neurogenesis, and introduce a dichotomy between tasks focused on discrimination vs. generalization. We view these two aspects as opposite ends of the continuous spectrum onto which traditional tests can be mapped. We propose that high neurogenesis favors behavioral discrimination while low adult neurogenesis favors behavioral generalization of a knowledge or rule. Since many tasks require both, the effects of neurogenesis could be cancelled out in many cases. Although speculative, we hope that our view presents an interesting and testable hypothesis of the effect of adult neurogenesis in traditional behavioral tasks. We conclude that new, carefully designed behavioral tests may be necessary to reach a final consensus on the role of adult neurogenesis in behavior., A. Pistikova, H. Brozka, A. Stuchlik., and Obsahuje bibliografii
Accumulating evidence indicates that hypertension is associated with "ion channel remodeling" of vascular smooth muscle cells (VSMCs). The objective of this study was to determine the effects of exercise intensity/volume on hypertension-associated changes in large-conductance Ca2+-activated K+ (BKCa) channels in mesenteric arteries (MAs) from spontaneously hypertensive rats (SHR). Male SHRs were randomly assigned to three groups: a low-intensity aerobic exercise group (SHR-L: 14 m/min), a moderate-intensity aerobic exercise group (SHR-M: 20 m/min), and a sedentary group (SHR). Age-matched Wistar-Kyoto rats (WKYs) were used as normotensive controls. Exercise groups completed an 8-week exercise program. Elevation of the α and β1 proteins was unequal in MA myocytes from SHRs, with the β1 subunit increasing more than the α subunit. BKCa contribution to vascular tone regulation was higher in the myocytes and arteries of SHRs compared to WKYs. SHR BKCa channel subunit protein expression, β1/α ratio, whole cell current density and single-channel open probability was also increased compared with WKYs. Aerobic exercise lowered systemic blood pressure and normalized hypertension-associated BKCa alterations to normotensive control levels in the SHRs. These effects were more pronounced in the moderate-intensity group than in the low-intensity group. There is a dose-effect for aerobic exercise training in the range of low to moderate-intensity and accompanying volume for the correction of the pathological adaptation of BKCa channels in myocytes of MAs from SHR., Y. Zhang, Y. Chen, L. Zhang, N. Lu, L. Shi., and Obsahuje bibliografii
CD163 is a marker of macrophages with anti-inflammatory properties and its soluble form (sCD163) is considered a prognostic predictor of several diseases including type 2 diabetes mellitus (T2DM). We explored sCD163 levels at baseline and after very low-calorie diet (VLCD) or bariatric surgery in 32 patients with obesity (20 undergoing VLCD and 12 bariatric surgery), 32 obese patients with T2DM (22 undergoing VLCD and 10 bariatric surgery), and 19 control subjects. We also assessed the changes of CD163 positive cells of monocyte-macrophage lineage in peripheral blood and subcutaneous adipose tissue (SAT) in subset of patients. Plasma sCD163 levels were increased in obese and T2DM subjects relative to control subjects (467.2±40.2 and 513.8±37.0 vs. 334.4±24.8 ng/ml, p=0.001) and decreased after both interventions. Obesity decreased percentage of CD163+CD14+ monocytes in peripheral blood compared to controls (78.9±1.48 vs. 86.2±1.31 %, p=0.003) and bariatric surgery decreased CD163+CD14+HLA-DR+ macrophages in SAT (19.4±2.32 vs. 11.3±0.90 %, p=0.004). Our data suggest that increased basal sCD163 levels are related to obesity and its metabolic complications. On the contrary, sCD163 or CD163 positive cell changes do not precisely reflect metabolic improvements after weight loss., A. Cinkajzlová, Z. Lacinová, J. Kloučková, P. Kaválková, P. Trachta, M. Kosák, J. Krátký, M. Kasalický, K. Doležalová, M. Mráz, M. Haluzík., and Obsahuje bibliografii
The velocities of the Global Positioning System (GPS) stations are widely employed for numerous geodynamical studies. The aim of this paper is to investigate the reliability of station velocities and to draw reader’s attention that for proper estimates of velocity, we need to consider the optimal character of noise. We focus on a set of 115 European GPS stations which contributed to the newest release of the International Terrestrial Reference Frame (ITRF), i.e. ITRF2014. Based on stacked Power Spectral Densities (PSDs), we show that amplitudes o f seasonal signals are significant for nine harmonics of tropical year (365.25 days) and two harmonics of draconitic year (351.60 days). The amplitudes of tropical annual signal fall between 0.1-8.4 mm and are much higher for vertical component than for horizontal. Draconitic annual signal reaches the maximum amplitudes of 1.2 and 0.9 mm for North and