The tissue factor (TF) is one of the most important regulators of arterial thrombosis. Because arterial thrombosis is the pathophysiologic background of acute coronary syndrome, the possible impact of blocking the arterial thrombosis on its onset is a challenging problem. The investigations of TF brought a new concept of “cell-based coagulation model” which highlighted the question of blood-borne TF as a source of TF in circulating blood. In this review we summarize essential information on the pathophysiology, molecular structure, expression and distribution of TF and we propose a novel concept of blood-borne TF, suggesting the possibilities of inhibition of the coagulation cascade with newly synthetized drugs., M. A. Malý, P. Tomašov, P. Hájek, P. Blaško, I. Hrachovinová, P. Salaj, J. Veselka., and Obsahuje bibliografii a bibliografické odkazy
The aim of this study was to explore changes in plasma vascular endothelial growth factor (VEGF) in aged patients who undergone transcatheter aortic valve implantation or balloon angioplasty for the treatment of aortic stenosis. Plasma VEGF was measured in subjects with diabetes mellitus type 2 (DM) (n=21, age 79.2±1.6 years) and in non-diabetic subjects (non-DM) (n=23, age 84.4±0.7 years), using an ELISA kit. Before the procedure plasma levels of VEGF were significantly lower in DM than in non-DM patients (P<0.05). Plasma VEGF significantly increased in both groups (DM and non-DM) 24 h (387±64 vs. 440±30 pg/ml, P<0.05) and 72 h (323±69 vs. 489±47 pg/ml, P<0.05) after the endovascular procedure. However, the VEGF in DM patients was significantly lower compared to non-DM subjects up to one month after the endovascular procedure (283±47 vs. 386±38 pg/ml, P<0.05). We conclude that increased plasma VEGF in aged patients associates with atherosclerotic aortic valve stenosis. In spite of that plasma VEGF in DM was constantly significantly lower than in non diabetic patients, both before and after the endovascular procedure, possibly reflecting a disturbance of angiogenic/antiangiogenic balance in diabetes., V. Bláha, J. Šťásek, J. Bis, J. Fortunato, C. Andrýs, V. Pavlík, P. Polanský, M. Brtko, L. Sobotka., and Obsahuje bibliografii
Zpráva o konferenci, která se uskutečnila na Universitě v Birminghamu 6. - 8. ledna 2014., Miloš Zapletal., Rubrika: Konference, and Cizojazyčné resumé není.
We investigated the factors that impose an upper limit of salinity tolerance to the unicellular freshwater cyanobacterium Synechococcus sp. PCC 7942. Above approx. 0.4 M NaCl, Synechococcus cells cease to proliferate, after having accumulated 0.3 M sucrose. Cells that pre-accumulated sucrose could tolerate up to 0.5 M NaCl, but not 0.6 M NaCl. After exposure to 0.5 M NaCl or higher, the cells were irreversibly modified becoming unable for osmotic volume adjustments. and N. P. Ladas, G. C. Papageorgiou.
Double-regulated vertical axial water turbine with conical distributor, which is worldwide known as a Saxo-type turbine, is the main subject of this paper. Due to continuous research, development and improvement, advance and compact structure, simplified civil construction works, reliability, ecological design and versatile applicability, the turbine became very recognizable product of company Litostroj Power, with over 30 successfully commissioned units in North American and Canadian market mainly. Authors see the Saxo turbine as one of the most interesting and suitable solutions for small and medium size hydro power plants. This paper aims to draw attention on this unique and interesting turbine design especially because experiences show that hydro power plant investors are somehow conservative and they mainly prefer and trust in more conventional turbine types i.e. Kaplan turbines and tubular turbines. The paper enlightens important design, hydraulic, economic and operation advantages of the Saxo-type turbines and points out most obvious advantages comparing to tubular and Kaplan type turbines. As an evidence of safe and reliable operation, there is a special section at the end of the paper which is focused on field-feedback experiences obtained during exptensive turbine testing at commissioning tests, final field performance acceptance tests and operation experiences. and Obsahuje seznam literatury
The paper deals with mathematical modelling and computer simulation of the seismic response of chosen components of hte nuclear WWER 1999 reactor. The seismic response is investigated by numerical integration method in time domain. The seismic excitation is given by two horizontal and one vertical synthetic accelerograms at the level of the pressure vessel seating adjusted for a certain damping vallue 5 %. The main aim of the paper is seismic response assessment for two variants of nuclear fuel assemblies - VVANTAGE 6 and TVSA-T. The maximal values of displacements and linkages or component deformations are compared for both fuel assembly variants. and Obsahuje seznam literatury
