Hypoxia stimulates ventilation, but when it is sustained, a decline in the ventilatory response is seen. The mechanism responsible for this decline lies within the CNS, but still remains unknown. In this study, we attempted to elucidate the possible role of hypoxia-induced depression of respiratory neurons by comparing the ventilatory response to hypoxia in intact rats and those with denervated carotid bodies. A whole-body plethysmograph was used to measure tidal volume, frequency of breathing and minute ventilation (VE) in awake and anesthetized intact rats and rats after carotid body denervation during exposure to hypoxia (FIO2 0.1). Fifteen-minute hypoxia induced an initial increase of VE in intact rats (to 248 % of control ventilation in awake and to 227 % in anesthetized rats) followed by a consistent decline (to 207 % and 196 % of control VE, respectively). Rats with denervated carotid bodies responded with a smaller increase in VE (to 134 % in awake and 114 % in anesthetized animals), but without a secondary decline (145 % and 129 % of control VE in the 15th min of hypoxia). These results suggest that afferentation from the carotid bodies and/or the substantial increase in ventilation are crucial for the biphasicity of the ventilatory response to sustained hypoxia and that a central hypoxic depression cannot fully explain the secondary decline in VE., H. Maxová, M. Vízek., and Obsahuje bibliografii
Stať převážně empirického charakteru čerpá z archivních dat, ze zdrojů Centra pro výzkum veřejného mínění a z první fáze realizace projektu Grantové agentury ČR s názvem „Sociologický výzkum historického vědomí obyvatel České republiky”. Teoretická část textu vychází z konceptu kolektivní paměti, zejména z myšlenky selektivity a proměnlivosti obsahů uložených v paměti. Článek dále prezentuje kvantitativní data týkající se veřejného mínění o české historii a kvalitativní zjištění výzkumu o historickém vědomí získaná prostřednictvím metody focus groups., The article of a mostly empirical character is drawn from archive data, from the sources of the Centre for Public Opinion Research, and from the first phase of the undertaking of a project of the Grant Agency of the Czech Republic entit - led „The Sociological Research of the Historical Consciousness of Inhabitants of the Czech Republic“. The theoretical part of the text is based on the concept of collective memory, especially on the idea of the selectivity and changeability of contents saved in the memory. This article also presents quantitative data concerning the perspective held by public opinion on Czech history, and qualitative perspectives on historical consciousness attained through the use of focus groups., and Jiří Šubrt, Štěpánka Pfeiferová.
In this article the author deals with the essentiality of corruption.
This text is intended to be a contribution to the debate on the
definition of corruption and clientelism. The author focuses on distinction between public and private sphere and tries to explain why corruption and clientelism are phenomena related only to the public one. In the other words: why “bribery” within private sphere
(for example within interaction between two employees of two private companies) cannot be considered as corruption in its meaning used in social sciences.