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1192. Algebraic integrability for minimum energy curves
- Creator:
- Yudin, Ivan and Silva Leite, Fátima
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- Darboux polynomials, drag power, Euler-Lagrange equations, grading, integrability, and vector fields
- Language:
- English
- Description:
- This paper deals with integrability issues of the Euler-Lagrange equations associated to a variational problem, where the energy function depends on acceleration and drag. Although the motivation came from applications to path planning of underwater robot manipulators, the approach is rather theoretical and the main difficulties result from the fact that the power needed to push an object through a fluid increases as the cube of its speed.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
1193. Algebras and spaces of dense constancies
- Creator:
- Bella, Angelo, Martinez, Jorge, and Woodward, Scott D.
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- space and algebra of dense constancy and $c$-spectrum
- Language:
- English
- Description:
- A DC-space (or space of dense constancies) is a Tychonoff space $X$ such that for each $f\in C(X)$ there is a family of open sets $\lbrace U_i\: i\in I\rbrace $, the union of which is dense in $X$, such that $f$, restricted to each $U_i$, is constant. A number of characterizations of DC-spaces are given, which lead to an algebraic generalization of the concept, which, in turn, permits analysis of DC-spaces in the language of archimedean $f$-algebras. One is led naturally to the notion of an almost DC-space (in which the densely constant functions are dense), and it is shown that all metrizable spaces have this property.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
1194. Alginate matrices for protein delivery: a short review
- Creator:
- Wawrzyńska, E and Dana Kubies
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- algináty, růstové faktory, alginates, growth factors, biomaterials, protein release, growth factor release, 14, and 612
- Language:
- English
- Description:
- Growth factors are powerful molecules that regulate cellular growth, proliferation, healing, and cellular differentiation. A delivery matrix that incorporates growth factors with high loading efficiencies, controls their release, and maintains bioactivity would be a powerful tool for regenerative medicine. Alginate has several unique properties that make it an excellent platform for the delivery of proteins. Mild gelling conditions can minimize the risk of protein denaturation; moreover, alginate can serve as protection from degradation until protein release. Various modifications have been proposed to tune alginate binding and release proteins, simultaneously adjusting alginate degradability, mechanical stiffness, swelling, gelation properties and cell affinity. The primary objective of this article is to review the literature related to recent advances in the application of alginate matrices in protein delivery in regenerative medicine. A special emphasis is put on the relevance of delivery of growth factors and chemokine., E. Wawrzyńska, D. Kubies., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
1195. Algoritmus operací mnohočetného myelomu a solitárního plazmocytomu páteře
- Creator:
- Hrabálek, Lumír, Wanek, Tomáš, Minařík, Jiří, Bačovský, Jaroslav, Ščudla, Vlastimil, and Vaverka, Miroslav
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, práce podpořená grantem, and TEXT
- Subject:
- algoritmy, mnohočetný myelom--diagnóza--chirurgie--patologie, plazmocytom--diagnóza--chirurgie--patologie, výsledky a postupy - zhodnocení (zdravotní péče), páteř--chirurgie--patologie, měření bolesti, neuralgie--chirurgie, přežití, dospělí, staří, ženské pohlaví, lidé, mužské pohlaví, and lidé středního věku
- Language:
- Czech and English
- Description:
