Zpráva o konferenci, která se uskutečnila na Universitě v Birminghamu 6. - 8. ledna 2014., Miloš Zapletal., Rubrika: Konference, and Cizojazyčné resumé není.
In this paper, we study the s-Perron, sap-Perron and ap-McShane integrals. In particular, we show that the s-Perron integral is equivalent to the McShane integral and that the sap-Perron integral is equivalent to the ap-McShane integral.
Monoclonal antibody-based treatment of cancer has been established as one of the most successful therapeutic strategies for both hematologic malignancies and solid tumors. In addition to targeting cancer antigens antibodies can also modulate immunological pathways that are critical to immune surveillance. Antibody therapy directed against several negative immunologic regulators (checkpoints) is demonstrating significant success in the past few years. Immune checkpoint inhibitors, ipilimumab,
pembrolizumab and nivolumab, have shown significant clinical benefit in several malignancies and are already approved for advanced melanoma and squamous NSCLC. Based on their mechanism of action, these agents can exert toxicities that are unlike conventional cytotoxic chemotherapy, whose nature is close to autoimmune diseases -
immune related adverse events (irAEs). In this review we focus on the spectrum of irAEs associated with immune checkpoint antibodies, discussing the pharmacological treatment strategy and possible clinical impact.
We investigated the factors that impose an upper limit of salinity tolerance to the unicellular freshwater cyanobacterium Synechococcus sp. PCC 7942. Above approx. 0.4 M NaCl, Synechococcus cells cease to proliferate, after having accumulated 0.3 M sucrose. Cells that pre-accumulated sucrose could tolerate up to 0.5 M NaCl, but not 0.6 M NaCl. After exposure to 0.5 M NaCl or higher, the cells were irreversibly modified becoming unable for osmotic volume adjustments. and N. P. Ladas, G. C. Papageorgiou.
Double-regulated vertical axial water turbine with conical distributor, which is worldwide known as a Saxo-type turbine, is the main subject of this paper. Due to continuous research, development and improvement, advance and compact structure, simplified civil construction works, reliability, ecological design and versatile applicability, the turbine became very recognizable product of company Litostroj Power, with over 30 successfully commissioned units in North American and Canadian market mainly. Authors see the Saxo turbine as one of the most interesting and suitable solutions for small and medium size hydro power plants. This paper aims to draw attention on this unique and interesting turbine design especially because experiences show that hydro power plant investors are somehow conservative and they mainly prefer and trust in more conventional turbine types i.e. Kaplan turbines and tubular turbines. The paper enlightens important design, hydraulic, economic and operation advantages of the Saxo-type turbines and points out most obvious advantages comparing to tubular and Kaplan type turbines. As an evidence of safe and reliable operation, there is a special section at the end of the paper which is focused on field-feedback experiences obtained during exptensive turbine testing at commissioning tests, final field performance acceptance tests and operation experiences. and Obsahuje seznam literatury
A unifying picture to the hermeneutical approach to schizophrenia is given by combining the philosophical and the experimental/computational approaches. Computational models of associative learning and recall in the cortico-hippocampal system helps to understand the circuits of normal and pathological behavior.