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202. Level of markers of neurodegeneration in patients with ocular ischemic syndrome
- Creator:
- Kamilov, Halidjan, Kasimova, Munirahon, and Makhkamova, Dilbar
- Format:
- electronic, electronic resource, remote, and elektronický zdroj
- Type:
- model:article, article, Text, srovnávací studie, and TEXT
- Subject:
- oční nemoci--patologie, biologické markery--analýza--krev, proteiny S100--analýza--krev, fosfoenolpyruváthydratáza--analýza--krev, slzy--chemie, ischemie--diagnóza--patofyziologie, atrofie optického nervu--diagnóza--patofyziologie, staří, ženské pohlaví, lidé, mužské pohlaví, lidé středního věku, and oční ischemický syndrom
- Language:
- English
- Description:
- The purpose of this study was to investigate the content neurospecific markers protein S-100 and neuroenolaza in blood serum and tear fluid of patients with ocular ischemic syndrome. Material and methods. We observed 43 patients aged 57 to 79 years, mean age 67.3 ± 2.7 years. Control group consisted of 11 volunteers without ophthalmic symptoms. The main group consisted of 32 patients with OIS. The neurospecific proteins S100 and NSE were investigated in blood serum and tear fluid. Results. The study found that in patients of the control group the content of protein were within the normal range: S -100 in the tear fluid – 0,0662 ± 0,00335 mkg/l, in the blood serum 0,0508 ± 0,00241 mkg/l. In patients of the main group the indicators of protein in the tear fluid were elevated in all patients - 3,12 ± 0,246 mkg/l ( p<0.005). The normal evels in blood serum of marker S-100 was in 30 patients - 0,0589 ± 0,00303 mkg/l, while, in 2 patients protein S-100 were raised and averaged 0,2175±0,00725 mkg/l. It was found that in patients of the control group content of protein NSE in the tear fluid and blood serum were within normal values - 15,86 ± 0,148 Ng/ml, 15,60 ± 0,202 Ng/ml respectively. In the main group the amount of protein NSE tended to increase in the tear fluid in 23 patients and averaged 33,012 ± 3,2626 Ng/ml (p<0.005), a significant decrease the quantity of protein was observed in 9 patients, which amounted to 5,166 ± 0,8301 Ng/ml. At normal levels in the blood serum protein NSE detected in 30 patients and averaged 14,48 ± 0,263 Ng/ml, whereas, in 2 patients there was a significant increase of content of protein NSE and was 27,47 ± 3,068 Ng/ml. Conclusions. Thus, changes in the concentration of S100 and neuroenolaza in the tear fluid in patients with ocular ischemic European Medical, Health and Pharmaceutical Journal ISSN 1804-5804 syndrome allow to identify as marker of nerve cells damage of the eye, contributing to the definition in conjunction with other signs of stage and etiology of the disease., Halidjan Kamilov, Munirahon Kasimova, Dilbar Makhkamova, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
203. Lidské embryo v perspektivě bioetiky
- Creator:
- Černý, David
- Format:
- braille, electronic resource, remote, and elektronický zdroj
- Type:
- model:article, article, Text, statistics, and TEXT
- Subject:
- lidé, bioetika, člověk - počátek života--etika, metafyzika, etický relativismus, etická teorie, filosofie, bioetická témata, život, and embryo savčí
- Language:
- Czech and English
- Description:
- Článek Lidské embryo v perspektivě bioetiky se podrobně věnuje současné bioetické diskuzi o morálním statusu lidského embrya. Nejdříve si klade otázku, zda je lidské embryo od okamžiku oplození individuálním jedincem lidského druhu a kriticky hodnotí některé námitky proti individualitě lidského embrya. Poté se zaměřuje na problematiku kritérií personální identity a jejich relevanci pro bioetickou diskuzi. Kriticky se vyrovnává rovněž s tzv. konstitucionalizmem. Metafyzickou reflexi uzavírá obhajoba animalismu. V poslední části článku se hodnotí etický relativismus, utilitarismus a předkládá se nárys etické teorie Johna M. Finnise. Závěr práce tvoří teze, že lidské embryo je od okamžiku svého vzniku lidskou osobou obdařenou inherentními, nezcizitelnými lidskými právy., The article The Human Embryo from a Bioethical Perspective devotes in detail to the contemporary bioethical discussion on the moral status of the human embryo. First, it rises an issue whether a human embryo is an individual being of a human kind since the moment of fertilization and it critically assesses some objections against individuality of the human embryo. Following that it focuses on criteria of personal identity and its relevance for bioethical discussion. It critically deals with the so called constitutionalism. Metaphysical reflection is concluded by a defense of animalism. The last part of the article evaluates ethical relativism, utilitarianism and brings in an outline of an ethical theory of John M. Finnis. The conclusion of the work consists of the thesis that the human embryo is a human being since the moment of its creation, abounding in inherent, inalienable human rights., and David Černý