To assess the short- and long-term impacts of UV radiation (UVR, 280-400 nm) on the microalga Scrippsiella trochoidea, we exposed cells to three different radiation treatments (PAB: 280-700 nm, PA: 320-700 nm, and P: 400-700 nm). A significant decrease in the photochemical efficiency (ΦPSII) at high irradiance (100% of incident solar radiation, 216.0 W m-2) was observed. Photoinhibition was reduced from 62.7 to 10.9% when the cells were placed in 12% solar radiation (26.1 W m-2). In long-term experiments (11 days) using batch cultures, cell densities during the first 5 days were decreased under treaments P, PA, and PAB, reflecting a change in the irradiance experienced in the laboratory to that of incident solar irradiance. Thereafter, specific growth rates increased and UV-induced photoinhibition decreased, indicating acclimation to solar UV. Cells were found to exhibit both higher ratios of repair to UV-related damage, shorter period for recovery and increased concentrations of UV-absorbing compounds (UVabc), whose maximum absorption was found to be at 336 nm. Our data indicate that S. trochoidea is sensitive to ultraviolet radiation, but was able to acclimate relatively rapidly (ca. 6 days) by synthesizing UVabc and by increasing the rates of repair processes of D1 protein in PSII. and W. C. Guan, S. H. Lu.
The skin matrix metalloproteinase 3, tissue inhibitors of matrix metalloproteinase 2 and collagen III content changes in type 1 diabetes and insulin resistance treated with insulin a nd metformin were studied. Healthy adult male Wistar rats were obtained from experimental animal house, Department of Experimental Pharmacology, Medical University in Bialystok. The rats were divided randomly into five groups of 8 rats each. Control rats were injected intraperitoneally by NaCl. Type IDDM was induced by a single injection of Streptozocin. Insulin resistance was induced by a high -fat diet. The chosen groups of rats were also treated with insulin or metformin. ELISA K its (USCN Life Science, China) were used to measure content of matrix metallo - proteinase 3 (ELISA Kit for Matrix Metalloproteinase 3 - MMP3), tissue inhibitor of matrix metalloproteinase 2 (ELISA Kit for Tissue Inhibitors of Metalloproteinase 2 - TIMP2) and content of collagen type 3 (ELISA Kit for Collagen Type III - COL3). The results were reported as a median. The statistical significance was defined as p<0.05. Type 1 diabetes and insulin resistance have significantly reduced the quality of the skin, shown by the increase in cont ent of matrix metalloproteinase 3 and the decrease in content of tissue inhibitors of matrix metalloproteinase 2. Type 1 diabetes and insulin resistance have reduced the quality of the skin expressed by type III collagen content decrease but for future studies it is recommend to determine rat interstitial collagenase, MMP -13, as well. Insulin and metformin treatment improved the quality of the diabetic skin, demonstrated by the type III collagen content increase., M. Knaś, K. Wołosik, A. Zalewska, A. Mikucka-Niczyporuk, I. Kasacka, M. Niczyporuk., and Obsahuje bibliografii
This article argues that it is central to consider the socialisation processes of migrant children in transnational settings when focusing on issues of integration and the transnationality of the next generation. A central experience of migrant children is that they grow up and are involved in both the emigration and immigration country (of their parents). Many of them circulate between Germany and Turkey several times and maintain multiple relationships across national borders when they are growing up. This has implications for their family relationships and educational careers in childhood, but beyond that it also has effects that are detectable into adulthood. The article shows that migrant children develop the potential and skills that enable them to live a transnational life. The question the article therefore addresses is whether and how a transnational childhood affects the transnationality and integration of the next generation in the adult life.
The paper deals with the experimental and numerical research of flows through prismatic turbine cascade in transonic regimes. The primary goal is to evaluate the influence of the non-uniformity of the inlet velocity profile to the span-wise distribution of energy losses. The numerical simulation with inlet velocity profile corresponding to the parameters of the flow in high speed wind tunnel in Nový Knín is compared with the experimental data. and Obsahuje seznam literatury