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6302. Evidence knihovních fondů a evidence činnosti v knihovnách jednotné soustavy

Creator:
Vojtek, Zdeněk
Publisher:
Krajská knihovna Maxima Gorkého
Format:
print and 21 s. : il. ; 21 cm
Type:
model:monograph, Text, metodické příručky, volume, and TEXT
Subject:
veřejné knihovny, veřejné knihovny--Česko, evidence knihovních fondů, evidence knihovních fondů--Česko, činnost knihoven, činnost knihoven--Česko, 027, 025, 005.912, and 021
Language:
Czech
Description:
zpracoval Zdeněk Vojtek, Název z obálky, and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

6303. Evidence of euryhalinity of the gulf corvina (Cynoscion othonopterus)

Creator:
Perez-Velazquez, M., Urquidez-Bejarano, P., González-Félix, M. L., and Minjarez-Osorio, C.
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, životní prostředí, fyziologie, environment, physiology, salinity, osmolality, euryhaline, cynoscion othonopterus, 14, and 612
Language:
English
Description:
The effects of environmental salinity on physiological responses, growth, and survival of the Gulf corvina, C. othonopterus, were evaluated in a 6-week completely randomized design experiment. Corvina (17.2±2.3 g mean initial body weight) were subjected to salinities of 5, 15, 25, and 35 ‰ and fed a commercial feed with protein and lipid contents of 46 and 14 %, respectively. Plasma osmolality increased significantly with salinity, ranging from 335.1±5.3 mOsm/kg in fish maintained at 5 ‰, to 354.8±6.8 mOsm/kg in fish kept in seawater, while a significant inverse relationship was observed between salinity and moisture content of whole fish, ranging from 73.8±0.7 (measured at 5 ‰) to 76.9±1.0 % (measured at 35 ‰). In spite of this, growth indices (final weight, weight gain, specific growth rate, condition factor, survival) were not altered, suggesting that, like other members of the family Sciaenidae, the Gulf corvina is a strong osmoregulator. The isosmotic point for this species was estimated to correspond to a salinity of 9.8 ‰. The present study represents the first set of experimental data on salinity tolerance of C. othonopterus and confirms the euryhalinity of this species., M. Perez-Velazquez, P. Urquidez-Bejarano, M. L. González-Félix, C. Minjarez-Osorio., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

6304. Evidence of host blood feeding by the monogenean, Ancyrocephalus mogurndae (Monogenea: Ancyrocephalidae) from the gills of the mandarin fish, Siniperca chuatsi

Creator:
Gao, Qian, Nie, Pin, and Yao, Wei J.
Format:
print
Type:
model:internalpart and TEXT
Subject:
Monogenea, Ancyrocephalus mogurndae, blood ingestion, iron content, mandarin fish, and Siniperca chuatsi
Language:
English
Description:
By examining iron contents, it is demonstrated that the monogenean Ancyrocephalus mogurndae (Yamaguli, 1940) feeds on the blood of its host, the mandarin fish Siniperca chuatsi (Basilcwsky), The iron content and then the quantity of blood necessary to produce this amount of iron are found different in young and fully-matured worms. Young worms contain higher levels of iron and estimated amount of blood. It is suggested that/1, mogurndae may start to feed on host blood as attached on gills, and the amount of blood ingested by young worms may vary from 0.01 to 1.00 μΙ before reproduction. The difference between young and fully-malurcd worms may be accounted for by the elimination of haematin and change of food composition in matured worms and may also be affected by reproduction. Experimental infections of the monogenean may provide supportive information for explaining the difference, and further studies should also examine the effect of immune components in host blood or mucus on the intestines of the parasite.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

6305. Evidences of apoptosis during the early phases of soleus muscle atrophy in hindlimb suspended mice

Creator:
Fabiane Mendonça Ferreira, Neuparth, M. J., Vittorino, R., Appell, H. J., Amado, F., and Duarte, J. A.
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, fyziologie, mitochondrie, buněčná smrt, svalová atrofie, physiology, mitochondrias, cell death, muscular atrophy, unloading, muscle ultrastructure, 14, and 612
Language:
English
Description:
The purpose of this study was to investigate the occurrence and time-course of apoptosis in soleus skeletal muscle during the first 48 hours of unloading. Fifty Charles River mice were randomly divided into five groups (n=10 each) according to the time of hindlimb suspension (HS). Mice we re suspended for 0 (Control), 6 (6HS), 12 (12HS), 24 (24HS), and 48 hours (48HS). Soleus muscle atrophy was confirmed by a significant decrease of 20 % in muscle-wet weight and of 5 % in the ratio protein concentration/muscle wet-weight observed after 48 hours of unloading. The apoptotic index, the AIF (apoptosis-inducing factor) and p53 expression presented th eir uppermost value (304 %, 241 % and 246 %, respectively) at 24HS, and were preceded by the highest activity of caspase-3 and -8 at 12HS (170 % and 218 %, respectively) and of Bax/Bcl-2 content at 6HS (160 %). There were no marked ultrastructural alterations until 24 hours of simulated weightlessness. Lysosomal autophagic activity and infiltration of phagocytic cells were observed at 24HS and 48HS and might have contributed to the degenerative changes noticed in both groups. Though not consistently supported by morphological evidences, the biochemical parameters sustain the concept that the occurrence of apoptosis parallels the soleus atrophic response in its early phase., R. Ferreira, M. J. Neuparth, R. Vittorino, H. J. Appell, F. Amado, J. A. Duarte., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

