In spite of the complicated plurality of the present ways of thinking about speech and the prerequisites of speech, it is possible to say that the various ways of thinking could be placed somewhere between the end points the „absolute“ formalism and the „consistent“ functionalism with the distinct transitional zone in between. One can assume that the development tends from the formalism to the functionalism and this means the way of rising of the explanatory power of the theories. In order to make the process successful it is necessary to look for such formal means that are able to rationally express the knowledge of consistent functionalistic theories. If it were not for this fact, the way from the „absolute“ formalism to the „consistent“ functionalism would be the unwished way from the rationalism to non-rationalistic speculations, far away from the bounds of science. If we insisted on the petrification of the so far existed formalisms, in the name of the aimed grade of formalisation, it would mean to persist on the knowledge of speech on interest of the brilliant formal language exercises.
Antagonists of GABA B receptors are expected to have proconvulsant acti on also in developing brain. Two antagonists (CGP55845 and CGP46381) were tested in a model of cortical epileptic afterdischarges (ADs) in 12-, 18- and 25-day-old rat pups with implanted electrodes. CGP55845 was dissolved in dimethylsulfoxide and the results demonstrated marked proconvulsant action of this solvent which masked possible action of the antagonist. Water soluble antagonist CGP46381 led to marked potentiation of ADs in 12-day-old animals, its action decreased with age, it was negligible in 25-day-old rats. Our results demonstrated important inhibitory role of GABA B receptors at very early stages of maturation., P. Mareš., and Obsahuje bibliografii a bibliografické odkazy
sepsal Ladislav Čelakovský, Obsahuje přívazek: Prodromus květeny české. Díl třetí, obsahující dvouděložné prostoplátečné / sepsal Ladislav Čelakovský, and Converted from MODS 3.5 to DC version 1.8 (EE patch 2015/06/25)
In this paper we analyse a definition of a product of Banach spaces that is naturally associated by duality with a space of operators that can be considered as a generalization of the notion of space of multiplication operators. This dual relation allows to understand several constructions coming from different fields of functional analysis that can be seen as instances of the abstract one when a particular product is considered. Some relevant examples and applications are shown, regarding pointwise products of Banach function spaces, spaces of integrable functions with respect to vector measures, spaces of operators, multipliers on Banach spaces of analytic functions and spaces of Lipschitz functions., Enrique A. Sánchez Pérez., and Obsahuje seznam literatury
Matrix metalloproteinases (MMPs) is a family of proteolytic enzymes involved in remodeling of extracellular matrix. Although proteolytic enzymes are produced by many cell types, mast cells seem to be more important than other types in remodeling of pulmonary arteries during hypoxia. Therefore, we tested in vitro production of MMPs and serine proteases in four cell types (mast cells, fibroblasts, vascular smooth muscle cells and endothelial cells) cultivated for 48 h under normoxic or hypoxic (3 % O2) conditions. MMP-13 was visualized by immunohistochemistry, MMP-2 and MMP-9 were detected by zymography in cell lysates. Enzymatic activities (MMPs, tryptase and chymase) were estimated in the cultivation media. Hypoxia had a minimal effect on total MMP activity in the cultivation media of all types of cells, but immunofluorescence revealed higher intensity of MMP-13 in the cells exposed to hypoxia except of fibroblasts. Tryptase activity was three times higher and chymase activity twice higher in mast cells cultivated in hypoxia than in those cultured in normoxia. Among all cell types studied here, mast cells are the most abundant source of proteolytic enzymes under normoxic and hypoxic conditions. Moreover, in these cells hypoxia increases the production of both specific serine proteases tryptase and chymase, which can act as MMPs activators., H. Maxová ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy