Studie Vojtěcha Kyase se analyticky zabývá originálním zpracováním částí mešního textu Gloria, konkrétně Domine Deus a Agnus Dei, v mši Es dur, D 950, hudebního skladatele Franze Schuberta, This study focuses on the question of Schubert’s handling of the Mass text in the Gloria of his Mass in E-Flat Major, D 950. Schubert adapts the text of the Mass to his compositional and conceptual intent. Contrary to usual practice during that period, he joins the section Domine Deus, Agnus Dei together with the qui tollis peccata mundi into a single unit, attempts to make it sound as dramatic as possible, and understands it as a breaking point. This extensive musical passage of 86 measures differs from the surrounding music with its own tempo, meter, and tonal center. At the conclusion of the article, the author also makes reference to the importance of so-called historical concerts held at the home of the music historian R. G. Kiesewetter, which Schubert appears to have attended already before the year 1820., Vojtěch Kyas., Rubrika: Studie, and České resumé na s. 138, anglický abstrakt 131.
a1_Young intact (18 days of age) and adult ovariectomized (OV-X, ovariectomized between 21 to 24 days of age) C3H/Di mice were used to measure the estrogenicity on the basis of the growth response of mammary epithelial structures and weight of the uterus. The percentage area of the mammary fat pad occupied by mammary epithelial structures was progressively increased by 17ß estradiol from dose 0.001 µg.d-1. The maximum effective dose of estradiol was 0.01 µg.d-1 and the dose 10 µg.d-1 of estradiol decreased mammary size to control levels (inverted-U-shaped dose-response curve). Progesterone alone progressively stimulated mammary growth in young intact females from dose 125 µg.d-1, in adult OV-X animals from dose 1000 µg.d-1. Both in young intact and adult OV-X animals, uterine weight progressively increased during estradiol treatment. Progesterone alone had no effect on uterine weight in young intact animals; in adult OV-X animals, uterine weight was increased starting from dose 250 µg.d-1. Progesterone acted synergistically with estradiol to produce higher mammary growth than that in females treated with estradiol alone. The effects of a combination of estradiol plus progesterone in the mammary gland were mimicked by norethindrone acetate and inhibited by cortisol in both young intact and adult OV-X animals. Testosterone inhibited estradiol plus progesterone stimulated growth of mammary gland only in OV-X animals, but stimulated uterine weights in both young intact and adult OV-X animals. Spleen weight and size of mammary lymph nodes were not affected by estradiol, progesterone, norethindrone acetate or testosterone, but were decreased by cortisol. Cortisol also decreased the percent area of the mammary fat pad occupied by mammary epithelial structures, but had no effect on weight of the uterus. These results show that bioassay of estrogenicity in females is not specific., a2_Mammary and uterine growth is stimulated not only by estrogens but also by progesterone and testosterone, respectively. ., J. Škarda., and Obsahuje bibliografii
a1_Young intact (18 days old) and adult castrated males of CBA and C3H/Di mice were used for measuring the estrogenicity on the basis of growth response of mammary epithelial structures and the weight of seminal vesicles. It was demonstrated that heavier young males had disproportionally heavier seminal vesicles (sex steroid-responsive organs) than small animals at day 33 of age (that is on the day when experimental animals were killed and organs dissected). However, the weight of the spleen (sex steroid-nonresponsive organ) was proportionally related to body weight. To minimize variability in hormone responsiveness, all animals were weighed at the age of 18 days and only males weighing 8±1 g were used for hormone treatment. The percentage area of mammary fat pad occupied by mammary epithelial structures was progressively increased by 17ß estradiol from dose 0.01 µg.d-1. The maximum effective dose of estradiol was 0.1 µg.d-1 and dose 10 µg.d-1 of estradiol decreased mammary size to control level (inverted-U-shaped dose-response curve). Progesterone alone stimulated mammary growth only in high doses (500 µg.d-1 and higher) in young intact males, but had no effect on mammary growth in adult castrated animals. In young intact males, estradiol alone, or progesterone alone decreased the weight of seminal vesicles. No such inhibitory effect of these hormones was noted in adult castrated