After 1918, the newly created Czechoslovakian Republic offered a helping hand to many thousands of Ukrainians who had fled their native country, which had been occupied by the Soviet Union. The young Ukrainian intelligentsia studied at Czech secondary schools and universities, in Prague at the Mikhail Drahomanov Pedagogical Institute (1923–1933), and in Řevnice, near Prague, at a Ukrainian Secondary School. Several dozens of Ukrainian students studied, supported by the Czechoslovakian state, at Prague Conservatoire. Special attention is paid here to the students of composition (including Mykola Kolessa, Hryhory Dyachenko, Zenovy Lysko, Nestor Nyjankivsky and Roman Simovych).
The aim of the work is to analyze the peculiarities of Ukrainian secondary education abroad in the 1920s and 1930s on the example of the Ukrainian secondary school („Ukrainian Gymnasium“) in Czechoslovakia. The analysis of features of the organization, methodological bases of educational work of the Gymnasium in Prague as a part of the general cultural and educational activity of the Ukrainian interwar emigration is carried out.
Retroviry jsou jednoduché RNA viry, které se vyznačují schopností přepsat svou RNA do dvouřetězcové DNA a tu stabilně začlenit do genetické informace hostitelské buňky. Tato jejich vlastnost stojí za latencí viru HIV, která v současnosti představuje hlavní překážku v úspěšné léčbě HIV pozitivních pacientů. Na druhou stranu lze této jejich vlastnosti využít pro přenos genetické informace za účelem léčby četných chorob s využitím přístupů genové terapie. Pro tyto účely je však potřeba retroviry vybavit sekvencemi, které zajistí jejich stabilní aktivitu a ochrání je před umlčením., Retroviruses are simple RNA viruses, which exhibit an ability to convert their RNA to double-stranded DNA and introduce it into the host cell genome. This ability stands behind the HIV latency phenomenon - a major obstacle to successful therapy. On the other hand, this capability can be utilized for the transfer of genetic information in order to cure various diseases using gene therapy approaches. To achieve successful therapy, the retroviruses need to be equipped with sequences protecting them from silencing, thus stabilizing their activity., and Filip Šenigl.
Ulinastatin [or called as urinary trypsin inhibitor (UTI)] plays a role in regulating neurological deficits evoked by transient cerebral ischemia. However, the underlying mechanisms still need to be determined. The present study was to examine the effects of UTI on autophagy, Nrf2-ARE and apoptosis signal pathway in the hippocampus in the process of neurological functions after cerebral ischemia using a rat model of cardiac arrest (CA). CA was induced by asphyxia followed by cardiopulmonary resuscitation (CPR) in rats. Western blot analysis was employed to determine the expression of representative autophagy (namely, Atg5, LC3, Beclin 1), p62 protein (a maker of autophagic flux), and Nrf2-ARE pathways. Neuronal apoptosis was assessed by determining expression levels of Caspase-3 and Caspase-9, and by examining terminal deoxynucleotide transferase-mediated dUTP nick-end labeling (TUNEL). The modified neurological severity score (mNSS) and spatial working memory performance were used to assess neurological deficiencies in CA rats. Our results show that CA amplified autophagy and apoptotic Caspase-3/Caspase-9, and downregulated Nrf2-ARE pathway in the hippocampus CA1 region. Systemic administration of UTI attenuated autophagy and apoptosis, and largely restored Nrf2-ARE signal pathway following cerebral ischemia and thereby alleviated neurological deficits with increasing survival of CA rats. Our data suggest that UTI improves the worsened protein expression of autophagy and apoptosis, and restores Nrf2-ARE signals in the hippocampus and this is linked to inhibition of neurological deficiencies in transient cerebral ischemia. UTI plays a beneficial role in modulating neurological deficits induced by transient cerebral ischemia via central autophagy, apoptosis and Nrf2-ARE mechanisms., Xiao-Ming Jiang, Jing-Hai Hu, Lu-Lu Wang, Chi Ma, Xu Wang, Xiao-Liang Liu., and Obsahuje bibliografii
The measurement process as an integral part of quality management systems. Eligibility of the measuring system and the most important normative regulations for the quality control of measuring processes. Descriptions of the most important methodologies for assessing the competence of measuring systems. and Proces měření jako nedílná součást systémů řízení kvality. Způsobilost měřicího systému a nejdůležitější normativní předpisy pro řízení kvality měřicích procesů. Popisy nejdůležitějších metodik hodnocení způsobilosti měřicích systémů.
Motivací k sepsání tohoto příspěvku a k představení teoretické úlohy ze 46. mezinárodní fyzikální olympiády "Extremální princip" (viz níže) bylo zamyslet se nad rolí a potřebností vysokoškolské matematiky v soutěžních úlohách mezinárodní fyzikální olympiády., Jan Kříž, Filip Studnička, Ľubomír Konrád, Bohumil Vybíral., and Obsahuje bibliografii