It is generally accepted that angiotensin II plays an important role in high blood pressure (BP) development in both 2-kidney-1- clip (2K1C) Goldblatt hypertension and in partial nephrectomy (NX) model of chronic kidney disease (CKD). The contribution of sympathetic nervous system and nitric oxide to BP control in these models is less clear. Partial nephrectomy or stenosis of the renal artery was performed in adult (10-week-old) male hypertensive heterozygous Ren-2 transgenic rats (TGR) and normotensive control Hannover Sprague Dawley (HanSD) rats and in Wistar rats. One and four weeks after the surgery, basal blood pressure (BP) and acute BP responses to the consecutive blockade of renin-angiotensin (RAS), sympathetic nervous (SNS), and nitric oxide (NO) systems were determined in conscious rats. Both surgical procedures increased plasma urea, a marker of renal damage; the effect being more pronounced following partial nephrectomy in hypertensive TGR than in normotensive HanSD rats with a substantially smaller effect in Wistar rats after renal artery stenosis. We demonstrated that the reninangiotensin system does not play so fundamental role in blood pressure maintenance during hypertension development in either CKD model. By contrast, a more important role is exerted by the sympathetic nervous system, the activity of which is increased in hypertensive TGR-NX in the developmental phase of hypertension, while in HanSD-NX or Wistar-2K1C it is postponed to the established phase. The contribution of the vasoconstrictor systems (RAS and SNS) was increased following hypertension induction. The role of NO-dependent vasodilation was unchanged in 5/6 NX HanSD and in 2K1C Wistar rats, while it gradually decreased in 5/6 NX TGR rats.
The event runoff coefficient (Rc) and the recession coefficient (tc) are of theoretical importance for understanding catchment response and of practical importance in hydrological design. We analyse 57 event periods in the period 2013 to 2015 in the 66 ha Austrian Hydrological Open Air Laboratory (HOAL), where the seven subcatchments are stratified by runoff generation types into wetlands, tile drainage and natural drainage. Three machine learning algorithms (Random forest (RF), Gradient Boost Decision Tree (GBDT) and Support vector machine (SVM)) are used to estimate Rc and tc from 22 event based explanatory variables representing precipitation, soil moisture, groundwater level and season. The model performance of the SVM algorithm in estimating Rc and tc is generally higher than that of the other two methods, measured by the coefficient of determination R2, and the performance for Rc is higher than that for tc. The relative importance of the explanatory variables for the predictions, assessed by a heatmap, suggests that Rc of the tile drainage systems is more strongly controlled by the weather conditions than by the catchment state, while the opposite is true for natural drainage systems. Overall, model performance strongly depends on the runoff generation type.
Growth and development rates in many insects are affected by photoperiod, which enables insects to synchronize their life histories with seasonal events, but this aspect of insect photoperiodism remains understudied. Here we use several experimental combinations of constant day length and temperature to determine whether there are quantitative developmental responses to photoperiod in the bug Scantius aegyptius and leaf beetle Timarcha tenebricosa. The thermal ecology of these two species is strikingly different: the former is thermophilic and active throughout summer and the latter is spring-active and avoids the hottest time of the year. In accordance with their contrasting natural thermal environments, S. aegyptius survives better and achieves a larger final body mass at the high experimental temperatures, while T. tenebricosa survives better and is heavier at the low experimental temperatures. Despite this polarity, long-day conditions accelerate larval development relative to a short-day photoperiod in both species, and this developmental response is stronger at low temperatures. Our re-visitation of previous literature in light of the new findings indicates that this similarity in photoperiodic response is superficial and that relatively faster development in midsummer is likely to have a different ecological role in summer- and spring-active species. In the former, it may allow completion of an additional generation during the favourable season, whereas in the latter, this acceleration likely ensures that the larval stage, which is vulnerable to heat, is completed before the onset of hot weather., Dmitry Kutcherov, Elena B. Lopatina, Sergei Balashov., and Obsahuje bibliografii
Objective. The Cooper-Norcross Inventory of Preferences (C-NIP) is a new and promising tool for measuring clients’ preferences regard-ing psychotherapy. However, the psychometric evaluation of this measure is scarce in general and completely missing for the Czech adapta-tion of the measure. This study aimed to test the Czech version of the C-NIP factor structure, test its measurement invariance, and establish cut points. Methods.N = 772 adults answered the C-NIP in an online survey. Confirmatory and explora-tory factor analyses were used to test the fac-tor structure and assess the C-NIP measurement invariance between men and women and across several levels of psychotherapy experience.Results. The original four-factor model was not supported. Instead, a five-factor model was sug-gested that fit the data adequately and was strict-ly invariant with respect to gender and levels of experience with psychotherapy. Conclusions. The Czech C-NIP can be con-sidered a valid and reliable measure of clients’ preferences regarding psychotherapy. The repli-cation of the new factor model is needed. and Cíl. Cooper-Norcross Inventory of Preferences (C-NIP) představuje nejnovější a slibný nástroj určený k měření preferencí klientů ve vztahu k psychoterapii. Psychometrické zhodnocení to-hoto nástroje je však zatím sporé a u české verze zcela chybí. Cílem této studie bylo ověřit fakto-rovu strukturu české verze C-NIP, ověřit invari-anci měření a stanovit hraniční skóry. Metody.N = 772 dospělých respondentů vypl-nilo C-NIP v online průzkumu. K ověření fak-torové struktury a invariance měření mezi po-hlavími a napříč různými úrovněmi zkušenosti s psychoterapií byla použita konfirmační fakto-rový analýza. Výsledky. Původní faktorová struktura nebyla podpořena. Namísto toho byl navržen pětifak-torový model, který vykazoval adekvátní shodu s daty a byl striktně invariantní ve vztahu k po-hlaví i úrovni zkušenosti s psychoterapií. Závěr. Českou verzi C-NIP lze považovat za validní a reliabilní nástroj na měření preferencí klientů ve vztahu k psychoterapii. Je zapotřebí replikovat navrženou faktorovou strukturu.