males. Progesterone acted synergistically with estradiol to produce higher mammary growth compared to that in males treated with estradiol alone. In the presence of progesterone seminal vesicles weight was decreased by estradiol given in such low doses as 0.001 µg.d-1 of estradiol, which is 10 times lower than that effective in animals treated with estradiol alone. On the other hand, in the adult castrated males a combination of estradiol plus progesterone stimulated seminal vesicles weight., a2_The effects of a combination of estradiol plus progesterone in the mammary gland were mimicked by norethindrone acetate (a synthetic steroid exhibiting progestantial and estrogenic activities) and inhibited by both testosterone and cortisol. Estradiol, progesterone, norethindrone acetate, or testosterone did not affect spleen weight and size of mammary lymph nodes. However, cortisol significantly decreased not only spleen weights but also size of mammary lymph nodes. These results show that simultaneous evaluation of mammary gland growth, seminal vesicles, and the spleen weight in the same animal is suitable for bioassay of estrogenicity as well as for detection of androgenic and antiandrogenic activities., J. Škarda., and Obsahuje bibliografii
a1_The decreased oxidizability of plasma lipoproteins is related to the increased vitamin E intake and its association with a relatively lower incidence of coronary heart disease has been proposed. We investigated the effect of the in vivo vitamin E supplementation on the oxidizability of serum lipids in patients with ischemic heart disease and a moderate hypercholesterolemia. Thirty-two patients (16 males and 16 postmenopausal women) participated in this placebo-controlled, randomized trial. They were treated with 400 mg vitamin E/day for 6 weeks. The copper-induced serum lipid oxidizability ex vivo was assessed by measuring conjugated diene formation at 245 nm. We also measured vitamin E, malondialdehyde (MDA) and uric acid concentrations in the plasma. Because of observed significant differences in parameters of serum lipid oxidizability (lag time and maximal rate of oxidation), plasma a-tocopherol and MDA levels between male patients and postmenopausal women supplemented with vitamin E, the results were compared between both genders. Six weeks of vitamin E supplementation significantly increased plasma vitamin E levels (by 87 %) in male patients but in postmenopausal women only by 34 %. Concomitantly with increased plasma levels of vitamin E the decrease in plasma MDA levels was observed in male patients (decrease by 20 %; p=0.008), but in postmenopausal women the decrease did not attain statistical significance. Plasma uric acid levels were not apparently changed in placebo or vitamin E supplemented groups of patients. The changes in ex vivo serum lipid oxidizability after vitamin E, supplementation have shown a significantly prolonged lag time (by 11 %; p=0.048) and lowered rate of lipid oxidation (by 21 %; p=0.004) in male patients in comparison with postmenopausal women., a2_Linear regression analysis revealed a significant correlation between plasma vitamin E levels and the lag time (r=0.77; p=0.03) and the maximal rate of serum lipid oxidation (r=-0.70; p=0.05) in male patients. However, in postmenopausal women the correlations were not significant. We conclude that 400 mg vitamin E/day supplementation in patients with ischemic heart disease and a moderate hypercholesterolemia influenced favorably ex vivo serum lipid oxidation of male patients when compared with postmenopausal women. The observed differences between both genders could be useful in the selection of the effective vitamin E doses in the prevention of coronary heart disease., A. Nagyová, V. Mongiellová, Z. Krivošíková, P. Blažíček, V. Spustová, M. Gajdoš, R. Dzúrik., and Obsahuje bibliografii
It was previously shown that 4 hours´ lasting inhibition of nitric oxide synthesis by administration of an L-arginine analogue, the NG-nitro-L-arginine methyl ester (L-NAME) changed the affinity of the Na-binding site of Na,K-ATPase thus resulting in elevation of enzyme activity especially at higher concentrations of sodium. Using the same experimental model, we focused our attention in the present study to the question of binding of ATP to the enzyme molecule in the left ventricle (LV), ventricular septum (S) and the right ventricle (RV) of the dog heart. Activation of the enzyme by increasing concentrations of ATP revealed a significant increase of the Vmax only in septum (by 38 %). The KM increased significantly in septum (by 40 %) and in left ventricle (by 56 %) indicating an altered sensitivity of the ATP-binding site of Na,K-ATPase in the hearts of NO-deficient animals. The alterations of Na,K-ATPase in its ability to bind and hydrolyze ATP are localized to the tissue surrounding the cavity of the left ventricle., N. Vrbjar, M. Strnisková, O. Pecháňová, M. Gerová., and Obsahuje bibliografii
