The aim of this study was to analyze the ECG time intervals in the course of the development of chronic anthracycline cardiomyopathy in rabbits. Furthermore, this approach was employed to study the effects of a model cardioprotective drug (dexrazoxane) and two novel iron chelating compounds - salicylaldehyde isonicotinoyl hydrazone (SIH) and pyridoxal 2-chlorobenzoyl hydrazone (o-108). Repeated daunorubicin administration induced a significant and progressive prolongation of the QRS complex commencing with the 8th week of administration. At the end of the study, we identified a significant correlation between QRS duration and the contractility index dP/dtmax (r=-0.81; P<0.001) as well as with the plasma concentrations of cardiac troponin T (r=0.78; P<0.001). In contrast, no alterations in ECG time intervals were revealed in the groups co-treated with either dexrazoxane or both novel cardioprotective drugs (SIH, o-108). Hence, in this study, the QRS duration is for the first time shown as a parameter suitable for the non-invasive evaluation of the anthracycline cardiotoxicity and cardioprotective effects of both well established and investigated drugs. Moreover, our results strongly suggest that novel iron chelators (SIH and o-108) merit further study as promising cardioprotective drugs against anthracycline cardiotoxicity., A. Potáčová, M. Adamcová, H. Čajnáková, L. Hrbatová, M. Štěrba, O. Popelová, T. Šimůnek, P. Poňka, V. Geršl., and Obsahuje bibliografii a bibliografické odkazy
Endothelium-protective properties of pharmacological agents may be assessed by using different experimental models of endothelial dysfunction or injury. The model of endothelial dysfunction induced by vessel perfusion with polymorphonuclear leukocytes (PMN) was used for evaluation of pentoxifylline (PTX) effects on vasoconstrictor responses to noradrenaline (NA) in the rabbit renal artery. Addition of PMN into the perfusion solution significantly increased the responses to NA at all doses. PTX administration (10-5 mol.l1) significantly diminished the constrictor responses to NA in vessels perfused with PMN+PTX when compared to the responses in PMN-perfused vessels (at dose 0.1 m g: 32.25 vs. 14.25, at dose 1 m g: 51 vs. 27.75 (p<0.01), at dose 10 m g 74.25 vs. 39.75 (p<0.05), all values expressed as median of perfusion pressure in mm Hg). The model of endothelial damage induced by repeated NA administration in 5 doses (10-50 m g of NA) was used for evaluation of the endothelium-protective effect of sulodexide (SLX). It was found that SLX (120 U/l) significantly decreased the number of desquamated endothelial cells (EC) compared to the control group (controls: 131.4± 20.1 EC, +SLX: 83.3± 13.8 EC, p<0.01). These results confirmed the favorable endothelium-protective effects of pentoxifylline and sulodexide in the two experimental models., V. Kristová, M. Kriška, P. Babál, M. N. Djibril, J. Slámová, A. Kurtanský., and Obsahuje bibliografii
Formulas for full seismic moment tensor composition are present, i.e. moment tensor is express as a function of ISO, CLVD, DC, strike, dip, rake, where ISO is amount of isotropic part, CLVD is amount of compensated liner-vector dipole and DC is amount of pure double couple. Two forms of final formulas are given: i, two matrixes multiplication, ii, extension of "classical" formulas for 6 independent moment tensor elements., Petr Kolář., and Obsahuje bibliografické odkazy
The paper presents the results of experimental examination of the weathering grade of granite rock mass in the medieval Jeroným Mine (Czech Republic). This mine is declared as a cultural heritage site of the Czech Republic therefore, non-destructive methods for determination of the Schmidt hammer rebound value and the ultrasonic pulse velocity were used to minimize negative impact on the historical workings during in situ exploration. Weathering grade of selected parts of the rockmass in underground spaces was classified visually according to the assumed classification (Hencher and Martin, 1982 in Vahed et al., 2009) and the above mentioned measurements were performed in these parts. Results show that the rebound value and the ultrasonic pulse velocity are decreasing with increasing weathering grade for all investigated parts. Therefore this result is possible to use as a supplementary method for evaluation of weathering grade of rock massif in this mine., Markéta Lednická and Zdeněk Kaláb., and Obsahuje bibliografické odkazy
About 75% of water for irrigation in Bangladesh comes from groundwater. As the crop yield is directly related to quality of water used for irrigation, an assessment of groundwater suitability for irrigation is essential for the growth of food production and poverty eradication. An attempt has been made in this paper to study the suitability of groundwater for irrigation in Bangladesh. Geographic information system (GIS) is used for the processing of groundwater quality data collected from 113 locations sporadically distributed over the country and the preparation of groundwater quality maps. The result shows that groundwater of the southwestern part of Bangladesh, which comprises 22.5% area of the country, is highly affected by salinity and sodium hazards. Groundwater in 10.54% area of the country is also contaminated by Arsenic above the permissible level recommended for irrigation. and Okolo 75 % vody pre závlahy v Bangladeši pochádza z podzemných vôd. Pretože úroda priamo závisí od kvality závlahovej vody, posúdenie vhodnosti vody pre závlahy je podstatné pre produkciu potravín a odstránenie chudoby. V štúdii je prezentovaný pokus o zhodnotenie vhodnosti podzemnej vody pre závlahy v Bangladeši. Na spracovanie údajov o kvalite podzemnej vody zo 113 lokalít rozmiestnených sporadicky po krajine a na prípravu máp kvality podzemnej vody sa použil geografický informačný systém (GIS). Výsledky naznačujú, že podzemná voda v juhozápadnej časti krajiny zaberajúcej 22,5 % jej plochy je silne ohrozená zasolenosťou a obsahom sodíka. Podzemná voda na ploche 10,54 % krajiny je tiež kontaminovaná obsahom arzénu nad prípustnú hranicu pre závlahovú vodu.
