The article investigates how the Holocaust distorted and exploited in Cold War debates on the example of genesis and reception of the book Ghetto Warschau. Tagebücher aus dem Chaos [Warsaw Ghetto: Diaries from Chaos]. The book is a translation of the essay Stosunki polsko-żydowskie w czasie drugiej wojny światowej [Polish-Jewish relations during the Second World War], written by the Jewish historian and creator of the underground archive of the Warsaw Ghetto Emanuel Ringelblum while hiding from the German Occupiers in Warsaw in 1944. Ringelblum addressed his essay to the Polish reader discussing the relation of Christian Poles and Polish Jews under German occupation based on his own experience and the material he had collected. It was originally published in several portions in the Bulletin of the Jewish Historical Institute, an early Holocaust Research Center based in Warsaw. The German translation was based on this publication and published in summer 1967 in a Stuttgart-based publishing house. However, the new title, introduced by its German editors, suggested it was Ringelblum’s diary. Above that the blurb and many footnotes highlighted the role of Poles as perpetrators in the Holocaust, while minimizing that of Germans. As the article shows, the book was prepared by the Göttinger Arbeitskreis ostdeutscher Wissenschaftler [Göttingen Working Group of Eastern German Scholars], a Think Tank with close ties to the German expellee community, campaigning for a revision of the Polish western border. Göttinger Arbeitskries used the book and earlier on excerpts of Ringelblum’s text for a smear-campaign in the West-German expellee press. Through the biased presentation and distorted context of the work these former Ostforschers sought to portrait Poles as eternal anti-Semites and the factual perpetrators of the mass murder of Polish and European Jews following their anti-Polish agenda. Polish nationalist within the ruling Polish United Workers Party in turn exploited the book and the campaign based on it, which coincided with the anti-Semitic campaign in Poland. Though the Institute was not involved in the publication of the German book, the Polish national communists accused it of supporting German revisionism and ''Zionists'' abroad in their slander of Poland. and Přeložil: David Dichelle
Social policy in the Protectorate of Bohemia and Moravia, from mid-March 1939 to early May 1945, is a key topic in contemporary research on the history of this brief period. The article is concerned with the possible approaches to research with regard to the latest trends in research on National Socialism. It begins with an outline of the historiography of social policy in the Protectorate, which is marked chiefl y by a predominant uniformity of argumentation, a lack of systematic approach to interpretation, and Czech and Czechoslovak historians’ limiting themselves to the ethnically Czech population. Research conducted so far has completely failed to put social policy into the context of social history. The author thus fi rst provides an outline of the social framework, which represents the concept of a Volksgemeinschaft (national/ethnic/racial community), in which ideas about the purpose and function of social policy were formed and implemented. In the next part, she focuses on the defi nition of the term ''social policy'' as understood by Nazi theorists after 1933. In the last part of the article, she seeks to defi ne the new social relations in the CzechGerman environment of the Protectorate of Bohemia and Moravia, and suggests possibilities of its analysis in the area of the implementation of social policy. She believes that it will be fruitful to study the implementation of the relevant criteria in the Reich and the Protectorate at the level of discussions among experts, and to research social policy in practice. The author sees the most important aspects of the implementation of social policy as residing in the various motivations of the regime when implementing social policy in relation to different parts of the population, ranging from social exclusion to forms of social protectionism.
