The aim of the present text is to consider 18th century language genealogies, as proposed by Rousseau and Condillac, in relation to the question of gesture and affectivity. For it seems that a certain form of affect - need in Condillac, passion in Rousseau - comes to play a central role in the speculations concerning the possible origin of human communication whose nature is invariably considered to be gestural as well as vocal. Our aim will be to show that the insights both thinkers present on the subject corresponds, quite remarkably, with certain findings of modern linguistics and psychology. It is, of course, impossible to treat the issue in all its complexity; all that we will attempt to do is concentrate on certain significant passages and pinpoint what we consider to be the most remarkable arguments., Josef Fulka., and Obsahuje bibliografické odkazy
Ghrelin is a new endogenous peptide, discovered in 1999 by Kojima et al., as the result of a search for an endogenous ligand for an orphan receptor of known structure and function. Ghrelin is composed of 28 amino acids and is produced mostly by cells of the stomach, hypothalamus, and hypophysis, but it has also been detected in other tissues. Its discovery is related to the development of a new hypothesis regarding the regulation of growth hormone secretion. It is an antagonist of somatostatin. Ghrelin activates the release of growth hormone from the somatotrophic cells of the hypophysis. It participates in the regulation of energy homeostasis, increases food intake, decreases energy output and exerts a lipogenetic effect. Its metabolic effects do not depend on the GH/IGF-I system, but are mediated by the NPY/Y1 and AGRP receptor system. Ghrelin influences the secretion and motility of the gastrointestinal tract, especially the stomach. The presence of ghrelin and its receptors has also been demonstrated in many other tissues. Its function in these tissues has not yet been studied, thus providing many possibilities for further research., M. Rosická, M. Kršek, Z. Jarkovská, J. Marek, V. Schreiber., and Obsahuje bibliografii