6306. Evidencia v analytickej filozofii

Creator:
Marián Zouhar
Format:
print
Type:
article, články, model:article, and TEXT
Subject:
Filozofie, analytická filozofie, intuice, analytical philosophy, intuition, evidence in philosophy, richness of intuitions, specifity of intuitions, transparency of intuitions, 5, and 101
Language:
Czech
Description:
It is often supposed that linguistic, conceptual and, perhaps, other kinds of intuitions are one of the most important tools used to test theories in analytical philosophy. On this view, intuitions thought to be rich enough to be applicable to all the data the philosopher has used in formulating and testing her theory; but specific enough to enable one to choose between competing theories; and transparent enough to be clearly relevant for the theory. In the light of certain examples from epistemology and philosophy of language, it is claimed here that these requirements are not met. Consequently, evaluation of philosophical theories on the basis of intuitions leads to unreliable and problematic results., Marián Zouhar., and Obsahuje poznámky a bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

6308. Evolokumab a projekt PROFICIO: první výsledky

Creator:
Kraml, Pavel
Format:
print, text, and regular print
Type:
model:article, article, Text, přehledy, and TEXT
Subject:
lidé, analýza podle původního léčebného záměru--statistika a číselné údaje, klinické zkoušky, fáze III - jako téma, statistika jako téma, výsledek terapie, hypolipidemika--aplikace a dávkování--terapeutické užití, injekce subkutánní, LDL-cholesterol--krev--účinky léků, hypercholesterolemie--farmakoterapie, hyperlipoproteinemie typ II--farmakoterapie, kardiovaskulární nemoci--prevence a kontrola, kombinovaná farmakoterapie, monoklonální protilátky--aplikace a dávkování--terapeutické užití, serinové endopeptidasy, konvertasy proproteinů--antagonisté a inhibitory, and evolocumab
Language:
Czech and English
Description:
Projekt PROFICIO zahrnuje 20 klinických studií hodnotících účinek evolokumabu na výskyt kardiovaskulárních onemocnění včetně jeho bezpečnostního profilu a tolerance. Většina zařazených studií sleduje průměrné procentuální snížení koncentrací LDL-cholesterolu za 10 a 12 týdnů podávání evolokumabu ve srovnání se vstupními hodnotami. První výsledky byly prezentovány na přelomu srpna a září 2015 na kongresu Evropské kardiologické společnosti (ESC) v Londýně. Do této subanalýzy bylo zařazeno 3 146 pacientů, kteří absolvovali jednu z vybraných studií 3. fáze klinického zkoušení a kterým byl evolokumab podáván v dávce 140 mg s.c. 1krát za 2 týdny nebo 420 mg s.c. 1krát za 4 týdny. Hodnoty LDL-cholesterolu se po evolokumabu snížily v jednotlivých studiích o 56,5–74,9 % ve srovnání s placebem a o 36,9–44,9 % oproti ezetimibu. Výskyt nežádoucích účinků se nelišil od skupiny užívající placebo. Klíčová slova: evolokumab – projekt PROFICIO – LDL-cholesterol – kardiovaskulární riziko, The PROFICIO project includes 20 clinical studies evaluating the effect of evolocumab on the incidence of cardio­vascular disease including its safety profile and tolerance. Most of the included studies follow the average proportional decrease of LDL-cholesterol concentrations over 10 and 12 weeks of administering evolocumab as compared to the input values. The first results were announced at the congress of the European Society of Cardiology (ESC) in London at the end of August and beginning of September 2015. This subanalysis comprised 3146 patients, who underwent one of the selected studies of phase 3 clinical testing and who were administered a dose of 140 mg s.c. evolocumab once in 2 weeks, or 420 mg s.c. once in 4 weeks. LDL-cholesterol levels decreased after evolocumab by 56.5 – 74.9% in the individual studies as compared to placebo and by 36.9 – 44.9% compared to ezetimib. The incidence of adverse effects did not differ from the group which used placebo. Key words: evolocumab – PROFICIO project – LDL-cholesterol – cardiovascular risk, and Pavel Kraml
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

6309. Evoluce digitálních organismů v počítači

Creator:
Scholtz, Vladimír
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
fyzika, digitální evoluce, physics, digital evolution, 6, and 53
Language:
Czech
Description:
S myšlenkou vytvořit vlastní evoluci a její úspěšnou implementaci přišel Thomas Ray, biolog z Delawarské univerzity. Na počátku 90. let minulého století vytvořil systém zvaný Tierra (Země). Šlo o počítačový systém několika krátkých vzájemně si konkurujících programů. Programy se množily, v systému docházelo k mutacím a díky tomu k evoluci. V tomto systému Thomas Ray mj. pozoroval vznik parazitismu, kdy některé programy zkrátily svůj kód a k životu používaly kód programů jiných. Dalším významným systémem byla Avida, vyvinutá na Michigan State University, kde byl pozorován vznik složitých funkcí, a systém Amoeba, ve které byl pozorován vznik samoreplikujících struktur z náhodného počátečního kódu., The idea of creating an own self-evolution and its successful implementation came from Thomas Ray, a biologist at the University of Delaware, In the early 90s of the last century he created a computer system of short competing programs called Tierra (Earth) where programs reproduce and mutations occur. Thomas Ray observed the creation of parasitism, where some programs shorten their code length and the missing parts used from other programs. Another important system Avida was developed at Michigan State University, where the creation of new complex functions was observed and the system Amoeba, in which the emergence of self-replicating structures from random initial code was observed., Vladimír Scholtz., and Obsahuje seznam literatury
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

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