The study deals with political activities of the Soviet Army in Czechoslovakia after the intervention on August 21, 1968, and its sympathizers from the ranks of the Communist Party of Czechoslovakia. The authoress examines the topic in the early stage of the so-called normalization (until the spring of 1970), focusing on the local level; however, she sets her research into a broader period context and derives general conclusions from its results. Although the offi cial agreement on the temporary stay of Soviet troops in the territory of Czechoslovakia declared that the Soviet Army should not interfere with domestic affairs of the Czechoslovak state, the Soviet leadership kept devising plans how to make use of the presence of Soviet troops for political purposes. Soviet offi cers participated in the dissemination of Soviet propaganda, established contacts with local anti-reform party offi cials, spoke at their forums, complained about hostile attitudes of Czechoslovak political bodies, and thus kept pressing for a legitimization of the political arrangements. The authoress shows that local pro-Soviet activists, who had maintained contacts with the Soviet Army from the very beginning and been taking over its political agenda, were playing a crucial role in the success of these efforts. In line with Soviet intentions, they were implementing the normalization process ''from below'',initiating purges in various organs, demanding the dismissal of offi cials protesting against presence of the Soviet Army, participating in the subsequent political vetting. They were actively pushing through a change of the offi cial approach to the Soviet Army and helped break its boycott by the Czechoslovak society, which had initially been almost unanimous. In doing so, they were making use of their personal contacts to organize manifestation ''friendship'' meetings and visits of Soviet soldiers to Czechoslovak schools and factories. The authoress analyzes the reasons of the attitude of these activists, most of whom came from the ranks of ''old'' (pre-war) and ''distinguished'' members of the Communist Party of Czechoslovakia, and illustrates the development outlined above by specifi c examples. By way of conclusion, she notes that, although different forms of the CzechoslovakSoviet ''friendship'' since 1968 are often viewed as mere formalistic acts without any deeper meaning at the level of ''lived'' experience, they were, from the viewpoint of the Soviet policy, well thought-out and centrally planned propagandistic activities which contributed to the promotion of the Soviet interpretation of the Prague Spring and the Soviet invasion and discredited its opponents. and Přeložila Blanka Medková
Homeownership has been in decline in a number of developed societies since the early 2000s driven, primarily, by declining entry among younger households who have been increasingly pushed into the rental sector. This trend has been associated with a growing intergenerational divide, or even conflict, and the emergence of ‘Generation Rent’. This paper explores the conditions surrounding diminishing access to owner-occupation among new households with a focus on the historic maturation of homeownership sectors, the restructuring of the political economy (financialization) around housing wealth and the inter-cohort dynamics surrounding the accumulation and transfer of housing wealth. The paper takes an international perspective drawing on evidence from two parallel, but contrasting cases: Japan and the UK. The analysis illustrates the interrelatedness of interand intra-generational inequalities, with the former reinforcing the latter. It also focuses on the role of families as both a moderator of generational inequity at the micro level as well as an enhancer of socioeconomic inequalities overall.
The residualisation of social housing sectors requires housing managers to intensify social management activities aimed at promoting tenants’ wellbeing and social cohesion. This paper discusses the implementation of such activities in the Italian public housing sector. It juxtaposes the vision conceptualised at the policy level with the daily activities of housing managers in practice on the ground and highlights the gaps between policy goals and realities of tenants’ involvement. While social management activities are expected to contribute to breaking the vicious circle of financial, technical, and social decline that has long affected public housing estates, the short timeframe of the planned interventions raises the question of the potential for structural change.
This article explores the trajectory of so-called guaranteed social housing in the Czech Republic as an example of penetrating financial instruments into the public policy realm. The project, promoted by the government’s Agency for Social Inclusion, was intended to encourage private landlords to rent their properties to people in need through commercial insurance against the risk of rent defaults. Using policy documents, media and interviews with governmental officers, the article describes the performative strength of financial instruments in the sphere traditionally occupied by the welfare state. In financialisation literature, the proliferation of financial instruments is often described as a one-way process in which these instruments colonise public domains. However, the empirical case discussed in the article shows that this process is much more complex and contingent, and financial instruments are not used as the best option but rather as a last resort in a situation marked by weak policies.