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
204. Liver mitochondrial enzyme system in the dynamics of experimental leukemia
- Creator:
- Kasymova, Gulmira and Zaribbaev, Ulugbek
- Format:
- braille, electronic resource, remote, and elektronický zdroj
- Type:
- model:article, article, Text, statistics, and TEXT
- Subject:
- modely nemocí na zvířatech, krysy, výzkumný projekt, leukemie--chemicky indukované, injekce subkutánní, nebezpečné látky--škodlivé účinky, játra--imunologie--účinky léků, mitochondrie jaterní--enzymologie--imunologie--účinky léků, časové faktory, and zvířata
- Language:
- English
- Description:
- In rats with leukemia activity of liver mitochondrial enzymes are decreased at 6 months. Later, we noted compensatory activation of complexes II and III of the respiratory chain and transition to decompensation stage by final deadline. The activity of complex IV of the respiratory chain remains high. These changes result from increased lipid peroxidation and decreased activity of antioxidant protection enzymes., Gulmira Kasymova, Ulugbek Zaribbaev, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
205. Locus of control - predictor of health and subjective well – being
- Creator:
- Popova, Svetlana
- Format:
- braille, electronic resource, remote, and elektronický zdroj
- Type:
- model:article, article, Text, statistics, and TEXT
- Subject:
- životní styl, volnočasové aktivity, postoj ke zdraví, interní-externí kontrola, sběr dat, zdraví, péče o sebe, dospělí, ženské pohlaví, lidé, mužské pohlaví, and mladý dospělý
- Language:
- English
- Description:
- The article presents results of a study of the relationship 'locus of control health and subjective wellbeing. In a heterogeneous sample (N = 239) in the stage of youth (1930 years) shall be established: locus of control determines 11.56% of the changes in the assessment of health, changes in health contribute to 12.82% of the variation in assessment of happiness and 6.10% in the measurement of life satisfaction. Young people with an internal locus of control are healthier, happier and more satisfied with their lives than those with an external locus of control. In a study of cause effect relationship is established that internal locus of control determines a healthier lifestyle. Inadequate health care, more severe risk factors (stress, unhealthy diet, inadequate sleep, smoking) among young people with an external locus of control, outline prospects for greater vulnerability of this group of the population of the so called "Diseases of modern society." Most preferred activities of young people beneficial to their health are: walking, relaxation, hobbies and sports, and this is the way to state "flow" (activity of happiness) and highlights the positive experiences in health., Svetlana Popova, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
206. Máme dostatek pádných důvodů pro změnu diagnostických kritérii gestačního diabetu?
- Creator:
- Šmrhová-Kovács, Tereza
- Format:
- braille, electronic resource, remote, and elektronický zdroj
- Type:
- model:article, article, Text, statistics, and TEXT
- Subject:
- lidé, ženské pohlaví, těhotenství, komplikace těhotenství, gestační diabetes--diagnóza, and směrnice pro lékařskou praxi jako téma
- Language:
- Czech
- Description:
- Tereza Šmrhová-Kovács and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
207. Máme vědět víc, nebo spíš míň? - editoral
- Creator:
- Chvála, Vladislav
- Format:
- braille, electronic resource, remote, and elektronický zdroj
- Type:
- model:article, article, Text, statistics, úvodní články, and TEXT
- Language:
- Czech
- Description:
- V. Chvála
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
208. Management bolesti v souvislosti s extrakcí hrudního drénu
- Creator:
- Pokorná, Andrea and Houzarová, Zuzana
- Format:
- 614-621, braille, electronic resource, remote, and elektronický zdroj
- Type:
- model:article, article, Text, statistics, and TEXT
- Subject:
- lidé, ošetřovatelská péče--metody--statistika a číselné údaje, metaanalýza jako téma, statistika jako téma, management bolesti--metody--statistika a číselné údaje, drenáž--metody--ošetřování--statistika a číselné údaje--škodlivé účinky, hrudní chirurgie, and bolest--etiologie--prevence a kontrola
- Language:
- Czech and English
- Description:
