The importance of the institution of family in housing practices has deep historical roots in Greece, and families tend to follow certain housing strategies such as late emancipation from the parental home, intergenerational house transfers and financial support for housing. Providing and maintaining a housing solution for young members is one of the top worries in this geographical region, and it is relieved via intergenerational micro-solidarities. Moreover, today’s crisis and austerity are threatening, through indirect budgetary cuts and rising taxation, the housing well-being of the citizenry which is supported only by family welfare. Nonetheless, the family still constitutes the main shock absorber of social and economic turbulence, but at what price?
a1_We investigated the potential neuroprotective effect of transient hypertension on neuronal cell death induced by ischemia-reperfusion. Recovery of neurons, terminally differentiated cells, is almost entirely dependent upon active transcription and repair of DNA damage. We focused on the histochemical detection of distribution of NOR (argyrophylic nucleolar proteins) reflecting nucleolar integrity, immunohistochemical detection of PARP-1 (poly(ADP-ribose) polymerase-1), MADD (mitogen-activated death domain), a protein accumulated in nucleoli upon stimulation by ischemia, the active form of caspase-3, a universal proteolytic enzyme of apoptosis. The terminal deoxynucleotidyl-transferase (TdT)-mediated dUTP-biotin nick-end-labeling method (TUNEL) proved the presence of in situ DNA fragmentation. We used the model of transient focal cerebral ischemia in rats with occlusion of middle cerebral artery. In experimental group of rats, the transient hypertension was induced by constriction of the abdominal aorta. The period of ischemia lasted 15, 30, 60 and 120 min followed by 48 h of reperfusion. We examined the frontal lobe of the ipsilateral hemisphere for apoptosis of neurons and compared it with the intact brain tissue. In normotensive rats with transient focal cerebral ischemia, we found disintegrated nucleoli of cortical as well as subcortical neurons at all investigated periods of ischemia, whereas the neurons of intact animals showed compact nucleoli with a few satellites. Nuclear positivity for MADD and PARP-1 was apparent in the neocortex after 15 min and peaked after 30 min of ischemia. On the other hand, the subcortical neurons showed nuclear positivity after 60 and 120 min. The immunohistochemical reaction for active caspase 3 was apparent after 30 min onwards predominantly in the cortex. The TUNEL staining was distinct after 60 and 120 min., a2_In hypertensive rats, we found nucleolar disintegration, positivity for MADD, PARP-1 and caspase 3 after 30 min cortically and subcortically, followed by TUNEL positive staining of cortical neurons after 60 and 120 min. In summary, we detected delayed activation of neuronal apoptosis in transiently hypertensive rats with focal cerebral ischemia compared to normotensive animals. The apoptotic phenotype was confirmed by a panel of complementary methods showing rapid proteolysis-nucleolar segregation, MADD, PARP-1 and caspase-3 positivity as well as ultimate DNA fragmentation proved by the TUNEL assay., M. Smrčka, M. Horký, F. Otevřel, Š. Kuchtíčková, V. Kotala, J. Mužík., and Obsahuje bibliografii
Current philosophical debates about perception have largely ignored questions concerning the ontological structure of perceptual experience, so as to focus on its intentional and phenomenological character. To illustrate and put pressure on this tendency, I revisit the controversy between doxastic views of perception and Gareth Evans’s objection from over-intellectualization. I suggest that classic versions of the doxastic view are to a good extent driven by an ontological characterization of perceptual attitudes as nonfactive states or dispositions, not by a cognitively complex picture of perceptual content. Conceived along these lines, the doxastic view unveils an ontologically significant story of perceptual experience for at least two reasons: on the one hand, that characterization avoids the line of reasoning leading up to sense-datum theories of perception; and, on the other, it bears on recent discussions about the temporal structure of perceptual experience. Although I do not endorse the doxastic view, my goal is to highlight the importance of the relatively neglected ontological motivations thus driving that kind of account.
