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4852. DISSERTATIONES MISCELLANEAE, AD Aliquot controversas Juris-Consultoru[m] & Politicorum sententias ...
- Creator:
- Johann Christoph Schambogen, Jiří Černoch, Kyblín z Waffenburka, Daniel František, and Francisco Eusebio de Pötting
- Publisher:
- Černoch, Jiří
- Format:
- print and [24] ff ; 4°
- Type:
- model:monograph and TEXT
- Subject:
- století 17., právo, and 094
- Language:
- Latin
- Description:
- BCBT41746
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
4853. Disticha certis literarum notis annos a Christonato experimentia
- Creator:
- Crinitus z Hlaváčova, David, Mitis z Limuz, Tomáš, and Kozel, Jan
- Format:
- Type:
- volume, model:monograph, and TEXT
- Language:
- Latin
- Description:
- VISK6 - 2013
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
4854. DISTICHA CERTIS LITERARVM
- Creator:
- David Crinitus z Hlaváčova, Matouš Collinus, Tomáš Mitis z Limuz, and Jan Kozel
- Publisher:
- Mitis z Limuz, Tomáš and Kozel, Jan - sen.
- Format:
- print and [16] ff ; 4°
- Type:
- model:monograph and TEXT
- Subject:
- II., římskoněmecký císař, Maxmilián, 1527-1576, imperatrix Romanorum, Maria -, 1528-1603, Venceslaus, století 16, poezie, Rakousko, Rakovník (Česko), přípisky, humanismus, and 094
- Language:
- Latin
- Description:
- Portréty převzaty z kroniky o založení země české od Martina Kuthena ze Šprinsberka., Varianta na fol. A 2r: ... Bohemiæ Regi, ... (místo Regij), Biblioteca Apostolica Vaticana Roma IT Palatina. IV.1056 (int.2), Biblioteca Angelica Roma IT YY.7.6., Pragæ excudebant M. Thomas Mitis, & Ioannes Caper., and BCBT31336
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
4855. Distinct effect of stress on 11β-hydroxysteroid dehydrogenase type 1 and corticosteroid receptors in dorsal and ventral hippocampus
- Creator:
- Ergang, P., Kuželová, A., Matúš Soták, Klusoňová, P., Makal, J., and Jiří Pácha
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, stres (fyziologie), kortikosteroidy, stress (physiology), corticosteroids, 11β-hydroxysteroid dehydrogenase, hippocampus, corticosteroid receptors, 14, and 612
- Language:
- English
- Description:
- Multiple lines of evidence suggest the participation of the hippocampus in the feedback inhibition of the hypothalamus- pituitary-adrenal axis during stress response. This inhibition is mediated by glucocorticoid feedback due to the sensitivity of the hippocampus to these hormones. The sensitivity is determined by the expression of glucocorticoid (GR) and mineralocorticoid (MR) receptors and 11 β -hydroxysteroid dehydrogenase type 1 (11HSD1), an enzyme that re gulates the conversion of glucocorticoids from inactive to active form. The goal of our study was to assess the effect of stress on the expression of 11HSD1, GR and MR in the ventral and dorsal region of the CA1 hippocampus in three different rat strains with diverse responses to stress: Fisher 344, Lewis and Wistar. Stress stimulated 11HSD1 in the ventral but not dorsal CA1 hippocampus of Fisher 344 but not Lewis or Wistar rats. In contrast, GR expression following stress was decreased in the dorsal but not ventral CA1 hippocampus of all three strains. MR expression was not changed in either the dorsal or ventral CA1 region. These results indicate that (1) depending on the strain, stress stimulates 11HSD1 in the ventral hippocampus, which is known to be involved in stress and emotion reactions whereas (2) independent of strain, stress inhibits GR in the dorsal hippocampus, which is predominantly involved in cognitive functions., P. Ergang ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
4856. Distinct effects of acute pretreatment with lipophilic and hydrophilic statins on myocardial stunning, arrhythmias and lethal injury in the rat heart subjected to ischemia/reperfusion
- Creator:
- Slávka Čarnická, Adriana Adameová, Mária Nemčeková, Matejíková, J., Dezider Pancza, and Ravingerová, T.
