Autoimmune thyroiditis (AIT) and type 2 diabetes mellitus (DM2) are the most common endocrinological diseases worldwide. Relation between these diseases explains several hypotheses. One of them is influence of some adipocytokines. This study evaluated association between three adipocytokines (adiponectin, resistin and visfatin) and thyroid and glycid status in patients with DM2 and AIT compared to the control group (CG). The group consisted of four subgroups: patients with DM2 without thyreopathies, patients with AIT on substitution therapy without diabetes and prediabetes, patients with DM2 and AIT on substitution therapy and healthy subjects as the CG. We investigated parameters of thyroid and glucose metabolism and serum levels of three adipocytokines. The mean level of resistin in the group of patients with diabetes and thyroiditis was significantly higher than in patients with thyroiditis without diabetes and than in the CG. We found a weak negative correlation between visfatin and fasting glucose levels in patients with thyroiditis without diabetes. We detected a weak negative correlation between resistin and glycated hemoglobin and a weak negative correlation between visfatin and thyroid gland volume in patients with diabetes without thyroiditis. In the CG we determined a weak positive correlation between visfatin and free thyroxin. Our results are consistent with several studies, which confirmed association between AIT and adipocytokines.
We examined whether dispersal was associated with body and wing morphology and individual quality, and whether such an association was sex-specific, in the Glanville fritillary butterfly Melitaea cinxia (L.) in Paldiski on the north coast of Estonia. Body weight, size and shape of both fore- and hindwing, wing aspect ratio and wing loading were used as measures of body and wing morphology. Fluctuating asymmetry (FA) of wing shape was used as a measure of individual quality. Males and females did not differ in dispersal rates, despite large differences in overall morphology and FA. Females had a significantly higher wing loading and aspect ratio, but a lower FA than males. Females, but not males, that dispersed differed in forewing shape from those that did not disperse. The sex-specifity of the covariation between dispersal and forewing shape is most probably due to wing shape being associated with different life-history traits in both sexes, resulting in different selection pressures on wing shape in each of the sexes.
The aim was to investigate: changes of inflammatory, stress and
cardiac response in patients undergoing open heart surgeries up
to five days after the procedure; the association between
inflammatory, stress and cardiac response and whether changes
in a certain marker can predict short-term patient outcome.
Ninety patients were divided into three groups, 30 participants
each (on-pump, off-pump revascularization and valve
replacement group). The following markers were measured:
complete blood count, CRP, IL-6, IL-10, leptin, resistin, monocyte
chemoattractant protein-1 (MCP-1), cortisol, CK and hsTnT in
5 points. Resistin increased in all three groups. Lower IL-10 levels
were found after the surgery and higher levels of leptin and MCP1 in the off-pump than in the on-pump group. Off-pump group
had higher values of IL-6, IL-10, leptin, resistin and MCP-1 and
lower levels of CK and hsTnT 24 after surgery than the on-pump
group. We found significant correlation between MCP-1 and
resistin. The difference between resistin at time points 2 and 3
significantly predicted transfusion needs; while the difference
between CRP and resistin before and at the end of the surgery
together with the difference between leukocytes at the end and
24 hours after the surgery predicted the use of inotropic
agents/vasopressors. Cardiac surgeries cause an increase of
inflammatory, stress and cardiac markers. Only resistin correlated
with MCP-1 which confirms the link between resistin secreted
form infiltrated macrophages and enhanced release of MCP-1.