The usurpation of house martin nests by house sparrows has previously been reported. However, our study demonstrates how neighbouring house martins cooperatively defended against nest-usurping attempts by house sparrows. House martins collectively helped a conspecific pair build their nest at a much faster pace than would be possible for the breeding pair alone, within several hours as compared to a couple of days, in order to overcome the continued attempts of house sparrows to usurp the partially built nest. In our study, between the two breeding seasons of 2018 and 2019, the number of breeding house martins at the study site decreased by almost 63% while in contrast the number of house sparrow breeding pairs increased almost sixfold. The number of usurped nests by house sparrows was comparatively higher in 2019 as compared to 2018.
The occurrence of river floods is strongly related to specific climatic conditions that favor extreme precipitation events leading to catchment saturation. Although the impact of precipitation and temperature patterns on river flows is a well discussed topic in hydrology, few studies have focused on the relationship between peak discharges and standard Climate Change Indices (ETCCDI) of precipitation and temperature, widely used in climate research. It is of interest to evaluate whether these indices are relevant for characterizing and predicting floods in the Alpine area. In this study, a correlation analysis of the ETCCDI indices annual time series and annual maximum flows is presented for the Piedmont Region, in North-Western Italy. Spearman’s rank correlation is used to determine which ETCCDI indices are temporally correlated with maximum discharges, allowing to hypothesize which climate drivers better explain the interannual variability of floods. Moreover, the influence of climate (decadal) variability on the tendency of annual maximum discharges is examined by spatially correlating temporal trends of climate indices with temporal trends of the discharge series in the last twenty years, calculated using the Theil-Sen slope estimator. Results highlight that, while extreme precipitation indices are highly correlated with extreme discharges at the annual timescale, with different indices that are consistent with catchment size, the decadal tendencies of extreme discharges may be better explained by the decadal tendencies of the total annual precipitation over the study area. This suggests that future projections of the annual precipitation available from climate models simulations, whose reliability is higher compared to precipitation extremes, may be used as covariates for non-stationary flood frequency analysis.
Myxobolus pseudodispar Gorbunova, 1936 (Myxozoa) is capable of infecting and developing mature myxospores in several cyprinid species. However, M. pseudodispar isolates from different fish show up to 5% differences in the SSU rDNA sequences. This is an unusually large intraspecific difference for myxozoans and only some of the muscle-dwelling myxozoan species possess such a high genetic variability. We intended to study the correlation between the host specificity and the phylogenetic relationship of the parasite isolates, and to find experimental proof for the putatively wide host range of M. pseudodispar with cross-infection experiments and phylogenetic analyses based on SSU rDNA. The experimental findings distinguished 'primary' and less-susceptible 'secondary' hosts. With some exceptions, M. pseudodispar isolates showed a tendency to cluster according to the fish host on the phylogenetic tree. Experimental and phylogenetic findings suggest the cryptic nature of the species. It is likely that host-shift occurred for M. pseudodispar and the parasite speciation in progress might explain the high genetic diversity among isolates which are morphologically indistinguishable., Barbara Forró, Edit Eszterbauer., and Obsahuje bibliografii
The recent COVID-19 pandemic is the defining global health crisis of our time and little is known about this disease. It has been reported that advanced age is considered a major risk factor for COVID-19 complications, and data suggest that this disease is deadlier for men than women but these observations are currently unclear. Regarding androgen action, it has been shown that certain smooth muscles are a target for androgens by inducing an acute relaxing effect in airway and vascular tissues that is nongenomically mediated; likewise, androgens are capable of inducing genomic anti-inflammatory and nongenomic hypotensive responses. The aim of this report is to associate the relationship between COVID-19 and aging men as well as the comorbidities presented in this group of patients linked with androgen deficiency. Remarkably, the nongenomic mechanisms of androgens as potential protectors are reviewed. On this basis, it is suggested that hypotestosteronemia may be a risk factor for COVID-19 severity.
North to south migration in the U.S. and housing developers’ claims of benefits led to exponential growth in neighbourhood homeowners associations during recent decades. Sanctioned by state laws, association rules governing homeowners are usually initiated by developers who claim that the rules protect property values. But the claim is not supported by empirical analysis. Inflation adjusted annual percentage returns in consecutive sales of a sample of 900 most recent home sales in Duval County Florida, Pima County Arizona and St. Louis County Missouri during late 2017 and early-2018 were examined. The results revealed that the annual percentage returns on homes sold in homeowners associations were significantly less than those of homes in other neighbourhoods statistically controlling for property characteristics and prevailing economic conditions at the time of the original purchase. Correlates of home prices at any point in time are not predictive of percentage return from purchase to sale.
The cough reflex is an airway defensive process that can be
modulated by afferent inputs from organs located also out of the
respiratory system. A bidirectional relationship between cough
and heart dysfunctions are presented in the article, with the
special insights into an arrhythmia-triggered cough. Albeit rare,
cough induced by cardiac pathologies (mainly arrhythmias)
seems to be an interesting and underestimated phenomenon.
This condition is usually associated with the presence of
abnormal heart rhythms and ceases with successful treatment of
arrhythmia either by pharmacotherapy or by radiofrequency
ablation of arrhythmogenic substrate. The two main hypotheses
on cough-heart relationships – reflex and hemodynamic - are
discussed in the review, including the authors’ perspective based
on the experiences with an arrhythmia-triggered cough.