Aldosterone plays a key role in maintaining the homeostasis of the whole organism. Under some circumstances, aldosterone can contribute to the progression of cardiovascular diseases, including coronary artery disease. This study demonstrates that aldosterone associates negatively with some lipidogram parameters and positively with the concentration of homocysteine. These associations are characteristic for coronary artery disease and are not present in control subjects. The findings also indicate that in vitro aldosterone stimulates homocysteine production by rat adrenal glands, which may explain the associations observed with coronary artery disease. Moreover, we have found that aldosterone significantly modulates in vitro platelet reactivity to arachidonate and collagen - aldosterone increases the pro-aggregatory action of collagen, but decreases the pro-aggregatory potential of arachidonate. Therefore, the findings of these in vitro and ex vivo experiments indicate the existence of new pathways by which aldosterone modulates lipid- homocysteine- and platelet-dependent atherogenesis., K. Karolczak, P. Kubalczyk, R. Glowacki, R. Pietruszynski, C. Watala., and Seznam literatury
Práce podává přehled práce francouzského experimentálního psychologa Alfreda Bineta (1857–1911) v oblasti studia disociačních jevů. V úvodu jsou uvedeny základní profesní a biografické údaje a dále popis jeho díla v oblasti studia hypnózy, hysterie a obecně problematiky disociačních jevů. Pozornost je věnována hlavním dílům k této problematice, která jsou popisována chronologicky a v souvislosti s Binetovým odborným vývojem i širší situací v oboru psychologie. Práce představuje méně známé dílo francouzského psychologa přelomu 19. a 20., který se proslavil především studiem teorie a měření inteligence., The article reviews works of famous experimental psychologist Alfred Binet (1857-1911) in the area of dissociative phenomena studies. Introductory part of the article provides the basic professional and biographic information and further description of Binet’s work in the area of hypnosis, hysteria and generally area of dissociative phenomenon is given. Special attention is given to the main books written on these topics. The works are described in chronological order and in relation to Binet’s professional development. The article presents less known work of famous French psychologist of turn of 19th and 20th century, famous above all with the studies of intelligence., Radek Ptáček., and Obsahuje seznam literatury