- Cíl: Zhodnotit doporučení pro management bolesti (nefarmakologickou intervencí) v souvislosti s extrakcí hrudního drénu v rámci ošetřovatelské péče o nemocné s hrudní drenáží. Metodika: Systematickou analýzou s využitím Evidence based nursing (klíčových slov s využitím Booleovských operátorů AND, OR i NOT) bylo v elektronických databázích, dostupných pro uživatele Masarykovy Univerzity (SCOPUS, EBSCO a MEDLINE – PubMed) vyhledáno v rámci primární analýzy 148 zdrojů. Po kritickém rozboru a s využitím vylučovacích kritérií bylo analýze podrobeno celkem 27 relevantních studií zaměřených na ošetřovatelskou péči o osoby s hrudní drenáží obecně. Podrobná druhostupňová analýza zahrnovala 7 relevantních zdrojů zaměřených na management bolesti u osob s hrudním drénem a zejména jeho extrakcí. Výsledky: Na základě kritické analýzy relevantních zdrojů nelze jednoznačně doporučit jednotnou strategii pro management bolesti, v rámci nefarmakologických intervencí, v souvislosti s extrakcí hrudního drénu. Nejčastěji je doporučován multimodální přístup analgetizace. Závěr: V dostupných relevantních zdrojích existují doporučení pro nefarmakologické ovlivnění bolesti v souvislosti s extrakcí hrudního drénu, která však nelze generalizovat s ohledem na sílu důkazu. Jedním z doposud nedostatečně ověřených postupů je užití fyzikální terapie, zejména aplikace chladu preemptivně. Dostupná doporučení nelze považovat za silné důkazy, ale navrhujeme jejich využití v klinické studii v podmínkách klinické ošetřovatelské praxe v České republice., Aim: To evaluate recommendations for pain management (by non-pharmacological intervention) in relation to the extraction of chest tube in the nursing care of patients with thoracic drainage. Methods: Through systematic analysis, using Evidence Based Nursing (keywords using Boolean operators AND, OR and NOT) the total of 148 sources were found in primary search in the electronic databases available to the users of Masaryk University (SCOPUS, EBSCO, and MEDLINE - PubMed). After a critical analysis with the use of exclusion criteria, the total of 27 relevant studies on nursing care for people with thoracic drainage in general were subjected to analysis. Detailed two-phase analysis included seven relevant sources focused on pain management in patients with chest drains, and especially its extraction. Results: On the basis of the critical analysis of relevant sources we cannot clearly recommend a unified strategy for pain management within non-pharmacological interventions in relation to the extraction of a chest tube. Using a multimodal analgesic approach is most frequently recommended. Conclusion: There are recommendations for non-pharmacological pain affecting in relation to chest tube extraction, but we cannot generalize them with regard to the strength of evidence. One of the insufficiently proven practices is the use of physical therapy, especially the pre-emptive application of cold. The available recommendations cannot be considered as strong evidence, but we suggest their use in a clinical trial in conditions of clinical practice in the Czech Republic., Andrea Pokorná, Zuzana Houzarová, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
209. Management těhotenství a způsob porodu žen s vývojovými vadami plodu
- Creator:
- Binder, Tomáš, Vlk, Radovan, and Černý, Miloš
- Format:
- braille, electronic resource, remote, and elektronický zdroj
- Type:
- model:article, article, Text, statistics, abstrakt z konference, and TEXT
- Language:
- Czech
- Description:
- Tomáš Binder, Radovan Vlk, Miloš Černý
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
210. Medical law and ethics - recenze publikace
- Creator:
- Doubek, Pavel
- Format:
- braille, electronic resource, remote, and elektronický zdroj
- Type:
- model:article, article, Text, review, recenze, and TEXT
- Subject:
- zákonodárství lékařské, lékařská etika, eutanazie--zákonodárství a právo, klonování organismů, experimenty na lidech, asistovaná reprodukce, and lidé
- Language:
- Czech and English
- Description:
- In a review of the book " Medical law and ethics " by Jonathan Herring, I made it my goal to familiarize the reader with the issues of medical law and ethics, which author discuss in his work . The book should be a valuable source of knowledge for both, experts and laymen, because the author dealt with many topics from different angles, that raise a number of legal and ethical issues (the issue of euthanasia , research on humans , cloning , sterilization , etc. .). I focus on these topics in eleven chapters of my review and I also add my comment , as well as comments of other authors and case law. and Mgr. Pavel Doubek
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public