In this study we have evaluated the effect of maximal incremental cycling exercise (IE) on the systemic release of prostacyclin (PGI2), assessed as plasma 6-keto-PGF1α concentration in young healthy men. Eleven physically active - untrained men (mean ± S.D.) aged 22.7 ± 2.1 years; body mass 76.3 ± 9.1 kg; BMI 23.30 ± 2.18 kg · m-2; maximal oxygen uptake (VO2max) 46.5 ± 3.9 ml · kg-1 · min-1, performed an IE test until exhaustion. Plasma concentrations of 6-keto-PGF1α, lactate, and cytokines were measured in venous blood samples taken prior to the exercise and at the exhaustion. The net exercise-induced increase in 6-keto-PGF1α concentration, expressed as the difference between the end-exercise minus pre-exercise concentration positively correlated with VO2max (r=0.78, p=0.004) as well as with the net VO2 increase at exhaustion (r=0.81, p=0.003), but not with other respiratory, cardiac, metabolic or inflammatory parameters of the exercise (minute ventilation, heart rate, plasma lactate, IL-6 or TNF-α concentrations). The exercise-induced increase in 6-keto-PGF1α concentration was significantly higher (p=0.008) in a group of subjects (n=5) with the highest VO2max when compared to the group of subjects with the lowest VO2max, in which no increase in 6-keto-PGF1α concentration was found. In conclusion, we demonstrated, to our knowledge for the first time, that exercise-induced release of PGI2 in young healthy men correlates with VO2max, suggesting that vascular capacity to release PGI2 in response to physical exercise represents an important factor characterizing exercise tolerance. Moreover, we postulate that the impairment of exercise-induced release of PGI2 leads to the increased cardiovascular hazard of vigorous exercise., J. A. Zoladz ... [et al.]., and Obsahuje seznam literatury
We give existence theorems for weak and strong solutions with trichotomy of the nonlinear differential equation x(t)=L(t)x(t)+f(t,x(t)), t R where {L(t) in R}$ is a family of linear operators from a Banach space E into itself and f R E to E. By L(E) we denote the space of linear operators from E into itself. Furthermore, for a<b and d>0, we let C([-d,0],E) be the Banach space of continuous functions from [-d,0] into E and f^d [a,b] C([-d,0],E) E. Let L: [a,b] to L(E) be a strongly measurable and Bochner integrable operator on [a,b] and for t in [a,b] define tau_tx(s)=x(t+s) for each s in[-d,0]. We prove that, under certain conditions, the differential equation with delay x(t)=L(t)x(t)+f^d(t,tau_tx) if t in [a,b], Q has at least one weak solution and, under suitable assumptions, the differential equation (Q) has a solution. Next, under a generalization of the compactness assumptions, we show that the problem (Q) has a solution too., Adel Mahmoud Gomaa., and Seznam literatury