This study shows a comprehensive simulation of water and sediment fluxes from the catchment to the reach scale. We describe the application of a modelling cascade in a well researched study catchment through connecting stateof-the-art public domain models in ArcGIS. Three models are used consecutively: (1) the hydrological model SWAT to evaluate water balances, sediment input from fields and tile drains as a function of catchment characteristics; (2) the onedimensional hydraulic model HEC-RAS to depict channel erosion and sedimentation along a 9 km channel onedimensionally; and (3) the two-dimensional hydraulic model AdH for simulating detailed substrate changes in a 230 m long reach section over the course of one year. Model performance for the water fluxes is very good, sediment fluxes and substrate changes are simulated with good agreement to observed data. Improvement of tile drain sediment load, simulation of different substrate deposition events and carrying out data sensitivity tests are suggested as future work. Main advantages that can be deduced from this study are separate representation of field, drain and bank erosion processes; shown adaptability to lowland catchments and transferability to other catchments; usability of the model’s output for habitat assessments.