Galanin and galanin receptors (GalRs) have been reported to be
involved in the transmission and modulation of nociceptive
information in the central nervous system (CNS). However, the
underlying mechanism of the antinociception of GalRs in
neuropathic pain remains unclear. This study investigated the
antinociception induced by galanin receptor 1 (GalR1) via protein
kinase A (PKA) signaling pathway in the nucleus accumbens
(NAc) of rats with neuropathic pain. A mononeuropathy model
was replicated by ligation of the left sciatic nerve, following which
the expression of phospho-PKA (p-PKA) in the NAc were
markedly up-regulated at 14th and 28th day after ligation of sciatic
nerve, and p-PKA expression was down-regulated by intra-NAc
injection of GalR1 agonist M617, but the GalR1 antagonist M35
did not have an effect. We also found that M35 in the NAc
blocked the M617-induced increase in the hind paw withdrawal
latencies (HWLs) of rats with mononeuropathy, but M35 alone
had no effect on HWLs, and PKA inhibitor H-89 attenuated the
M617-induced an increase in the HWLs. These results suggested
that GalR1 induced an antinociception via inhibiting PKA
activation, implying that GalR agonists may be potential and
potent therapeutic options to treat chronic neuropathic pain.
The book entitled "Assayer" published in 1623 was a controversial text about the theory of comets between Galileo and his opponent Horatio Grassi, the Jesuit mathematician. Galileo was an author of the original but false optical theory of comets while Grassi proposed a supra-lunar origin of comets supporting Tycho's opinion on comets and their motion. Unfortunately, Grassi's theory was based on a misunderstanding of how the telescope actually works., Vladimír Štefl., and Obsahuje bibliografii
The paper deals with graph operators-the Gallai graphs and the anti-Gallai graphs. We prove the existence of a finite family of forbidden subgraphs for the Gallai graphs and the anti-Gallai graphs to be H-free for any finite graph H. The case of complement reducible graphs-cographs is discussed in detail. Some relations between the chromatic number, the radius and the diameter of a graph and its Gallai and anti-Gallai graphs are also obtained.
Described are the principles of calculation, the methodology and the results of laboratory tests of grazing incidence mirrors used in solar X-ray telescopes installed in rockets "Vertikal 8" (1979), "Vertikal 9" (1981) and "Vertikal 11" (1983) launched as part of the
Intercosmos programme. The X-ray grazing incidence mirrors were developed in the Astronomical Institute of the Czechoslovak Academy of Sciences using galvanoplastic replica technology and tested in the Lebedev Institute of Physics of the USSR Academy of Sciences according to a chart design with one of the investigated mirrors acting as a collimator. The advantages and drawbacks
of this test method of X-ray mirrors are analysed.
Principles of gamma-ray-based measurement are summarized and their application is demonstrated on an operation of the radiometric facility installed in the test loop for slurry flows at the Institute of Hydrodynamics. The facility is able to measure vertical profiles of chord-averaged concentrations and concentration maps in the pipe cross section. A methodology of measurement is proposed including detection and quantification of random and systematic errors. Experimental results are discussed in the light of the proposed methodology. Experimentally determined vertical profiles of concentration are presented for slurry flows of four different fractions of glass beads. The tomographic application of the radiometric device is demonstrated on a measured concentration map and a suitable image reconstruction method is tested. High reliability of measured concentration distributions is proved except for regions near the pipe wall. The radiometric method is shown to be a useful tool for measurement of concentration distribution in slurry flow through a pipe.