- Mnohočetný myelom (MM) a solitární plazmocytom (SP) jsou nejčastější primární nádory páteře. Léčba MM a SP páteře je komplexní proces, který zahrnuje léčbu kauzální s cílem potlačit nádorový klon a dále léčbu podpůrnou, jejíž součástí je i chirurgická terapie. Operace přispívají k lepší kvalitě života a nabývají na významu a smysluplnosti zejm. díky zlepšené prognóze onemocnění. Navrhli jsme algoritmus operační léčby MM a SP a ten jsme dále prospektivně ověřovali a jeho vyhodnocení bylo cílem této studie. Pacienti byli operováni v průběhu 10 let, minimální doba sledování byl jeden rok. Soubor tvořilo 32 pacientů (20 mužů a 12 žen) s průměrným věkem 61 let. Operováno bylo celkem 61 obratlů. Důvodem k operaci byly projevy útlaku míchy a progredující neurologický deficit (hodnoceno Frankelovou škálou) nebo na konzervativní léčbu nereagující axiální bolest (hodnoceno VAS; Visual Analogue Scale) páteře. Provedena byla některá z těchto operací: vertebroplastika (VP), laminektomie, transpedikulární fixace, somatektomie a jejich kombinace, nebo okcipito‑cervikální fixace. Pooperační VAS a Frankelova škála byly vyhodnoceny za jeden rok, skiagramy a MR jsme provedli a zhodnotili každý jeden rok. U žádného pacienta nenastala lokální recidiva tumoru ani selhání stabilizace na operovaném úseku v celém sledovaném období. Průměrný předoperační VAS byl 6,8 a jeden rok po operaci se průměrný VAS snížil na 1,1. Všechny operační výkony vedly nejen ke kontrole bolesti, ale také k prevenci nebo zlepšení neurologického postižení po celou dobu sledování. Hodnotili jsme náš postup – algoritmus operací, míru radikality a jejich načasování jako optimální pro MM i SP., Multiple myeloma (MM) and solitary plasmacytoma (SP) are the most frequent primary tumors of the spine. Management of the spinal MM and SP is a complex process involving causal treatment to suppress the tumor clone, as well as supportive therapy, including surgery and radiotherapy. Surgery should be considered because of its favourable effect on disease prognosis. We proposed a surgical treatment algorithm in patients with spinal MM and SP and the aim of this article is to present prospective evaluation of this algorithm. Patients undergoing surgical treatment during the past 10 years were included in this study, with the minimum follow-up of one year. A total of 32 patients (20 males and 12 females) with the mean age of 61 years were included. Surgery of 61 vertebrae was performed. The procedures were indicated for progressing neurological deficit (Frankel score) and for axial spinal pain (VAS classification). We performed the following procedures: vertebroplasty, laminectomy, transpedicular fixation, somatectomy, and their combination, or occipito-cervical fixation. Frankel score and VAS was assessed one year after the surgery and X-ray and spinal MRI was performed every year. No local relapses of the tumor or stabilization failure were detected. The mean preoperative VAS was 6.8 and improved to 1.1 one year after the surgery. During the follow up period, we observed positive effect of surgery on pain control and on prevention or improvement of neurological dysfunction. The authors concluded that all surgical procedures, the extent of resection and timing were adequate in all subjects. Key words: multiple myeloma – solitary plasmacytoma –vertebroplasty – transpedicular fixation – somatectomy The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers., and L. Hrabálek, T. Wanek, J. Minařík, J. Bačovský, V. Ščudla, M. Vaverka
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
1196. Alien flora of Europe: species diversity, temporal trends, geographical patterns and research needs
- Creator:
- Lambdon, Philip W., Pyšek, Petr, Basnou, Corina, Hejda, Martin, Arianoutsou, Margarita, Essl, Franz, Jarošík, Vojtěch, Pergl, Jan, Winter, Marten, Anastasiu, Paulina, Andriopoulos, Pavlos, Bazos, Ioannis, Brundu, Giuseppe, Celesti-Grapow, Laura, Chassot, Philippe, Delipetrou, Pinelopi, Josefsson, Melanie, Kark, Salit, Klotz, Stefan, Kokkoris, Yannis, Kühn, Ingolf, Marchante, Hélia, Perglová, Irena, Pino, Joan, Vilà, Montserrat, Zikos, Andreas, Roy, David, and Hulme, Philip E.
