Viral hepatitis B and C is a relevant issue because of high prevalence and degree of chronicity, late diagnosis and poor prognosis. Today, protein products of numerous genes are involved in the pathogenesis of viral pathology of the liver. In this review, the authors analysed 42 literature sources on genetic basis of susceptibility to various infectious diseases. Study of the role of immunogenetic factors is of great practical importance to develop methods for predicting outcomes of viral hepatitis., Khamid Karimov, Sevara Azimova, Bakhtiyor Iriskulov, and Literatura
We report the case of a 52year old man with severe acute pancreatitis. In this case report we discuss the undesirable effects of parenteral nutrition and the importance of nutritional support at patients with severe necrotizing pancreatitis. Severe acute pancreatitis is usually accompanied by systemic inflammatory response syndrome, which results in hypermetabolism with prominent protein catabolism. Providing nutrition to these patients is of paramount importance. An adequate nutritional support is crucial in patients with severe and complicated pancreatitis. A negative energy balance has a negative impact on the nutritional status and the disease progression., Shpata Vjollca, Kuneshka Loreta, Kurti Floreta, Ohri Ilir, and Literatura
This research paper presents the results of ovarian reserve estimation for 125 women with the Polycystic Ovary Syndrome (PCOS) who have undergone various methods of surgical treatment resection of the ovaries, thermokauterisation and drilling by laser (HoYag). Ovarian reserve was estimated according to the amount of antral follicles, level of follitropin and Müllerian inhibiting substance (MIS), also named antiMüllerian hormone (AMH). Blood flow in ovarian tissue was also examined after various methods of surgical treatment. The study has shown that the gentlest method of surgical treatment is drilling by HoYag laser, which is least likely to injure the tissue of ovaries, and also this method is most effective in enhancing and preserving ovarian reserve., Vasiliy Simrok, Daria Simrok-Starcheva, and Literatura
Práce se zabývá interferencí dobutaminu s metodami využívajícími princip Trinderovy reakce a podmínkami získání vzorku u pacientů v intenzivní péči. Dobutamin výrazně snižuje koncentrace některých analytů (kreatinin stanovený enzymově, kyselina močová, triacylglyceroly, cholesterol, lipáza). Interference se projeví pouze při hrubém porušení zásad pro odběr vzorků., The main goal of the study is to examine analytical interference caused by dobutamine influencing methods based on Trinder peroxidase reaction and possible preanalytical pitfalls in Intensive Care Units. Dobutamine interference has significant impact on some laboratory tests, causing falsely low values upon determination of: Creatinine - enzymatic method, Uric acid, Triglycerides, Cholesterol and Lipase. The phenomenon occurs predominantly as a result of violating specimen collection rules., Sečník P. Jr., Franeková J., Komínková M., Kotrbatý J., Hunal Z., Tlučhořová D., Jabor A., and Literatura 5
The benefits of implementing interprofessional and teambased programs are well recognized. However, for interprofessional education to be effective and broadly implemented, the health professions, policymakers, insurers, academic institutions, health care providers, and regulatory bodies should embrace and adopt a new, interprofessional education framework. These stakeholders should create a shared value and vision for interprofessional health professions education, research, and practice. This vision should be patientoriented and contain a measurable component across the entire educational continuum, from admission into a health professional program through retirement. Such a framework would maximize and value the strengths of individual professions in the integrated delivery of high quality care. Finally, in creating a successful model, a series of questions should be considered: how best can team competence be measured, how should individual behavioral changes be documented when we think of individual rather than teamlevel changes, how do we create and measure performance criteria based on shared understanding and experience in the practice setting? Within academic settings, there are more specific barriers including a lack of administrative support, financial and human resources for interprofessional education, conflicts in schedules and health professions curricula, and limitations to the time required to plan and implement faculty development for interprofessional learning. Finally, despite progress, there remain regulatory and professional barriers to achieving full and meaningful implementation of effective models. Recommendations which are given emphasize that investing in research to evaluate the efficacy of continuing education and its impact on patient outcomes and the healthcare delivery system is inherent in this process., Biljana Gjorgjeska, and Literatura
Tumory centrálního nervového systému (CNS) tvoří 20-25% všech nádorových onemocnění u dětí do 15 let věku, jsou hlavní příčinou úmrtí onkologických dětských pacientů (1). Asi 30% nádorů se vyskytuje do 5 let věku, 70-75 % se vyskytuje do 10 let věku. Nádory CNS jsou lokalizované převážně (60%) v zadní jámě: medulloblastom, low-grade astrocytom, ependymom. Práce je zaměřena na problematiku intraventrikulárních tumorů., Central nervous system tumors (CNS) account 20-25% of all malignancies in children under 15 years of age. They are the main cause of death in pediatrie oncology patients (1). Approximately 30% of CNS tumors occur under 5 years of age, 70-75% are found under 10 years of age. 60% are found in posterior fossa: medulloblastoma, low-grade astrocytoma, ependymoma. The article is directed to intraventricular tumors in children., Jarmila Skotáková, Marcela Charvátová, Vlastirad Mach, Jan Šenkyřík, JiříVentruba, Zdeněk Mackerle, Zdeněk Pavelka, Karel Zitterbart, and Literatura 16
Invazívne mykotické infekcie predstavujú závažnú infekčnú komplikáciu imunokompromitovaných pacientov. V porovnaní s bakteriálnymi infekciami je ich výskyt menej častý, na druhú stranu mortalita s nimi spojená je výrazne vyššia než je tomu u infekcií bakteriálnych. Posledné dve desaťročia priniesli významné zmeny v epidemiológii invazívnych mykóz a behom posledných niekoľkých rokov došlo k značným pokrokom v diagnostike a liečbe., Invasive fungal infections are serious life-threatening complication in immunocompromised patients. They are rare in comparison with bacterial infection but attributable mortality is higher. Last two decades brought significant changes in epidemiology of invasive fungal diseases and the last few years brought much progress in diagnostics and treatment., Martina Tošková, Jana Winterová, Iva Kocmanová, Zdeněk Ráčil, and Literatura