Studie se zaměřuje na definici a operacionalizaci konceptu školní šikany za účelem měření jejího výskytu ve školních kolektivech. Autoři poukazují na nejednotnost operacionalizace kritérií šikany, která je jedním z hlavních faktorů výrazně omezujících porovnání zachycené prevalence. Předkládají rozbor jednotlivých kritérií šikany a aplikují je na formy, jimž byla dosud věnovaná nedostatečná pozornost, jako jsou vztahová či psychická šikana a sociální exkluze. V návaznosti na to předkládají metodologická doporučení pro vyšetření školní šikany a pro zveřejňování nálezů., The paper focuses on the definition and operationalization of the concept of school bullying for the purpose of the prevalence measurement in school groups. It draws attention to the current disagreement concerning the defining criteria of bullying, which is one of the important factors that considerably limit the analyses of bullying prevalence. The authors examine the defining criteria of school bullying and apply them to the forms of bullying that have so far been under-researched, such as relational/psychological bullying and social exclusion. As a conclusion, specific methodological recommendations for the prevalence measurement of school bullying and the publication of research findings are presented., Pavlína Janošová, Lenka Kollerová, Kateřina Zábrodská., and Obsahuje seznam literatury
Studie si klade za cíl analyzovat vztahy mezi sociálně-psychologickými faktory a stavem zdraví se zaměřením zejména na onemocnění rakovinou prsu. Soustřeďuje se na mapování vztahu sociálně-psychologických faktorů a fyzického a psychického zdraví jedince. Shrnuje významné zahraniční a české výzkumy od počátku 90. let do současnosti. Ojediněle jsou citovány významné zahraniční studie z 80. let. V mnoha studiích zjištěný pozitivní účinek sociální opory na zdraví je obvykle vysvětlován „nárazníkovým“ modelem nebo modelem přímého účinku. Dále jsou podrobněji analyzovány výzkumy zabývající se vlivem sociální opory u žen s rakovinou prsu. V případě rakoviny prsu dosavadní studie poměrně systematicky dokumentují pozitivní vztah mezi sociální oporou a průběhem nemoci či pravděpodobností přežití. Včasná psychosociální léčba může snížit pravděpodobnost recidivy onemocnění. V českém prostředí nejsou dosud nicméně zkoumaná témata propracovaná tak, jak je tomu v západoevropském či anglosaském světě, také zde neexistuje ucelená koncepce věnující se komplexnímu výzkumu zdraví a nemoci a sociálních faktorů., The study aims to analyze the relationship between socio-psychological factors and state of health, with a particular focus on breast cancer. The first part of the study focuses on mapping the relationship of socio-psychological factors and physical and mental health of an individual. The study summarizes the major foreign and Czech studies since the early nineties to the present. The positive effect of social support, which was observed in many studies, is usually explained by a “buffer model” or by “models of direct effect”. In the second part of the study, surveys on the impact of social support among women with breast cancer are analyzed. Previous studies document the positive relationship between social support and breast cancer progression or survival probabilities. Early psychosocial treatment can reduce the likelihood of illness recurrence. However, in the Czech Republic the research topics are not yet explored and elaborated sufficiently, as in the case of Western Europe or English-speaking world. There is also no existing coherent concept dealing with the comprehensive, Kristina Březinová, Dana Hamplová, Jitka Buriánková., and Obsahuje seznam literatury