- Type:
- article and TEXT
- Subject:
- alien plants, biogeographical pattern, donor regions, Europe, habitat affinity, naturalization, neophytes, plant invasions, residence time, and temporal trends
- Language:
- English
- Description:
- The paper provides the first estimate of the composition and structure of alien plants occurring in the wild in the European continent, based on the results of the DAISIE project (2004–2008), funded by the 6th Framework Programme of the European Union and aimed at “creating an inventory of invasive species that threaten European terrestrial, freshwater and marine environments”. The plant section of the DAISIE database is based on national checklists from 48 European countries/regions and Israel; for many of them the data were compiled during the project and for some countries DAISIE collected the first comprehensive checklists of alien species, based on primary data (e.g., Cyprus, Greece, F. Y. R. O. Macedonia, Slovenia, Ukraine). In total, the database contains records of 5789 alien plant species in Europe (including those native to a part of Europe but alien to another part), of which 2843 are alien to Europe (of extra-European origin). The research focus was on naturalized species; there are in total 3749 naturalized aliens in Europe, of which 1780 are alien to Europe. This represents a marked increase compared to 1568 alien species reported by a previous analysis of data in Flora Europaea (1964–1980). Casual aliens were marginally considered and are represented by 1507 species with European origins and 872 species whose native range falls outside Europe. The highest diversity of alien species is concentrated in industrialized countries with a tradition of good botanical recording or intensive recent research. The highest number of all alien species, regardless of status, is reported from Belgium (1969), the United Kingdom (1779) and Czech Republic (1378). The United Kingdom (857), Germany (450), Belgium (447) and Italy (440) are countries with the most naturalized neophytes. The number of naturalized neophytes in European countries is determined mainly by the interaction of temperature and precipitation; it increases with increasing precipitation but only in climatically warm and moderately warm regions. Of the nowadays naturalized neophytes alien to Europe, 50% arrived after 1899, 25% after 1962 and 10% after 1989. At present, approximately 6.2 new species, that are capable of naturalization, are arriving each year. Most alien species have relatively restricted European distributions; half of all naturalized species occur in four or fewer countries/regions, whereas 70% of non-naturalized species occur in only one region. Alien species are drawn from 213 families, dominated by large global plant families which have a weedy tendency and have undergone major radiations in temperate regions (Asteraceae, Poaceae, Rosaceae, Fabaceae, Brassicaceae). There are 1567 genera, which have alien members in European countries, the commonest being globally-diverse genera comprising mainly urban and agricultural weeds (e.g., Amaranthus, Chenopodium and Solanum) or cultivated for ornamental purposes (Cotoneaster, the genus richest in alien species). Only a few large genera which have successfully invaded (e.g., Oenothera, Oxalis, Panicum, Helianthus) are predominantly of non-European origin. Conyza canadensis, Helianthus tuberosus and Robinia pseudoacacia are most widely distributed alien species. Of all naturalized aliens present in Europe, 64.1% occur in industrial habitats and 58.5% on arable land and in parks and gardens. Grasslands and woodlands are also highly invaded, with 37.4 and 31.5%, respectively, of all naturalized aliens in Europe present in these habitats. Mires, bogs and fens are least invaded; only approximately 10% of aliens in Europe occur there. Intentional introductions to Europe (62.8% of the total number of naturalized aliens) prevail over unintentional (37.2%). Ornamental and horticultural introductions escaped from cultivation account for the highest number of species, 52.2% of the total. Among unintentional introductions, contaminants of seed, mineral materials and other commodities are responsible for 1091 alien species introductions to Europe (76.6% of all species introduced unintentionally) and 363 species are assumed to have arrived as stowaways (directly associated with human transport but arriving independently of commodity). Most aliens in Europe have a native range in the same continent (28.6% of all donor region records are from another part of Europe where the plant is native); in terms of species numbers the contribution of Europe as a region of origin is 53.2%. Considering aliens to Europe separately, 45.8% of species have their native distribution in North and South America, 45.9% in Asia, 20.7% in Africa and 5.3% in Australasia. Based on species composition, European alien flora can be classified into five major groups: (1) north-western, comprising Scandinavia and the UK; (2) west-central, extending from Belgium and the Netherlands to Germany and Switzerland; (3) Baltic, including only the former Soviet Baltic states; (4) east-central, comprizing the remainder of central and eastern Europe; (5) southern, covering the entire Mediterranean region. The clustering patterns cut across some European bioclimatic zones; cultural factors such as regional trade links and traditional local preferences for crop, forestry and ornamental species are also important by influencing the introduced species pool. Finally, the paper evaluates a state of the art in the field of plant invasions in Europe, points to research gaps and outlines avenues of further research towards documenting alien plant invasions in Europe. The data are of varying quality and need to be further assessed with respect to the invasion status and residence time of the species included. This concerns especially the naturalized/casual status; so far, this information is available comprehensively for only 19 countries/regions of the 49 considered. Collating an integrated database on the alien flora of Europe can form a principal contribution to developing a European-wide management strategy of alien species.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/
1197. Alien vascular plants recorded from the Barentsburg and Pyramiden settlements, Svalbard
- Creator:
- Liška , Jiří and Soldán , Zdeněk
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- adventive, allochtonous, Arctic, flora, introduced, non-indigenous, plant invasions, Spitsbergen, and Svalbard
- Language:
- English
- Description:
- A list of alien plant species recorded from Svalbard in the summer of 1988 is presented. Two localities, the Russian settlements of Barentsburg and Pyramiden on the Isfjorden, Spitsbergen, were studied. Prior to this study, almost 60 alien species were recorded from Svalbard by other investigators. During the research reported here, 44 taxa were found, 14 of which are new records for the Svalbard archipelago. Six species are considered to be possibly naturalized; however, it is difficult to assess their naturalization status because of the severity of the climate in the study area. A complete list of species is presented, with information on height and phenological stage of particular specimens. Most of the alien plants recorded at the two settlements belong to the family Brassicaceae.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
1198. ALKB-8, a 2-oxoglutarate-dependent dioxygenase and S-adenosine methionine-dependent methyltransferase modulates metabolic events linked to lysosome-related organelles and aging in C. elegans
- Creator:
- Kollárová, J., Kostrouchová, M., and Benda, A.
