In this paper, I propose a programme for future critical responses to naturalism. The paper is divided into two principal parts. In Part I, after providing a topography of contemporary critical approaches to the Placement Problem, which is the operational logic of naturalism, I provide an overview of a burgeoning critical response to naturalism, which, to date, may be predominantly individuated by hostility towards the Placement Problem in two interconnected manners: an epistemic concern and a political concern. Part II of the paper focuses on four areas of future research on critical responses to naturalism arising from themes identified in Part I: the first is a challenge set by Antonio Nunziante concerning the historical and political aspects of American humanism and naturalism; the second involves centring and combining decolonial and queer theoretic discursive formations to enhance critical theoretic responses to naturalism; the third emphasises the need to put Hegel and Otto Neurath in direct conversation about anti-foundationalism, pragmatism, and the (dis)unity of science, in part to dismantle the long-standing hostility between Hegelians and logical empiricists; the fourth is on the subject of developing a critique of sexology’s scientific naturalist framework for making sense of sexual arousal.