The question of the reasons for the extreme variation in morbidity among the gene carriers of acute porphyria and the great diversity of the precipitating factors are approached by the aid of a model of interacting genomic circuits. It is based on the current paradigm of the acute porphyric attack as a result of a toxic proximal overload of the enzyme-
deficient heme-biosynthetic patway. Porphyrogenic influx of precursors is seen as a consequence of uncontrolled induction of its gate-keeping enzyme, ubiquitous 5-aminolevulinate synthase (ALAS1), due to attenuated post-translational control of the enzyme combined with activated gene transcription. Focus is directed on the genomic
control of the master-regulator of ALAS1-transcription, the nuclear receptor pair constitutively active receptor (CAR) and pregnane xenobiotic receptor (PXR). On activation by their ligands, i.e. lipophilic drugs, solvents, alcohols, hormonal steroids and biocides, these DNA-binding proteins transform xenobiotic or steroid stimuli to coordinated
activations of gene transcription-programs for ALAS1 and apo-cytochromes P450 (apo-CYPs), thus effecting the formation of xenobiotic-metabolizing cytochrome P450 enzymes. The potency of the CAR/PXR-transduction axis is enhanced by co-activators generated in
at least four other genomic circuits, each triggered by different external and internal stimuli clinically experienced to be porphyroge
nic, and each controlled by co-activating and co-repressing modulators. The expressions of the genes for CAR and PXR are thus augmented by binding glucocorticoid receptor (GR) activated by a steroid hormone, e.g, cortisol generated in fasting, infection or different forms of stress. The promotor regions of ALAS1 and apoCYPs contain binding sites for at least three co-activating transcription factors enhancing CAR/PXR transduction: i.e. the ligand-independent growth hormone (GH)-pulse controlled hepatocyte nuclear factor 4 (HNF4), the insulin-responsive forkhead box class O-(FOXO) protein pathway activated in stress and infection, and the proliferator-activated receptor gamma co-activator 1 al
pha (PGC-1alpha) circuit responding to glucagon liberated in fasting. Many interactions and cross-talk take place within the tangle of genomic circuits that control ALAS1-transcription, which may explain the extreme inter- and intra-individual variability in morbidity in acute porphyria. Reasons for gender-differences are found in sex-dependent control of HPA- and GH-activity as well as in direct, or GR-mediated effects on CAR/PCR activation. Constitutional differences in individual porphyric morbidity may be discussed along lines of mutations or duplications of genes for co-activating or co-repressing nuclear proteins active at different levels within the circuits.
In the course of cytogenetic studies on Alegoria castelnaui Fleutiaux & Sallé 1889 (Coleoptera: Tenebrionidae: Tenebrioninae: Ulomini) from Guadeloupe, a number of adult specimens were dissected. A larva was found in the abdomens of almost all of the females. The karyotype, 20,XX / 20,Xyp, and the presence of heterochromatin at multiple chromosomal locations, of the larvae and adults were similar, which excludes parasitism and indicates viviparous reproduction. The adverse habitat of the adults, i.e., putrid and fermenting pseudo-stems of banana trees rather than geo-climatic conditions, may explain the occurrence of viviparity in this species. This is the first example of (ovo-)viviparity in the Ulomini tribe and among New World Tenebrionidae. A. castelnaui is regularly collected on banana trees infested with the weevil Cosmopolites sordidus Germar, 1824, a major pest of banana trees around the word. The coexistence of these two species on banana trees may be coincidental but another Ulomini species, Eutochia pulla Erichson 1843, is described as an egg predator of C. sordidus in Africa and therefore, A. castelnaui could also be a predator of this pest.
(Pro)renin receptor (PRR) contributes to regulating many physiological and pathological processes; however, the role of PRR-mediated signaling pathways in myocardial ischemia/reperfusion injury (IRI) remains unclear. In this study, we used an in vitro model of hypoxia/reoxygenation (H/R) to mimic IRI and carried out PRR knockdown by siRNA and PRR overexpression using cDNA in H9c2 cells. Cell proliferation activity was examined by MTT and Cell Counting Kit-8 (CCK-8) assays. Apoptosis-related factors, autophagy markers and β-catenin pathway activity were assessed by real-time PCR and western blotting. After 24 h of hypoxia followed by 2 h of reoxygenation, the expression levels of PRR, LC3B-I/II, Beclin1, cleaved caspase-3, cleaved caspase-9 and Bax were upregulated, suggesting that apoptosis and autophagy were increased in H9c2 cells. Contrary to the effects of PRR downregulation, the overexpression of PRR inhibited proliferation, induced apoptosis, increased the expression of pro-apoptotic factors and autophagy markers, and promoted activation of the β-catenin pathway. Furthermore, all these effects were reversed by treatment with the β-catenin antagonist DKK-1. Thus, we concluded that PRR activation can trigger H/R-induced apoptosis and autophagy in H9c2 cells through the β-catenin signaling pathway, which may provide new therapeutic targets for the prevention and treatment of myocardial IRI.