East, respectively, whereas is slightly higher for the Up component with a maximum of 3.1 mm. We performed a noise analysis with Maximum Like lihood Estimation (MLE) and found that stations in Central and Northern Europe are characterized by spectral index between flicker and random-walk noise, while stations in Southern and Western Europe: between white and flicker noise. Both amplitudes and spectral indices of power-law noise show a spatial correlation for Up component. We compared the uncertainties of velocities derived in this study with a combination of power-law and white noises to the ones offici ally released in the ITRF2014 with a pure white noise. A ratio of the two estimates is larger than 10 for 13 % and 30 % of stations in horizontal and vertical direction, respectively with medians of 6 and 7. The large differences support the fact that at the velocity determination the proper noise characteristic should be taken into account to avoid any mislead interpretation., Anna Klos and Janusz Bogusz., and Obsahuje bibliografické odkazy
Water is one of the most important components of the environment, having a direct effect on the maintenance of life on the Earth. In this paper, analysis of groundwater level variations, water balance and all the parameters included in these quantities, i.e. precipitation, evapotranspiration, surface run-off and subsurface run-off, were performed in the area of the Sudety Mountains for the period of November 2002 - October 2015. The groundwater level variations were computed on the basis of the mean Terrestrial Water Storage (TWS) values determined from Gravity Recovery and Climate Experiment (GRACE) observations and Global Land Data Assimilation System (GLD AS). TWS data have been determined with a spatial resolution of one degree and temporal resolution of one month. According to the results, groundwater level variation can be approximately determined by water balance changes (with reverse sign). Specifically, for the Sudety area a high average stability of total water storage over the period of past 13 years and decline in groundwater level by about 13 cm (approximately 1 cm/year) was detected., Zofia Rzepecka, Monika Birylo, Joanna Kuczynska-Siehien, Jolanta Nastula and Katarzyna Pajak., and Obsahuje bibliografické odkazy
High temperature alters the internal microstructure of rocks and consequently changes the physical and mechanical properties of rocks. Many studies have been carried out to examine the transformations in the microstructures of rocks under high temperature through near infrared spectroscopy (NIR), Raman spectroscopy, or thermo gravimetric analysis (TGA). The current review synthesizes the data from a number of literatures and summarizes the major transformations of silica rocks under high temperature. The analysis shows that silica rocks starts to lose the water adsorbed in open pores upon heating at about 150 °C. At 200-300 °C, the reaction between SiOH (silanole) in the rocks generates new Si-O-Si bonds as well as H2O, and decreases the open pores. The rocks undergo volume expansion at >550 °C, and the volume contracts and forms new micro pores or cracks which play an important role in the evacuation of the water., Jishi Geng, Qiang Sun, Yuchun Zhang and Yuliang Zhang., and Obsahuje bibliografické odkazy
Hemolytic uremic syndrome (HUS) is a type of thrombotic microangiopathy, in the course of which some patients may develop chronic kidney disease (CKD). It is clinically important to investigate the markers of a poor prognosis. The levels of angiotensinogen (AGT) and interleukin-18 (IL-18) in serum and urine were evaluated. Study was conducted in 29 children with a history of HUS. Serum and urine AGT concentration was significantly higher in children after HUS as compared to the control group. No differences depending on the type of HUS and gender were noted. The serum concentration of IL-18 in children after HUS was significantly lower, whereas in urine did not differ significantly between the sick and healthy children. A negative correlation between the concentration of AGT in serum and albuminuria in patients after HUS was detected. The results indicate that the concentration of AGT in serum and urine in children after HUS increases, which may indicate the activation of the intrarenal renin-angiotensin-aldosterone system. The statement, that AGT may be a good biomarker of CKD after acute kidney injury due to HUS requires prospective studies with follow-up from the acute phase of the disease on a larger group of patients. Reduced IL-18 serum concentration in children after HUS with no difference in its urine concentration may indicate a loss of the protective effects of this cytokine on renal function due to previously occurred HUS., K. Lipiec, P. Adamczyk, E. Świętochowska, K. Ziora, M. Szczepańska., and Obsahuje bibliografii