The Family Library of the noblemen Nostitz and Rieneck has been housed in the Nostitz Palace in Prague since the 1770s, now administered by National Museum Library. Some of the 14,000 copies reused a parchment book binding which had been originally used in liturgical books from the 14th and 15th centuries. The article dissects sixty-six parchment book bindings with notations: the key part of the study provides a list of these book bindings with details about each book: the musical content of fragments, their notation, and dating. This list is introduced by a text on the history of the Nostitz Library, paying special attention to the incorporated Castle library of Otto Jr. of Nostitz (1608–1665), originally from Jawor in Lower Silesia. Since the vast majority of the notated bindings were detected on books signed by Otto Jr. of Nostitz, the musical-palaeographical analysis of the fragments also examines possible influences of the Polish notation tradition.