The effect of antigenic bacterial lysate IRS-19 on the recovery of blood cells was studied in mice injured by a single dose of 7 Gy irradiation. The preirradiation administration of IRS-19 accelerated the recovery of leukocytes, reticulocytes and platelets in peripheral blood. The recovery of leukocytes 9-14 days after irradiation in protected animals was accompanied by a higher level of band forms of granulocytes as well as activated lymphoid and monocytoid cells., N.O. Macková, P. Fedoročko., and Obsahuje bibliografii
Autor v tomto recenzním článku představuje a porovnává tři publikace věnované uprchlickému exodu ze severního Řecka do zemí sovětského bloku v důsledku řecké občanské války v letech 1946 až 1949. Zatímco anglojazyčná kniha se soustředí na tehdejší evakuaci dětí z oblastí ohrožených válkou a má ambici zmapovat tyto události v jejich celkovém rozsahu, obě české práce se omezují na popis vln řecké dětské i dospělé imigrace do Československa a pozdějšího života uprchlíků v hostitelské zemi. Dvě prvně uvedené publikace bohatě využívají jako pramen výpovědi pamětníků, přičemž anglojazyčná publikace je pokročilejší v aplikaci nejnovějších metod orální historie a teoreticky přínosnější, nicméně česká kolektivní publikace zdařile plní záměr poskytnout dílčí, ale plastické sondy do problematiky. Samostatná práce Konstantinose Tsivose je od obou svým zaměřením i metodou značně odlišná, jedná se o faktograficky založenou historickou studii s výrazným podtextem sociálních dějin, která nepracuje s prameny orální historie., The author of this review compares and contrasts three publications on the exodus of refugees from northern Greece to the countries of the Soviet bloc in consequence of the Greek Civil War, from 1946 to 1949. Whereas the Danforth and van Boeschoten publication concentrates on the children evacuated from areas threatened by war at that time, and seeks to chart out these events to their full extent, the two Czech works limit themselves to a consideration of the wave of Greek children and adult refugees to Czechoslovak and their later life in the host country. The first two publications make extensive use of the recollections of eyewitnesses, though the publication by Danforth and van Boeschoten is more advanced in the application of the latest methods of oral history and is theoretically more useful. Nevertheless, the essay collection by Kateřina Králová, Konstantinos Tsivos, and others, whose title translates as ‘We have no tears left to cry: Greek refugees in Czechoslovakia’, achieves its aim of providing a vivid, if incomplete, picture of research on the topic. Both in its aims and in its methods the work authored by Tsivos alone is markedly different from the other two books under review. It is a historical study based on fact with a distinctive undercurrent of social history, and ignoring oral-history sources., [autor recenze] Dalibor Vácha., and Obsahuje bibliografii
Red palm oil (RPO) is a rich natural source of antioxidant vitamins, namely carotenes, tocopherols and tocotrienols. However, it contains approximately 50 % saturated fatty acids the regular consumption of which could negatively modify lipid profile. The aim of our study was to test whether 7 weeks of RPO supplementation (1 g/kg body weight/day) would affect blood glucose and lipid metabolism in adult male Wistar rats with altered thyroid status. We induced hypothyroidism and hyperthyroidism in rats by oral administration of either methimazole or mixture of thyroid hormones. Different thyroid status (EU - euthyroid, HY - hypothyroid and HT - hyperthyroid) was characterized by different serum thyroid hormones levels (total and free thyroxine and triiodothyronine), changes in the activity of a marker enzyme of thyroid status - liver mitochondrial glycerol-3-phosphate dehydrogenase, and altered absolute and relative heart weights. Fasting blood glucose levels were higher in HT rats in comparison with EU and HY rats, but the changes caused by RPO supplementation were not significant. The achievement of the HY status significantly increased serum levels of total cholesterol, as well as with high-density lipoproteincholesterol and low-density lipoprotein-cholesterol: 2.43±0.15, 1.48±0.09, 0.89±0.08 mmol/l, compared to EU: 1.14±0.06, 0.77±0.06, 0.34±0.05 mmol/l and HT: 1.01±0.06, 0.69±0.04, 0.20±0.03 mmol/l, respectively. RPO supplementation did not increase significantly levels of blood lipids but tended to increase glutathione levels in the liver. In conclusion, RPO supplementation did not induce the presumed deterioration of glucose and lipid metabolism in rats with three well-characterized alterations in thyroid status., H. Rauchová, M. Vokurková, S. Pavelka, I. Vaněčková, N. Tribulová, T. Soukup., and Seznam literatury
Increased amount of collagen type I and decreased amount of type III is described in various pathological processes in the vascular wall. Polyphenols were shown to have protective effect on endothelium, decrease blood pressure and prevent oxidative damage induced by various stimuli. Tetrachlormethane (CCl4) is a toxic substance with known negative systemic effects induced by free radicals. Chronic administration of CCl4 for 12 weeks led to an increase of collagen type I and a decrease of type III in the wall of aorta. Parallel administration of red wine polyphenols significantly reduced the increase of collagen type I, at the same time the content of type III rose to the level above controls. After 4 weeks of spontaneous recovery no changes were observed. If polyphenols were administered during the recovery period, there was a decrease of type I and an increase of type III collagen content in the aorta. It can be concluded that polyphenols have a tendency to lower the amount of type I and to increase the proportion of type III collagen in the wall of the aorta. These changes are significant in prevention or in regression of changes induced by chronic oxidative stress. This effect of polyphenols is most likely the result of their influence on MMP-1 and TIMP activities through which they positively influence the collagen types I and III content ratio in the vascular wall in favor of the type III collagen., L. Hlavačková ... [et al.]., and Obsahuje seznam literatury
The aim of the present study was to investigate the mechanism of vasorelaxant responses induced by red wine polyphenolic compounds (Provinol). Rings of rat femoral artery with or without functional endothelium were set up in a myograph for isometric recording and precontracted with phenylephrine (10-5 M). Provinol in cumulative doses (10-9 to 10-3 mg/ml) elicited endothelium- and dose-dependent relaxation of the artery with maximal relaxation of 56 % at the concentration of 10-5 mg/ml. The relaxant responses to Provinol correlated well with the increase of NO synthase activity in the vascular tissue after administration of cumulative doses of Provinol (10-9 to 10-3 mg/ml). NG-nitro-L-arginine methylester (L-NAME, 3x10-4 M) significantly attenuated the endothelium-dependent relaxation produced by Provinol. Administration of L-arginine (3x10-5 M) restored the relaxation inhibited by L-NAME. The relaxant responses of Provinol were abolished in the presence of Ca2+-entry blocker, verapamil (10-6 M). Administration of hydrogen peroxide (H2O2) abolished acetylcholine (10-5 M)-induced relaxation of the rat femoral artery, while administration of Provinol (10-5 mg/ml) together with H2O2 helped to maintain the acetylcholine-induced relaxation. Provinol only partially affected the concentration-response curve for the NO donor sodium nitroprusside-induced relaxation in rings without endothelium. In conclusion, Provinol elicited endothelium-dependent relaxation of rat femoral artery by the Ca2+-induced increase of NO synthase activity and by protecting NO from degradation., W. Zenebe, O. Pecháňová, R. Andriantsitohaina., and Obsahuje bibliografii