This study evaluated the subacute morphologic alterations in renal artery wall and renal nerves in response to catheter-based renal denervation (RDN) in sheep and also compared the efficiency of single-point and multiple-point ablation catheters. Effect of each ablation catheter approved for the clinical use (Symplicity FlexTM, Medtronic, Inc., or EnligHTNTM, St. Jude Medical, INC.) was compared to intact contralateral renal artery in 12 sheep by histopathology and immunohistochemistry evaluation after a 10-day period post-RDN procedure. The safety was verified by extensive evaluation of kidney morphology. Vascular wall lesions and nerve injuries were more pronounced in those animals treated with multi-point EnligHTN catheter when compared with animals treated with single-point Symplicity Flex catheter. However, neither RDN procedure led to complete renal nerve ablation. Both systems, tested in the present study, provided only incomplete renal nerve ablation in sheep. Moreover, no appreciable progression of the nerve disintegration in subacute phase post-RDN procedure was observed. This study further supports the notion that the effectiveness remains fully dependent on anatomical inter-individual variability of the sympathetic nerve plexus accompanying the renal artery. Therefore, new systems providing deeper penetrance to targeted perivascular structure would be more efficient.
The development of an elevation frame requires a movement model of the Earth's crust. Currently, regardless of the existence of ASG-EUPOS, it seems that the most reasonable approach is to use the model developed from the levelling data. In Poland three maps of vertical crustal movements were developed on the basis of levelling data. The most recent version was published in 2006. In the above mentioned elaborations, the vertical crustal movements were calculated from two subsequent first order levelling campaigns. The results of all four levelling campaigns in Poland were accumulated and digitalized to include more data. The colocation method was used to develop the model. The graphical representation was made with triangulation and linear interpolation. One unified database was developed on the basis of collected and unified data set of unadjusted observations. The first trials of common use of the three first order levelling campaigns were performed in 2008. However the available levelling data was not complete. The goal of this paper is to evaluate the usefulness of the data from the last three campaigns of precise levelling for the development of vertical movement model in Poland., Kamil Kowalczyk and Jacek Rapinski., and Obsahuje bibliografické odkazy
Ten light-harvesting complex (Lhc) proteins were investigated to determine which was the most appropriate protein marker of senescence in detached rice leaves. The levels of Lhc proteins were monitored by immunoblot analysis, which was conducted using commercially available antibodies raised against each Lhc protein. Among the Lhc proteins evaluated in this study, Lhca1, Lhcb1, Lhcb2, Lhcb3, and Lhcb5 were not appropriate to be used as senescence markers while others can be used after optimization of the procedure. and K. Kang ... [et al.].
Reliable observations are the prerequisite for high-precision GNSS data processing. Data quality evaluation at the pre-processing procedure can help the user to identify the weakness of the observations. The open source software package G-Nut/Anubis developed at Geodetic Observatory Pecny (GOP) is introduced and used for the evaluation of long-term BeiDou/GPS signal. Several key indicators are selected to evaluate the BeiDou/GPS observations. Quantitative analysis shows that more than 100 stations can achieve 6-hour standalone BeiDou positioning at least. The completeness of the BeiDou phase and code observations at three frequencies is higher than that of the GPS observations in the selected station which is mainly attributed to the high elevation observations from GEO and IGSO satellites. Qualitative analysis shows that the multipath effects for pseudorange observations are correlated with signal, receiver types and firmware versions besides the station environment. Users attempting to improve the pseudorange observations by multipath filter should pay attention also to the receiver-specific settings. Cycle slip counts are used to indicate the quality of carrier-phase observations. Results show that BeiDou C05 satellite is more affected by the cycle slips, in particular the third frequency observables. For GPS, the third frequency is more robust compared to the legacy frequencies. Comprehensive single point positioning results show that positioning accuracy for BeiDou is worse than that of GPS, which is mainly caused by less active satellites, worse geometry and the larger errors in the broadcast ephemeris. The BeiDou positioning accuracy was further degraded by the C13/C15 satellite and dominated by large clock errors. Broadcast evaluation shows that the BeiDou orbit errors are related to the constellations. Overall, the orbit precision for both GPS and BeiDou has been gradually improved. Outliers were observed for navigation records assigned with the healthy status, especially for BeiDou broadcast orbits. and Zhao Lewen, Dousa Jan, Vaclavovic Pavel, Ye Shirong, Xia Fengyu.
The observation network was built for the repeated determination of spatial position of points by means of the GPS method. It was built on the surface above extracted mining panels near Karviná, to monitor the development of subsidence depression in non-trivial geo-mechanical conditions. Two years of repeated surveying gave us the information about the process of creating of the subsidence depression in such area. The results gained so far show the important influence of the complicated tectonic situation on the behaviour of surface subsidence. A smooth development of subsidence depression without important irregularities was found out on sites without tectonic faults, while on sites where rock mass is disturbed with tectonic faults, the shape of subsidence depression is very irregular., Hana Doležalová, Vlastimil Kajzar, Kamil Souček and Lubomír Staš., and Obsahuje bibliografii