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- lysosome-related organelle, methyltransferase, multifunctional enzyme, Nile red, oxidoreductase, RNA-binding, and transferase
- Language:
- English
- Description:
- ALKB-8 is a 2-oxoglutarate-dependent di-oxygenase homologous to bacterial AlkB, which oxidatively demethylates DNA substrates. The mammalian AlkB family contains AlkB homologues denominated ALKBH1 to 8 and FTO. The C. elegans genome includes five AlkB-related genes, homologues of ALKBH1, 4, 6, 7, and 8, but lacks homologues of ALKBH2, 3, and 5 and FTO. ALKBH8 orthologues differ from other AlkB family members by possessing an additional methyltransferase module and an RNA binding N-terminal module. The ALKBH8 methyltransferase domain generates the wobble nucleoside 5-methoxycarbonylmethyluridine from its precursor 5-carboxymethyluridine and its (R)- and (S)-5-methoxycarbonylhydroxymethyluridine hydroxylated forms in tRNAArgUCG and tRNAGlyUCC. The ALKBH8/ALKB-8 methyltransferase domain is highly similar to yeast TRM9, which selectively modulates translation of mRNAs enriched with AGA and GAA codons under both normal and stress conditions. In this report, we studied the role of alkb-8 in C. elegans. We show that downregulation of alkb-8increases detection of lysosome-related organelles visualized by Nile red in vivo. Reversely, forced expression of alkb-8 strongly decreases the detection of this compartment. In addition, overexpression of alkb-8 applied in a pulse during the L1 larval stage increases the C. elegans lifespan. and Corresponding author: Marta Kostrouchová
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
1199. Alkohol a karcinom prsu – ekonomické náklady
- Creator:
- Šmídová, Iva
- Format:
- braille, text, and regular print
- Type:
- model:article, article, Text, přehledy, and TEXT
- Subject:
- lidé, ženské pohlaví, nádory prsu--ekonomika--terapie, zdravotní péče - náklady--statistika a číselné údaje, časové faktory, pití alkoholu--ekonomika--škodlivé účinky, staging nádorů--ekonomika, and ekonomika alkoholismu
- Language:
- Czech and English
- Description:
- Karcinom prsu je nejčastější nádorové onemocnění u žen. Každoročně postihuje více než 1 000 000 žen na celém světě. Z toho zhruba 11 % případů rakoviny prsu lze připisovat konzumaci alkoholu u žen. Cílem tohoto článku je vytvořit představu o podílu nákladů na léčbu karcinomu prsu, který lze přiřadit konzumaci alkoholu v ČR v roce 2007. Zjištěná výsledná částka, kterou je třeba vynaložit na léčbu pacientek pravidelně konzumujících alkohol, je 39 mil. Kč., Breast cancer is the most common cancer in women. Annually, it affects more than 1 million women worldwide. Thereof, some 11% of the breast cancer incidence can be attributed to alcohol consumption in women. The aim of this article is to create a notion of the proportion of the costs spent to treat breast cancer that can be ascribed to alcohol consumption in the Czech Republic in 2007. The overall amount that is to be spent to treat women patients who regularly consume alcohol is 39 million CZK., Iva Šmídová, and Literatura 20
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
1200. All graphs in which each pair of distinct vertices has exactly two common neighbors
- Creator:
- Stevanović, Dragan
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- graphs, adjacency matrix, eigenvalues of a graph, and common neighbours
- Language:
- English
- Description:
- We find all connected graphs in which any two distinct vertices have exactly two common neighbors, thus solving a problem by B. Zelinka.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public