White adipose tissue (WAT) represents a reservoir of lipophilic environmental pollutants, especially of those which are resistant to biological and chemical degradation – so-called persistent organic pollutants (POPs). Large amounts of different congeners and isomers of these compounds exhibit a variety of adverse biological effects. Interactions among different classes of compounds, frequently with opposing effects, complicate hazard evaluation and risk assessment. WAT is the key organ for energy homeostasis and it also releases metabolites into the circulation and adipokines with systemic effects on insulin sensitivity and fuel partitioning in muscles and other tissues. Its beneficial role is lost in obesity when excessive accumulation of WAT contributes to severe diseases, such as diabetes. POPs may crossroad or modulate the effect of endogenous ligands of nuclear transcription factors, participating in differentiation, metabolism and the secretory function of adipocytes. These mechanisms include, most importantly: i) endocrine disrupting potency
of POPs ́ mixtures on androgen, estrogen or thyroid hormone metabolism/functions in WAT, ii) interference of dioxin-like chemicals with retinoic acid homeostasis, where impact on retinoid receptors is expected, and iii) interaction with transcriptional activity of peroxisome proliferator-activated receptors is likely. Thus, the accumulation and action of
POPs in WAT represents a unitary mechanism explaining, at least in part, the effects of POPs in the whole organism. By modulating WAT differentiation, metabolism and function, the POPs could affect not only the physiological role of WAT, but they may also influence the development of obesity-associated diseases.
Semi-dry grasslands in the White Carpathian (Bílé Karpaty) Mountains on the Czech-Slovak border are famous for their extremely high species richness. In places they contain more than 130 species of vascular plants per 100m2 and for some plot sizes they hold world records in the number of vascular plant species, but the reasons for this are poorly understood. Here we ask whether the high number of species in these grasslands can be explained by local ecological factors. We compared the White Carpathian grasslands with similar grasslands in adjacent areas in the west (southern Moravia) and the east (Inner Western Carpathians), which are on average notably poorer in species than those in the White Carpathians. In both of these areas, we sampled grasslands that were among the species richest in the regional context and had a similar physiognomy, species composition and ecology as those in the White Carpathians. We found 75 sites with >70 and >25 species of vascular plants per 100 m2 and 1 m2, respectively, in which we recorded species composition and local environmental conditions, including precipitation, soil depth, soil pH and nutrient concentrations, above-ground biomass production and nutrients in plant biomass. Although the White Carpathian grasslands were considerably richer in species than the richest grasslands in the adjacent regions, there were no differences in the values of the factors studied that could provide an unequivocal explanation of their high species richness. However, the values of the factors studied were within the ranges reported in the literature as conducive to high species richness in temperate grasslands. We conclude that the high species richness recorded in the White Carpathian grasslands cannot be explained by a single factor. It results from a unique combination of regional factors (long history of these grasslands, large size of individual grassland areas and their existence in a landscape mosaic with forests, scrub and small wetlands), local abiotic factors (soil pH, soil nutrient status, moisture regime and resulting grassland productivity that are suitable for many species from the regional species pool) and management (low fertilizer input and mowing once a year in late spring or summer).