We investigated the association between metamphetamine dependence and TaqI A polymorphism of the dopamine receptor D2 gene (DRD2), I/D polymorphism in angiotensin-converting enzyme (ACE) and M235T polymorphism of the angiotensinogen gene (AGT) in 93 unrelated metamphetamine-dependent subjects and 131 controls. Our results did not prove any association of TaqI A polymorphism of the DRD2 gene, I/D polymorphism of ACE gene, and M235T polymorphism of AGT gene with the metamphetamine dependence in Caucasians of Czech origin. However, a significant difference in allele I frequency between male and female control groups for the I/D ACE polymorphism (p<0.03) was found., O. Šerý, V. Vojtová, P. Zvolský., and Obsahuje bibliografii
HIPPARCOS satellite should be launched in 1989. It will measure positions, proper motions, and parallaxes of about 110 000 selected stars brighter than 13, with a precision of 2 milliseconds of arc. Accurate positions (up to 1.5 arc second at the date of observation) and magnitudes (up to O. Smag) have to be known in advance. The star selection has to be optimized with respect to both scientific priorities defined by the ESA Selection Committee, and to technical constraints for satellite operation. The Input Catalogue under construction contains stars selected among the 700 000 ones proposed in 1902 ty the worldwide astronomical community. The Input Catalogue consortium is in charge of making the identifications, providing the necessary data with the required accuracy, and making the selection. A first provisional version has been established in February 1987 and its content is described :
- "survey" of bright stars, about complete up to a limiting magnitude function of both galactic latitude and spectral type, about 55000 stars.
- Painter stars from proposed programmes : nearby stars ; stars with high proper motion ; variable stars, in particular Cepheids and RR Lyrae for distance scale calibration ; open cluster stars ; stars for galactic structure studies > stars in the Magellanic Clouds / stars for reference frame ; stars for linking to the extragalactic system ; minor planets.
A rough estimate of the star distribution versus spectral types and distance is presented. The fulfilment of important astrometric or astrophysical programmes is evaluated.
We set up axioms characterizing logical connective implication in a logic derived by an ortholattice. It is a natural generalization of an orthoimplication algebra given by J. C. Abbott for a logic derived by an orthomodular lattice.
Bradykinin can enhance skeletal muscle glucose uptake (GU), and exercise increases both br adykinin production and muscle insulin sensitivity, but bradykinin’s relationship with post-exercise insulin action is uncertain. Our primary aim was to determine if the B2 receptor of bradykinin (B2R) is essential for the post- exercise increase in GU by insulin-stimulated mouse soleus muscles. Wildtype (WT) and B2 R knockout (B2RKO) mice were sedentary or performed 60 minutes of treadmill exercise. Isolated soleus muscles were incubated with [ 3 H]-2-deoxyglucose ±insulin (60 or 100 μ U/ml). GU tended to be greater for WT vs. B2RKO soleus with 60 μ U/ml insulin (P=0.166) and was significantly greater for muscles with 100 μ U/ml insulin (P<0.05). Both genotypes had significant exercise-induced reductions (P<0.05) in glycemia and insulinemia, and the decrements for glucose (~14 %) and insulin (~55 %) were similar between genotypes. GU tended to be greater for exercised vs. sedentary soleus with 60 μ U/ml insulin (P=0.063) and wa s significantly greater for muscles with 100 μ U/ml insulin (P<0.05). There were no significant interactions between genotype and exercise for blood glucose, plasma insulin or GU. These results indicate that the B2R is not essential for the exerci se-induced decrements in blood glucose or plasma insulin or for the post-exercise increase in GU by insulin-stimulated mouse soleus muscle., G. G. Schweitzer ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
In this study, the 2n = 58 chromosomal race of blind mole rats,
Nannospalax xanthodon, from the Erzincan province in Turkey was investigated. Conventional chromosome staining, Ag-NOR staining and C-banding analysis were carried out in the specimens studied. The karyotype included three small or medium-sized meta/submetacentric pairs and twenty-five acrocentric pairs of autosomes of gradually diminishing size (NFa = 62). C-heterochromatin regions were found in centromeric and pericentromeric areas or in short arms of some bi-armed autosomal pairs and in pericentromeric areas of a few acrocentric autosomes. The X chromosome had a centromeric C-positive band and the short arm of the Y chromosome appeared to be C-positively stained. The NORs were
localized in distal heterochromatin areas of the short arms of two pairs of biarmed and one pair of acrocentric autosomes. Within the 58 chromosome populations reported from Turkey, two groups can be recognized differing by the presence or absence of a large submetacentric autosomal pair. The populations possessing this marker chromosome occur in central and northern Anatolia, whereas populations form eastern Anatolia have no similar chromosome in their karyotype.