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12. Midazolam and its effect on vital signs and behavior in children under conscious sedation in dentistry

Creator:
Vašáková, Jana, Dušková, Jana, Lunackova, Jitka, Drapalova, Klara, Zuzankova, Lucie, Stárka, Luboslav, Dušková, Michaela, and Broukal, Zdeněk
Format:
počítač and online zdroj
Type:
model:article and TEXT
Subject:
děti, midazolam, children, conscious sedation, vital signs, dentistry, 14, and 612
Language:
English
Description:
Midazolam is a short acting sedative with small number of adverse effects. Administered orally, it is currently the most common form of conscious sedation in children. The objective of this paper is to describe effect of midazolam administered to children during dental treatment on their vital signs, and to monitor changes in children’s behavior. We described values of vital signs and behavior in 418 sedations conducted in 272 children between 1-12 years of age. To achieve the following results, we used data from 272 all first-time sedations. After administration of midazolam arterial blood pressure and blood oxygen saturation decreased by values which were not clinically significant. The heart rate increased, with values staying within the limits of physiological range. The speed of onset of midazolam’s clinical effects depends on age and dose. The lower age and dose correlated with the higher behavior score. The effectiveness of midazolam treatment is 97.8 %. Unwillingness of child to receive midazolam is predictor for disruptive behavior during sedation. 1.8 % of all sedation cases showed paradoxical reactions. The administration of midazolam in dose of 0.5 mg per 1 kg of child’s body weight is safe and could be recommended for dental treatment in pediatric dentistry., Jana Vasakova, Jana Duskova, Jitka Lunackova, Klara Drapalova, Lucie Zuzankova, Luboslav Starka, Michaela Duskova, Zdenek Broukal., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

14. Steroid diagnostics of 21st century in the light of their new roles and analytical tools

Creator:
Dušková, Michaela, Kolátorová Sosvorová, Lucie, Šimková, Markéta, Šrámková, Monika, Malíková, Mária, Horáčková, Lenka, Vítků, Jana, and Stárka, Luboslav
Format:
počítač and online zdroj
Type:
model:article and TEXT
Subject:
estrogeny, estrogens, pre-analytical phase, age differences, lesscommon steroids, LC-MS/MS, 14, and 612
Language:
English
Description:
The determination of steroid hormones and subsequent interpretation of results is accompanied by a range of difficulties. The amount of information that current technology can provide on the circulating concentrations of more than a hundred various steroid compounds can lead to problems with interpretation. The aim of this study is to help provide orientation in this maze of data on steroid hormones. First we focus on specific aspects arising from the pre-analytical phase of steroid determination that need to be considered when planning sampling, whether for diagnostics or research. Then, we provide a brief summary of the characteristics and diagnostic relevance of several steroid hormones and/or their metabolites: pregnenolone, 17α-hydroxypregnenolone, dehydroepiandrosterone, hydroxyderivatives of dehydroepiandrosterone, androstenedione, testosterone, estrone, estradiol, estriol, cortisol, cortisone, which in our institute are determined with validated LC-MS/MS methods. For these steroids, we also provide newly calculated reference values in fertile women according to the phase of their menstrual cycle and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

15. What is a hormone?

Creator:
Stárka, Luboslav and Dušková, Michaela
Format:
počítač and online zdroj
Type:
model:article and TEXT
Subject:
cytokiny, růstové faktory, cytokines, growth factors, hormone definition, erythropoietin, lipocalin-2, asprosin, fibroblast growth factor 23, 14, and 612
Language:
English
Description:
Starling’s original definition of a hormone from 1905 was “a hormone is a substance produced by glands with internal secretion, which serve to carry signals through the blood to target organs”. Today, this definition is understood to be lacking, but newer definitions also do not encompass the entire meaning of hormones as specific carriers of information. One main problem is that there is no delineation between hormones and other signaling molecules such as cytokines, growth factors or autacoid compounds. It seems that a precise definition is not even possible, since some cytokines and growth factors, such as the cytokines erythropoietin, lipocalin-2 and asprosin or fibroblast growth factor 23, act as hormones under certain conditions., Luboslav Stárka, Michaela Dušková., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public