The incidence of venous thromboembolism (VTE ) during childhood is low with two peaks – neonatal and adolescent age. This retrospective study is focused on clinical characteristics of VTE during adolescence. The main goals are to assess the most frequent inherited and acquired risk factors and to evaluate the benefit of D-dimers in diagnostics of venous thromboemblism. The data of 18 adolescents were analysed – 16 girls (88.9%), 2 boys (11.1%). In 9 patients (50%) thrombosis of the lower limb deep veins was diagnosed, six patients (33.3%) suffered from symptomatic pulmonary embolism (PE ) and 3 patients (16.7%) from thrombosis at unusual sites. One patient had an idiopathic VTE , the mean number of the inherited and acquired risk factors was 2.6. The most frequent inherited risk factor was Leiden mutation of factor V (27.8%). The most frequent acquired risk factor was oral contraception (OC ) in 12 out of 16 girls (75%). All of our patients on oral contraception had one or more additional risk factors. 10 out of 18 (55.6%) patients with VTE had elevated activity of factor VIII . The sensitivit, Aneta Samková, Kateřina Lejhancová, Jiří Hak, Antonín Lukeš, and Literatura 22
Chronic obstructive pulmonary disease (COPD) is a progressive and disabling disease that has been associated with aging. Several factors may potentially impair performance during exercise in elderly patients with COPD. This study was conducted to evaluate what characteristics related to lung function, peripheral muscle strength and endurance can predict the performance of elderly patients with COPD during cardiopulmonary exercise testing (CPET). Forty elderly patients with COPD underwent resting lung function tests, knee isokinetic dynamometry, and CPET. Three models were developed to explain the variability in peak oxygen uptake (VO2 peak) after controlling for age as an independent confounder. The pulmonary function model showed the highest explained variance (65.6 %); in this model, ventilation distribution (p<0.001) and pulmonary diffusion (0.013) were found to be independent predictors. Finally, the models that included the muscle strength and endurance variables presented explained variances of 51 % and 57.4 %, respectively. In these models that involved muscular dysfunction, however, only the endurance variables were found to be independent predictors (p<0.05). In conclusion, ventilation distribution and pulmonary diffusion, but not the degree of airway obstruction, independently predict CPET performance in elderly patients with COPD. In addition, peripheral muscle endurance, but not strength, also predicts CPET performance in these subjects.
Aims of the study were to compare the development of electrocardiographic responses of the ischemia-induced heterogeneities of activation and repolarization in the ventricular myocardium of normal and diabetic animals. Body surface ECGs and unipolar electrograms in 64 epicardial leads were recorded before and during 20 min after the ligation of the left anterior descending artery in diabetic (alloxan model, 4 weeks, n=8) and control (n=8) rabbits. Activation times (ATs), end of repolarization times (RTs) and repolarization durations (activation-recovery intervals, ARIs) were determined in ischemic and periischemic zones. In contrast to the controls, the diabetic rabbits demonstrated the significant prolongation of ATs and shortening of ARIs (P<0.05) during ischemia in the affected region resulting in the development and progressive increase of the ARI and RT gradients across the ischemic zone boundary. The alterations of global and local dispersions of the RTs in diabetics correlated with the Tpeak-Tend interval changes in the limb leads ECGs. In the ischemic conditions, the diabetic animals differed from the controls by the activation delay, significant repolarization duration shortening, and the increase of local repolarization dispersion; the latter could be assessed by the Tpeak-Tend interval measurements in the body surface ECGs., K. A. Sedova, M. A. Vaykshnorayte, A. O. Ovechkin, P. Kneppo, O. G. Bernikova, V. A. Vityazev, J. E. Azarov., and Obsahuje bibliografii
This work deals with the changes of rhetorical education and emotional orders in the second half of the 18th century. The aim of the research is to assess the relations among language education, funtions of medias, anthropological models and expression of emotions on the Threshold of enlightenment. The background of the research shapes the transformation of rhetorical tradition. The research of the broad field of pedagogical, rhetorical and moral discurs is focused on the collegium of Karl Heinrich Seibt., Václav Smyčka., and Obsahuje bibliografické odkazy
Článek se zabývá vývojem veřejného zdravotnictví jako oboru od jeho počátků koncem 18.století až po současnost. Jsou zmíněny některé důležité trendy a faktory, které teorii i praxi oboru ovlivnily, včetně zmínky o některých významných, našich i zahraničních protagonistech, kteří se o rozvoj veřejného zdravotnictví zasloužili. Je stručně zmíněn celoevropský kontext, s důrazem na skutečnosti, které současnou podobu veřejného zdravotnictví u nás nejvíce poznamenaly., The article is dealing with a development of the public health from its beginning at the end of the 18th century to the present. Some of the most important trends and factors influencing theory and practice of public health are briefly outlined. Some of the international and local protagonists which contributed the most are mentioned. Relevant European context of the public health development is also shortly discussed., Helena Hnilicová, and Lit.: 21
We verify functional a posteriori error estimate for obstacle problem proposed by Repin. Simplification into 1D allows for the construction of a nonlinear benchmark for which an exact solution of the obstacle problem can be derived. Quality of a numerical approximation obtained by the finite element method is compared with the exact solution and the error of approximation is bounded from above by a majorant error estimate. The sharpness of the majorant error estimate is discussed.
We verify functional a posteriori error estimates proposed by S. Repin for a class of obstacle problems in two space dimensions. New benchmarks with known analytical solution are constructed based on one dimensional benchmark introduced by P. Harasim and J. Valdman. Numerical approximation of the solution of the obstacle problem is obtained by the finite element method using bilinear elements on a rectangular mesh. Error of the approximation is measured by a functional majorant. The majorant value contains three unknown fields: a gradient field discretized by Raviart-Thomas elements, Lagrange multipliers field discretized by piecewise constant functions and a scalar parameter β. The minimization of the majorant value is realized by an alternate minimization algorithm, whose convergence is discussed. Numerical results validate two estimates, the energy estimate bounding the error of approximation in the energy norm by the difference of energies of discrete and exact solutions and the majorant estimate bounding the difference of energies of discrete and exact solutions by the value of the functional majorant.
This article offers a model, based on the physical conditions of articulation, for the relation between Sumerian and Akkadian stops. Other models can be discounted with a high probability. It is further argued, that the use of signs in older Akkadian should not be interpreted only from one of the two languages involved. From this point of view, a probably (if not fully provable) theory for the Akkadian š and its Sumerian counterparts is developed.