a1_strukturu a míru vnímané sociální opory u dětí a dospívajících po léčbě onkologického onemocnění a porovnat ji s oporou kontrolní skupiny. Soubor a metoda. Ve studii byla použita data od 101 dětí a dospívajících po léčbě onkologického onemocnění a data od 231 jedinců z běžné populace. Všem respondentům byl předložen Dotazník sociální opory QOLOP, který byl sestaven pro účely projektu QOLOP (Quality of Life Longitudinal Study in Oncology Paediatric Patients). Hypotézy. Vnímaná sociální opora od rodičů je u dětí a dospívajících po léčbě onkologického onemocnění vyšší než u jedinců z běžné populace. Sociální opora poskytovaná kamarády je nižší u dětí a dospívajících po léčbě onkologického onemocnění v porovnání s jedinci z běžné populace. Výzkumné studie / 339 Statistická analýza. Analýza dat (deskriptivní statistika a faktoriální analýza rozptylu) byla provedena v programu SPSS., a2_Výsledky. Největším zdrojem vnímané sociální opory u obou skupin jsou rodiče (zejména matka). Jako další důležité zdroje opory byli uváděni prarodiče, kamarádi a sourozenci. Děti a dospívající po léčbě onkologického onemocnění pociťují větší míru opory od matky, učitelů, prarodičů, sourozenců i kamarádů, než jedinci z běžné populace. Určité rozdíly ve vnímané sociální opoře byly nalezeny také mezi věkovými skupinami a mezi pohlavími. Omezení studie. Ve studii nebyl sledován zdravotní stav kontrolní skupiny. V rámci skupiny dětí a dospívajících po léčbě onkologického onemocnění nebylo přihlíženo k věku při diagnostikování onemocnění a délce remise., b1_Objectives. The purpose of this study is to describe the structure and the level of perceived social support in childhood cancer survivors and compare it with the support of control group. Sample and settings. Data from 101 childhood cancer survivors and 231 individuals from the general population were used. To determine the structure and level of social support Questionnaire of social support QOLOP which was originally designed for the QOLOP (Quality of Life Longitudinal Study in Oncology Paediatric Patients) project was used. Hypotheses. Perceived parental social support in childhood cancer survivors is higher than in the general population. Social support provided by friends is lower in childhood cancer survivors than in the general population. Statistical analysis: The statistical analysis (descriptive statistics and factorial analysis of variance) was performed using SPSS., b2_Results. Parents (especially mothers) were the most important sources of perceived social support for both groups. Grandparents, friends and siblings were mentioned as relevant sources of social support, too. Childhood cancer survivors perceived higher level of social support from mothers, teachers, grandparents, siblings and friends. Specific differences in perceived social support were also found depending on age and gender. Study limitation. The health status of control group was not monitored. In the group of childhood cancer survivors, the age in time of diagnosis and the time since the end of the treatment were not taken into account., Veronika Koutná, Marek Blatný, Tomáš Kepák, Martin Jelínek, Tereza Blažková., and Obsahuje seznam literatury
This study reviews existing research devoted to the topic of social support in childhood cancer survivors, the structure of their social network and its influence to selected characteristics of childhood cancer patients and survivors according to the source of support. Parents, siblings, friends, medical staff, classmates and teachers are analyzed as support sources. Positive as well as negative social support outcomes are reported. Among the positive outcomes, lower levels of anxiety, loneliness and pain, quality of life improvements and strenghtening of coping strategies can be named. Negative outcomes can be represented for example by excessive paren tal care, lack of privacy and feeling of being left out after the end of treatment. The limits of existing research are discussed, too., Tereza Blažková, Veronika Koutná., and Obsahuje seznam literatury
Studie Kateřiny Nové se zabývá vzájemnými vztahy mezi dirigentem Václavem Talichem a hudebním vědcem Otakarem Šourkem, které vykládá s pomocí dochované korespondence těchto osobností., The friendship between the music writer, critic, and organizer Otakar Šourek and the world-famous conductor Václav Talich lasted nearly 50 years. We can get an idea of the intensity of their friendship by studying their mutual correspondence. Šourek always deeply admired Talich, and he tried to support him with all of his might (although not unconditionally). Talich, on the other hand, respected Šourek, and he confided in him about his everyday cares and joys, but in their correspondence we also find deep reflections about the music of Antonín Dvořák or comments about current politics and social issues. Talich’s letters thus give us a glimpse beneath the surface of the daily life of one of the most prominent Czech conductors., Kateřina Nová., Rubrika: Studie, and Anglické resumé na s. 319, anglický abstrakt 301.