The study focused on the factory colony of the mine „Jiří“ in Moravská Ostrava, by now only marginally reflected upon by the regional historians, does not aim to be a monograph dealing with the history of one of the rough number of 55 miners‘ colonies on the territory of contemporary Ostrava. The study of the colony of „Jiří“ that existed from the year 1872 or 1889 to the year 1970 was motivated, first, by the author’s interest in the proletarian colonies in Ostrava. But it also constitutes part of the research project begun in the year 2010. The research should culminate at producing a modern topography of miners‘ colonies of Ostrava that would replace the problematic topography of Jaroslav Bílek (1966). The study of the colony of „Jiří“ aims to refute the myth of its foundation before the year 1860, to describe in detail its constructional- architectonic development and the living standard, positively resolve the problem of the number of houses in the colony, and especially to remind the fact, unique in the region of Ostrava, of the double foundation of the colony in the years 1871 and 1888. Besides the general information concerning the setting and surroundings of the colony of „Jiří“ and its civic amenities, the study should provide the correction of the data on the population development of the colony in the years 1890–1910 presented in the thesis of Drahoslava Dušková (1976).
Metabolic syndrome is a prevalent, complex condition. The search for genetic determinants of the syndrome is currently undergoing a paradigm enhancement by adding systems genetics approaches to association studies. We summarize the current evidence on relations between an emergent new candidate, zinc finger and BTB domain containing 16 (ZBTB16) transcription factor and the major components constituting the metabolic syndrome. Information stemming from studies on experimental models with altered Zbtb16 expression clearly shows its effect on adipogenesis, cardiac hypertrophy and fibrosis, lipid levels and insulin sensitivity. Based on current evidence, we provide a network view of relations between ZBTB16 and hallmarks of metabolic syndrome in order to elucidate the potential functional links involving the ZBTB16 node. Many of the identified genes interconnecting ZBTB16 with all or most metabolic syndrome components are linked to immune function, inflammation or oxidative stress. In summary, ZBTB16 represents a promising pleiotropic candidate node for metabolic syndrome., O. Šeda, L. Šedová, J. Včelák, M. Vaňková, F. Liška, B. Bendlová., and Obsahuje bibliografii
The data derived from rat models and the preliminary results of human studies provide strong indices of involvement of common ZBTB16 variants in a range of cardiovascular and metabolic traits. This cross-sectional study in the Caucasian cohort of 1517 Czech adults aimed to verify the hypothesis that ZBTB16 gene variation directly affects obesity and serum lipid levels. Genotyping of nine polymorphisms of the ZBTB16 gene (rs11214863, rs593731, rs763857, rs2846027, rs681200, rs686989, rs661223, rs675044, rs567057) was performed. A multivariate bidirectional regression with the reduction of dimensionality (O2PLS model) revealed relationships between basal lipid levels and anthropometric parameters and some minor ZBTB16 alleles. In men, the predictors - age and presence of minor ZBTB16 alleles of rs686989, rs661223, rs675044, rs567057 - were associated with significantly higher body mass index, waist to hip ratio, body adiposity index, waist and abdominal circumferences, higher total cholesterol and LDL cholesterol and explained 20 % of variability of these variables. In women, the predictors - age and presence of the rs686989 minor T allele - were also associated with increased anthropometric parameters and total cholesterol and LDL cholesterol but the obtained O2PLS model explained only 7.8 % of the variability of the explained variables. Our study confirmed that the selected gene variants of the transcription factor ZBTB16 influence the obesity-related parameters and lipid levels. This effect was more pronounced in men., B. Bendlová, M. Vaňková, M. Hill, G. Vacínová, P. Lukášová, D. Vejražková, L. Šedová, O. Šeda, J. Včelák., and Obsahuje bibliografii