I explain how Karl Popper resolved the problem of induction but not the pragmatic problem of induction. I show that Popper's proposed solution to the pragmatic problem of induction is inconsistent with his solution to the problem of induction. I explain how Popper’s falsificationist epistemology can solve the pragmatic problem of induction in the same negative way that it solves the problem of induction.
Apolipoprotein E (apoE) is a polymorphic protein which occurs in three common isoforms and more than 25 rare variants. Some of the rare apoE variants have been implicated in a dominant mode of inheritance of familial dysbetalipoproteinemia (FD). We have identified three unrelated apoE 2*(Arg136®Cys) carriers with FD. This finding supports the notion that although apoE 2*(Arg136®Cys) mutation is perhaps not sufficient to cause FD itself, the presence of other genetic and/or environmental factors can lead to the phenotypic expression of the disease in the carriers., M. Vrablík, A. Hořínek, R. Češka, T. Štulc, T. Kvasnička., and Obsahuje bibliografii
Familial hypercholesterolemia (FH) is the most common autosomal dominant disorder. It is characterized by a de crease in LDL cholesterol catabolism and an early clinical manifestation of atherosclerotic vessel damage. The aim of the MedPed (Make early diagnosis to Prevent early deaths) project is an early diagnosis of FH patients in order to profit from early treat ment and prevent cardiov ascular events. Till November 30, 2016 The Czech National MedPed Database has registered 7,001 FH patients from 5,223 different families that is 17.4 % of expected patients in the Czech Republic considering 1:250 FH prevalence. The improvement in diagnostic accuracy, patient cooperation and above all familial cascade screening is enabled by FH mutation detection using the modern technology of next-generation sequencing. FH still remain undiagnosed even though the Czech Republic is on e of the most successful countries with respect to FH detection. The opportunities of international collaboration and experience sharing within international programs (e.g. EAS FHSC, ScreenPro FH etc.) will improve the detection of FH patients in the futur e and enable even more accessible and accurate genetic diagnostics., M. Vrablík, M. Vaclová, L. Tichý, V. Soška, V. Bláha, L. Fajkusová, R. Češka, M. Šatný, T. Freiberger., and Obsahuje bibliografii
Objective: To examine the impact of family history of diabetes mellitus 2 (DM 2) on insulin sensitivity and secretion in lean women with polycystic ovary syndrome (PCOS). Thirteen healthy women (C), 14 PCOS without family history of DM 2 (FH-) and 8 PCOS with family history of DM 2 (FH+) were examined using euglycemic hyperinsulinemic clamp and an arginine secretion test (insulin and glucagon at fasting glycemia (AIRFG and AGRFG) and at hyperglycemia (AIR14 and AG 14)). FH+ women were more insulin resistant than FH- with lower insulin sensitivity index corrected per lean body mass (p<0.05). They had significantly higher triglycerides (p<0.05) and lower HDL-cholesterol (p<0.05) than C or FH- women. Concerning insulin secretion, AIR FG was increased in FH+ women comparing FH- women (p<0.05). Disposition indices derived from AIRFG or AIR14 and insulin sensitivity index did not differ between FH+ or FH-. Thus, women with PCOS with the concomitant family history of DM 2 have lower insulin sensitivity than healthy control women. Insulin resistance observed in these women with PCOS is compensated by increased insulin secretion., J. Vrbíková, T. Grimmichová, K, Dvořáková, M. Hill, S. Stanická, K. Vondra., and Obsahuje bibliografii a bibliografické odkazy
Oeuvre 5. No. 1, (Statement of Responsibility) dediée à Mademoiselle Valérie Boissier par Fr. Liszt, and (Ownership) Klášter minoritů (Český Krumlov, Česko)
A review on far-infrared brightness-temperature maps of the solar atmosphere is presented. They have been taken with the aid of a 60 cm-diameter balloon-borne telescope at a height of 39 km in France. Three bandpass filters at the wavelengths 50 μm, 80 μm and 200 μm of 6 to 10 % bandwidth have been applied. The filters as well as the Au-doped Ge bolometer were cooled by liquid He. An
observation on 30.4.83 represents the active sun, while one on 28.9.84 shows the quiet sun. The observations at the three wavelengths correspond to three different heights in the solar atmosphere at the transition of the photosphere and chromosphere. Over active regions, average temperature enhancements of 75 K to 250 K are observed relative to the inactive regions depending of the height in the solar atmosphere.
Odbornou i laickou veřejnost nedávno vzrušila zpráva, že ve Spojených státech amerických došlo k detekci gravitačních vln v observatoři Advanced LIGO, což je soustava optických interferometrů navržená právě k tomuto účelu. Náš příspěvek seznamuje čtenáře s Advanced LIGO jako optickým přístrojem a ukazuje, jak se optické technologie, původně vyvinuté pro toto unikátní zařízení, uplatňují jinde., Academia and the general public were recently excited by the news that gravitational waves were detected in the Advanced LIGO observatory (USA). LIgo is a set of optical interferometers designed for the propose of gravitational wave detection. This contribution informs readers with regard to the Advanced LIGO as an optical device and shows how optical technologies, originally developed for this unique device, are applied in other fields of research and development., and Obsahuje seznam literatury