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212. A note on the multiplier ideals of monomial ideals
- Creator:
- Gong, Cheng and Tang, Zhongming
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- mathematics, multiplier ideal, monomial ideal, convex set, 13, and 51
- Language:
- English
- Description:
- Let a \subseteq \mathbb{C} [x1, ..., xn] be a monomial ideal andJ(a^{c}) the multiplier ideal of a with coefficient c. Then J(a^{c}) is also a monomial ideal of \mathbb{C} [x1, ..., xn], and the equality J(a^{c}) = a implies that 0 < c < n + 1. We mainly discuss the problem when J (a) = a or J({a^{n = 1 - \varepsilon }}) = a for all 0 < ε < 1. It is proved that if J (a) = a then a is principal, and if J({a^{n = 1 - \varepsilon }}) = a holds for all 0 < ε < 1 then a = (x1, ..., xn). One global result is also obtained. Let ã be the ideal sheaf on \mathbb{P}^{n-1} associated with a. Then it is proved that the equality J (ã) = ã implies that ã is principal., Cheng Gong, Zhongming Tang., and Obsahuje seznam literatury
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
213. A novel endosymbiont-containing trypanosomatid Phytomonas borealis sp. n. from the predatory bug Picromerus bidens (Heteroptera: Pentatomidae)
- Creator:
- Ganyukova, Anna I, Frolov, Alexander O, Malysheva, Marina N, Spodareva, Viktoria V, Vyacheslav Yurchenko, and Kostygov, Alexei Yu
- Format:
- print, počítač, and online zdroj
- Type:
- model:article and TEXT
- Subject:
- dravé ryby, predatory fishes, new trypanosomatid species, prokaryotic endosymbionts, non-specific infection, 2, and 59
- Language:
- English
- Description:
- Here we describe the new trypanosomatid, Phytomonas borealis sp. n., from the midgut of the spiked shieldbugs, Picromerus bidens (Linnaeus), collected in two locations, Novgorod and Pskov Oblasts of Russia. The phylogenetic analyses, based on the 18S rRNA gene, demonstrated that this flagellate is a sister species to the secondary monoxenous Phytomonas nordicus Frolov et Malysheva, 1993, which was concurrently documented in the same host species in Pskov Oblast. Unlike P. nordicus, which can complete its development (including exit to haemolymph and penetration into salivary glands) in Picromerus bidens, the new species did not form any extraintestinal stages in the host. It also did not produce endomastigotes, indispensable for transmission in other Phytomonas spp. These observations, along with the fact that P. bidens overwinters at the egg stage, led us to the conclusion that the examined infections with P. borealis were non-specific. Strikingly, the flagellates from the Novgorod population contained prokaryotic endosymbionts, whereas the parasites from the second locality were endosymbiont-free. This is a first case documenting presence of intracellular symbiotic bacteria in Phytomonas spp. We suggest that this novel endosymbiotic association arose very recently and did not become obligate yet. Further investigation of P. borealis and its intracellular bacteria may shed light on the origin and early evolution of endosymbiosis in trypanosomatids., Anna I. Ganyukova, Alexander O. Frolov, Marina N. Malysheva, Viktoria V. Spodareva, Vyacheslav Yurchenko and Alexei Yu. Kostygov., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
214. A novel neuroregenerative approach using ETB receptor agonist, IRL-1620, to treat CNS disorders
- Creator:
- Gulati, A., Hornick, M. G., Lavhale, M. S., and Briyal, S.
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- fyziologie člověka, human physiology, Endothelin, ETB receptors, Neuroregeneration, Alzheimer’s disease, Ischemic stroke, Amyotrophic lateral sclerosis, 14, and 612
- Language:
- English
- Description:
- Endothelin B (ETB) receptors present in abundance the central nervous system (CNS) have been shown to have significant implications in its development and neurogenesis. We have targeted ETB receptors stimulation using a highly specific agonist, IRL-1620, to treat CNS disorders. In a rat model of cerebral ischemia intravenous administration IRL-1620 significantly reduced infarct volume and improved neurological and motor functions compared to control. This improvement, in part, is due to an increase in neuroregeneration. We also investigated the role of IRL-1620 in animal models of Alzheimer’s disease (AD). IRL-1620 improved learning and memory, reduced oxidative stress and increased VEGF and NGF in Aβ treated rats. IRL-1620 also improved learning and memory in an aged APP/PS1 transgenic mouse model of AD. These promising findings prompted us to initiate human studies. Successful chemistry, manufacturing and control along with mice, rat and dog toxicological studies led to completion of a human Phase I study in healthy volunteers. We found that a dose of 0.6 μg/kg of IRL-1620 can be safely administered, three times every four hours, without any adverse effect. A Phase II clinical study with IRL-1620 has been initiated in patients with cerebral ischemia and mild to moderate AD., A. Gulati, M. G. Hornick, S. Briyal, M. S. Lavhale., and Seznam literatury
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
215. A novel stage-specific glycosomal nucleoside diphosphate kinase from Trypanosoma cruzi
- Creator:
- Cámara, María de los Milagros, Bouvier, León, Reigada, Chantal, Digirolamo, Fabio A, Sayé, Melisa, and Pereira, Claudio A
- Format:
- print, počítač, and online zdroj
- Type:
- model:article and TEXT
- Subject:
- energetický metabolismus, energy metabolism, trypanosomatids, Chagas disease, glycosomes, trypomastigotes, 2, and 59
- Language:
- English
- Description:
- Nucleoside diphosphate kinases (NDPK) are key enzymes involved in the intracellular nucleotide maintenance in all living organisms, especially in trypanosomatids which are unable to synthesise purines de novo. Four putative NDPK isoforms were identified in the Trypanosoma cruzi Chagas, 1909 genome but only two of them were characterised so far. In this work, we studied a novel isoform from T. cruzi called TcNDPK3. This enzyme presents an atypical N-terminal extension similar to the DM10 domains. In T. cruzi, DM10 sequences targeted other NDPK isoform (TcNDPK2) to the cytoskeleton, but TcNDPK3 was localised in glycosomes despite lacking a typical peroxisomal targeting signal. In addition, TcNDPK3 was found only in the bloodstream trypomastigotes where glycolytic enzymes are very abundant. However, TcNDPK3 mRNA was also detected at lower levels in amastigotes suggesting regulation at protein and mRNA level. Finally, 33 TcNDPK3 gene orthologs were identified in the available kinetoplastid genomes. The characterisation of new glycosomal enzymes provides novel targets for drug development to use in therapies of trypanosomatid associated diseases., María de los Milagros Cámara, León Bouvier, Chantal Reigada, Fabio A. Digirolamo, Melisa Sayé, Claudio A. Pereira., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
216. A priori a matematika u Berkeleyho
- Creator:
- Marek Tomeček
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Filozofie, Berkeley, George, 1685-1753, filozofie, matematika, empirismus, philosophy, mathematics, empiricism, a priori, 5, and 101
- Language:
- Czech
- Description:
- According to the Oxford English Dictonary George Berkeley introduced the term a priori into English. His inspiration for this was, it seems, to be found partly in the writings of his immediate predecessors, particularly Pierre Bayle, and partly in his pedagogical work where he adjudicated disputations between his pupils. Some of his arguments against the existence of matter Berkeley tells us are a priori, others a posteriori. Even the a priori arguments are underpinned by prior semantic principles of an anti-abstractionist character, which are shown to be important particularly in the immaterialist philosophy of mathematics. Berkeley's courageously unorthodox, and generally unpublished, thoughts about mathematics thus grow from the same soil as his celebrated denial of matter., Marek Tomeček., and Obsahuje poznámky a bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
217. A publishing project of her own - Anna Katharina Sweerts-Sporck as a patroness of the servite order and a promoter of devotional literature
- Creator:
- Čapská, Veronika
- Format:
- print, text, regular print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- 18. století, mecenášství, servité, patronage, Servites, devoční literatura, afektivní zbožnost, devotional literature, affective piety, 8, and 94(437)
- Language:
- Czech
- Description:
- The scholarly attention paid to Anna Katharina SweertsSporck has so far focused on the phase of her youth when she was engaged in translating books chosen by her father count Franz Anton Sporck for publishing. The article explores her interest in the book culture in the later stage of her life after her forced entrance into marriage in 1712. Anna Katharina initiated a large program of publishing and spreading devotional literature. The project was realized in cooperation with the Servite friar Wilhelm M. Löhrer and it aimed to cultivate internal, affective piety as a newly appraised type of religiosity which was increasingly popular across the confessional boundaries in the eighteenth century., Veronika Čapská., and Obsahuje bibliografické odkazy
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
218. A pure smoothness condition for radó’s theorem for α-analytic functions
- Creator:
- Daghighi, Abtin and Wikström, Frank
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- matematika, analytické funkce, mathematics, analytic functions, α-analytic function, polyanalytic function, zero set, Radó’s theorem, 13, and 51
- Language:
- English
- Description:
- Let \Omega \subset {{\Bbb C}^n} be a bounded, simply connected \mathbb{C} -convex domain. Let \alpha \in \mathbb{Z}_{+}^{n} and let f be a function on Ω which is separately {C^{2{\alpha _j} - 1}} -smooth with respect to zj (by which we mean jointly {C^{2{\alpha _j} - 1}} -smooth with respect to Rezj, Imzj). If f is α-analytic on Ω\f−1(0), then f is α-analytic on Ω. The result is well-known for the case a_{i}=1, 1\leqslant i\leqslant n even when f a priori is only known to be continuous., Abtin Daghighi, Frank Wikström., and Obsahuje seznam literatury
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
219. A sharp upper bound for the spectral radius of a nonnegative matrix and applications
- Creator:
- You, Lihua, Shu, Yujie, and Zhang, Xiao-Dong
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- matematika, mathematics, nonnegative matrix, spectral radius, graph, digraph, 13, and 51
- Language:
- English
- Description:
- We obtain a sharp upper bound for the spectral radius of a nonnegative matrix. This result is used to present upper bounds for the adjacency spectral radius, the Laplacian spectral radius, the signless Laplacian spectral radius, the distance spectral radius, the distance Laplacian spectral radius, the distance signless Laplacian spectral radius of an undirected graph or a digraph. These results are new or generalize some known results., Lihua You, Yujie Shu, Xiao-Dong Zhang., and Obsahuje seznam literatury
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
220. A short note on Lq theory for Stokes problem with a pressure-dependent viscosity
- Creator:
- Mácha, Václav
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- matematika, viskozita, mathematics, viscosity, Stokes problem, Lq theory, pressure-dependent viscosity, 13, and 51
- Language:
- English
- Description:
- We study higher local integrability of a weak solution to the steady Stokes problem. We consider the case of a pressure- and shear-rate-dependent viscosity, i.e., the elliptic part of the Stokes problem is assumed to be nonlinear and it depends on p and on the symmetric part of a gradient of u, namely, it is represented by a stress tensor T (Du, p):= v(p, |D|2)D which satisfies r-growth condition with r \in (1, 2]. In order to get the main result, we use Calderón-Zygmund theory and the method which was presented for example in the paper Caffarelli, Peral (1998)., Václav Mácha., and Obsahuje seznam literatury
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public