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, statiny, ischemie, statins, ischemia, water solubility, pleiotropic effects, rat heart, 14, and 612
- Language:
- English
- Description:
- Although both lipophilic and more hydrophilic statins share the same pathway of the inhibition of HMG-CoA reductase, their pleiotropic cardioprotective effects associated with the ability to cross cellular membranes, including membranes of heart cells, may differ. To test this hypothesis, isolated rat hearts were Langendorff-perfused either with simvastatin (S, 10 μ mol/l) or pravastatin (P, 30 μ mol/l), 15 min prior to ischemia. Control untreated hearts (C) were perfused with perfusion medium only. Postischemic contractile dysfunction, reperfusion-induced ventricular arrhythmias and infarct size were investigated after exposure of the hearts to 30- min global isch emia and 2-h reperfusion. Both lipophilic S and hydrophilic P reduced the severity of ventricular arrhythmias (arrhythmia score) from 4.3±0.2 in C to 3.0±0 and 2.7±0.2 in S and P, respectively, (both P<0.05), decreased the duration of ventricular tachycardia and suppressed ventricular fibrillation. Likewise, the extent of lethal injury (infarct size) determined by tetrazolium staining and expressed in percentage of risk area, was significantly lower in both treated groups, moreover, the effect of P was more pronounced (27±2 % and 10±2 % in S and P groups, respectively, vs. 42±1 % in C; P<0.05). In contrast, only S, but not P, was able to improve postischemic recovery of left ventricular developed pressure (LVDP; 48±12 % of preischemic values vs. 25±4 % in C and 21± 7 % in P groups; P<0.05). Our results suggest that differences in water solubility of statins indicating a different ability to cross cardiac membranes may underlie their distinct cardioprot ective effects on myocardial stunning and lethal injury induced by ischemia/reperfusion., S. Čarnická ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
4857. Distinct patterns of histone methylation and acetylation in human interphase nuclei
- Creator:
- Magdalena Skalníková, Eva Bártová, Vladimír Ulman, Pavel Matula, David Svoboda, Andrea Harničarová, Michal Kozubek, and Stanislav Kozubek
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, biomedicína, chromozomy, počítačová analýza obrazu, human physiology, biomedicine, chromosomes, computer image analysis, histone methylation, acetylation, centromeres, 14, and 612
- Language:
- English
- Description:
- To study 3D nuclear distributions of epigenetic hist one modifications such as H3(K9) acetylation, H3(K4) dimethylation, H3(K9) dimethylation, and H3(K27) trimethylation, and of histone methyltransferase Suv39H1, we used advanced image analysis methods, comb ined with Nipkow disk confocal microscopy. Total fluorescence intensity and distributions of fluorescently labelled proteins were analyzed in formaldehyde-fixed interphase nuclei. Our data showed reduced fluorescent signals of H3(K9) acetylation and H3(K4) dimethylation (di-me) at the nuclear periphery, while di-meH3(K9) was also abundant in chromatin regions closely associated with the nuclear envelope. Little overlapping (intermingling) was observed for di-meH3(K4) and H3(K27) trimethylation (tri-me), and for di-meH3(K9) and Suv39H1. The histone modifications studied were absent in the nucleolar compartment with the exception of H3(K9) dimethylation that was closely associated with perinucleolar regions which are formed by centromeres of acrocentric chromosomes. Using immunocytochemistry, no di-meH3(K4) but only dense di-meH3(K9) was found for the human acrocentric chromosomes 14 and 22. The active X chromosome was observed to be partially acetylated, while the inactive X was more condensed, located in a very peripheral part of the interphase nuclei, and lacked H3(K9) acetylation. Our results confirmed specific interphase patterns of histone modifications within the interphase nuclei as well as within their chromosome territories., M. Skalníková, E. Bártová, V. Ulman, P. Matula, D. Svoboda, A. Harničarová, M. Kozubek, S. Kozubek., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
4858. Distinct response of fat and gastrointestinal tissue to glucose in gestational diabetes mellitus and polycystic ovary syndrome
- Creator:
- Daniela Vejražková, Lischkova, O., Marie Vaňková, Stanicka, S., Jana Vrbíková, Petra Lukášová, Josef Včelák, Vacinova, G., and Běla Bendlová
- Format:
- print, bez média, and svazek
- Type:
- article, články, journal articles, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, syndrom polycystických ovarií, inkretiny, polycystic ovary syndrome, incretins, gestational diabetes mellitus, glucose tolerance, adipokines, 14, and 612
- Language:
- English
- Description:
- Gestational diabetes mellitus (GDM) and polycystic ovary syndrome (PCOS) are distinct pathologies with impaired insulin sensitivity as a common feature. The aim of this study was to evaluate the response of fat tissue adipokines and gastrointestinal incretins to glucose load in patients diagnosed with one of the two disorders and to compare it with healthy controls. Oral glucose tolerance test (oGTT) was performed in 77 lean young women: 22 had positive history of GDM, 19 were PCOS patients, and 36 were healthy controls. Hormones were evaluated in fasting and in 60 min intervals during the 3 h oGTT using Bio-Plex ProHuman Diabetes 10-Plex Assay for C-peptide, ghrelin, GIP, GLP1, glucagon, insulin, leptin, total PAI1, resistin, visfatin and Bio-Plex ProHuman Diabetes Adipsin and Adiponectin Assays (Bio-Rad). Despite lean body composition, both PCOS and GDM women were more insulin resistant than controls. Significant postchallenge differences between the GDM and PCOS groups were observed in secretion of adipsin, leptin, glucagon, visfatin, ghrelin, GIP, and also GLP1 with higher levels in GDM. Conversely, PCOS was associated with the highest resistin, C-peptide, and PAI1 levels. Our data suggest that decreased insulin sensitivity observed in lean women with GDM and PCOS is associated with distinct hormonal response of fat and gastrointestinal tissue to glucose load., D. Vejrazkova, O. Lischkova, M. Vankova, S. Stanicka, J. Vrbikova, P. Lukasova, J. Vcelak, G. Vacinova, B. Bendlova., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
4859. Distribuce hodnot glykovaného hemoglobinu v populaci diabetiků 2. typu: projekt Valetudo
- Creator:
- Kvapil, Milan
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, dopisy, and TEXT
- Subject:
- lidé, diabetes mellitus 2. typu--farmakoterapie--krev, hemoglobin A glykosylovaný--analýza--účinky léků, pozorovací studie jako téma, and multicentrické studie jako téma
- Language:
- Czech and English
- Description:
- Pro populaci pacientů s diabetem 2. typu nejsou v současnosti v České republice dostupná data o distribuci hodnot glykovaného hemoglobinu. Plnému uplatnění výhod nových skupin antidiabetik pro časnou intervenci brání v současnosti indikační omezení, které omezuje úhradu této terapie pro nedostatečně kompenzované pacienty s hranicí definovanou hodnotou 60 mmol/mol (6 % IFCC). Analýza distribuce hodnot glykovaného hemoglobinu v náhodně vybrané populaci pacientů s diabetem 2. typu ve studii Valetudo ukazuje, že v rozmezí kritického intervalu od 43 mmol/mol do 80 mmol/mol je průměrná četnost pacientů z celé populace 1,88 %/1 mmol/mol glykovaného hemoglobinu. Interpretace dat z průřezových studií je velmi obtížná, jelikož zahrnuje pacienty před léčbou (případně před intenzifikací léčby) i pacienty úspěšně léčené., Currently, there are no available data on distribution of the values of glycated haemoglobin in patients with type 2 diabetes in the Czech Republic. More frequent, efficacy and early application of new antidiabetic agents is limited by indication criterion which restricts the payment of this therapy for patients with poorly compensated diabetes defined by threshold value of 60 mmol/mol (6% IFCC). The study Valetudo analyzed distribution of glycated haemoglobin values in the random population of patients with type 2 diabetes and showed that within the critical range from 43 mmol/mol to 80 mmol/mol is the average frequency of patients from the whole population of 1.88%/1 mmol/mol glycated haemoglobin. Interpretation of data from cross-sectional studies is very difficult as they involve patients before treatment (possibly before the intensification of therapy) and also patients successfully treated., and Milan Kvapil
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
4860. Distribution and dispersal of the invasive Asian chestnut gall wasp, Dryocosmus kuriphilus (Hymenoptera: Cynipidae), across the heterogeneous landscape of the Iberian Peninsula
- Creator:
- Gil-Tapetado, Diego, Gómez, José F, Cabrero-Sañudo, Francisco J, and Nieves-Aldrey, José L
- Format:
- print, počítač, and online zdroj
- Type:
- model:article and TEXT
- Subject:
- blanokřídlí, Hymenoptera, Pyrenejský poloostrov, Iberian Peninsula, Cynipidae, Dryocosmus kuriphilus, Asian chestnut gall wasp, invasive species, niche models, dispersal, distribution, 2, and 59
- Language:
- English
- Description:
- Dryocosmus kuriphilus (Hymenoptera: Cynipidae), also known as the Asian chestnut gall wasp, is a non-native invasive species that has recently appeared in many regions of Europe, including the Iberian Peninsula. This species is an important pest of chestnut trees in several regions and is of concern for foresters in these areas. The results of this research revealed 14 different hotspots of infestation of D. kuriphilus and resulted in the development of models that predict the distribution of D. kuriphilus in Spain over the next 37 years (2019-2055). These results indicate a rapid spread in all Spanish chestnut forests and identify areas that are theoretically highly suitable and susceptible to colonization by this cynipid based on predictions of three different niche models. Although D. kuriphilus is able to induce galls on all chestnut trees, the models indicate that there are differences in the suitability of the different regions for this species. This differential suitability results in some areas having better environmental conditions than others for D. kuriphilus, which is a factor that should be taken into account in its management and biological control. This study of the current distribution, patterns of dispersal using GIS and potentially suitable areas for D. kuriphilus, using niche models will assist in the management and control of this pest in Spain., Diego Gil-Tapetado, José F. Gómez, Francisco J. Cabrero-Sañudo, José L. Nieves-Aldrey., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public