Th e emergence of the New Materialisms from a critique of the cultural or linguistic turn in social theory and its inability to adequately deal with questions of matter seems to be quite similar to the starting point of historical Materialism. But, in its reformulation of such crucial concepts and relations as subject-object- or nature-culture divisions (or, in that case, non-divisions), as well as its emphasis on the concept of contingent assemblages as an ontology of the emergence of matter and things, it is no longer human praxis which is being highlighted but the event (Ereignis) of materialization of non-human/human assemblages. Th us, it is only the contingency of matter which is leading to changes. Hence, the ontology of New Materialisms is deeply problematic. Th erefore, the paper aims to provide a critique of the main concepts of the New Materialisms by means of Marxian approaches. Th e theses are, fi rst, that the New Materialisms de-socialize things through de-socializing categories and concepts; second, that they can be assumed to represent more of an “ontological turn” than a “material turn,” which has serious epistemological consequences; and, third, they are mirroring in their negation of the subject the methodological individualism of neoliberal theory because both approaches defi ne a non-society of super-individual processes, a kind of spontaneous order which cannot be controlled by humans. In order to substantiate these assumptions the paper fi rst traces back the main categories of New Materialisms, then takes a deeper look at the subject-object- and the nature-culture relation before relating it to neoliberal society. Finally, the ontology of open-endedness and contingency will be criticized as an ontological apologia of what is.
The aim of our work was to study the opposite polarity of the PQ segment to the P wave body surface potential maps in different groups of patients. We constructed isointegral maps (IIM) in 26 healthy controls (C), 16 hypertensives (HT), 26 patients with arterial hypertension and left ventricular hypertrophy (LVH) and 15 patients with myocardial infarction (MI). We analyzed values and positions of map extrema and compared the polarity of maps using the correlation coefficien t. The IIM P maxima appeared mainly over the precordium, the minima mainly in the right subclavicular area. The highest ma xima were in the MI group, being significantly higher than in the HT and LVH groups. No differences concerning any values of other extrema were significant. The IIM PQ maxima were distributed over the upper half of the chest; the minima mainly over the middle sternum. A statistically significant opposite polarity between the IIM P and IIM PQ was found in 80 % of cases. The opposite polarity of the P wave and the PQ segment was proved in isointegral body surface maps. The extrema occurr ed in areas not examined by the standard chest leads. This has to be considered for diagnostic purposes., K. Kozlíková ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
We establish necessary and sufficient conditions under which the linear span of positive AM-compact operators (in the sense of Fremlin) from a Banach lattice $E$ into a Banach lattice $F$ is an order $\sigma $-complete vector lattice.
By a commutative term we mean an element of the free commutative groupoid $F$ of infinite rank. For two commutative terms $a$, $b$ write $a\le b$ if $b$ contains a subterm that is a substitution instance of $a$. With respect to this relation, $F$ is a quasiordered set which becomes an ordered set after the appropriate factorization. We study definability in this ordered set. Among other things, we prove that every commutative term (or its block in the factor) is a definable element. Consequently, the ordered set has no automorphisms except the identity.
Theories of the origin of the Oort ctoud are examined in the light of recent observations of comets and of star-forming environments, and some popular hypotheses are found to meet with difficulties. In particular chemical and experimental evidence that comets grow in an extremely cold, quiescent environment is proving difficult to reconcile with recent CO and IR observations showing that the environment of a star-forming region is characterised by turbulent,
high-velocity flows and that young stars are prone to recurrent, violent outbursts. The aggregation around young stars of
planetesimals pre-existing in molecular ciouds avoids these problems. However formed, the Oort cloud is disturbed through
interactions with its galactic environment. A record of these past disturbances, episodic or regular, is in principle recoverable through impact cratering and other geological signatures, and these terrestrial records therefore provide a further new constraint on the structure and evolution of the Oort cloud. The concepts of
r 'dense inner cloud' or a 'solar companion star' are difficult to reconcile with the impact cratering history. The debris from the very largest comets are expected to play a dominant role in producing galactic modulations of such fundamental phenomena as the rise and fali of oceans, ice ages, geomagnetic reversals and the origin of life. A ~15 Myr galactic cycle in particular is predicted. Power spectrum analyses applied to cratering, vulcanism and geomagnetic reversal records for the last -200 Myr reveal the presence of a 16 ± 2 Myr cycle.
Nearly 60 years has elapsed since the first isolation and identification of 7α-hydroxy-dehydroepiandrosterone, and in that time much information has been gained on its occurrence, metabolism, ontogeny, immunomodulatory activity, cell proliferation, cortisol control in local tissues and neuroactivity. Additional knowledge about this steroid may elucidate its role in obesity, neurodegenerative disturbances such as Alzheimer’s disease, or psychiatric disorders such as schizophrenia or depression. This review aims to provide a comprehensive summary of the available literature on 7α-hydroxydehydroepiandrosterone., L. Stárka., and Obsahuje bibliografii