Cognitive functions and drug sensitivity in adult male rats prenatally exposed to methamphetamine

Title:

Cognitive functions and drug sensitivity in adult male rats prenatally exposed to methamphetamine

Creator:

Barbora Schutová, Hrubá, L., Marie Pometlová, Deykun, K., and Romana Šlamberová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:d9304eaf-1913-4c53-b363-5dced04695bf
uuid:d9304eaf-1913-4c53-b363-5dced04695bf

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, pervitin, prostorová orientace, physiology, methamphetamine, spatial orientation, Morrisovo vodní bludiště, senzitizace, Morris water maze, sensitization, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

The aim of the present study was to investigate the impact of prenatal methamphetamine (MA) exposure and application of the same drug in adulthood on cognitive functions of adult male rats tested in Morris water maze (MWM). Adult male rats prenatally exposed to MA (5 mg/kg), saline or no injection were examined. Half of the animals were injected daily with MA (1 mg/kg) after finishing the testing. Three types of tests were used: (1) “Place navigation test” (Learning), (2) “Probe test” and (3) “Retention memory test” (Memory). Our results showed that prenatal MA exposure did not affect the test of learning and the Probe test. In the test of memory prenatally MA-exposed rats showed smaller search errors and used spatial strategies more than both control groups. Further, MA application in adulthood prolonged trajectories, increased the incidence of random search and decreased the incidence of direct swim in the Place navigation test. In addition, MA administration in adulthood increased the speed of swimming regardless of prenatal exposure. The present study thus demonstrates that 1) Prenatal MA exposure does not affect learning in the MWM, 2) Prenatal MA exposure improves performance in the Retention memory test in the MWM, and 3) MA application in adulthood impairs learning in the Morris water maze., B. Schutová ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:5

Harvested from:

CDK

Metadata only:

false