Alterations in mitochondrial parameters are an important hallmark of Huntington’s disease (HD). The ubiquitous expression of mutant huntingtin raises the prospect that mitochondrial disturbances can also be detected and monitored through buccal epithelial cells. In a group of 34 patients with Huntington’s disease and a group of 22 age-related healthy volunteers, respiratory complex I and IV protein quantities in buccal epithelial cells were measured using the dipstick immunocapture assay. The protein quantity of respiratory complex I correlates with age (r = 0.427, P = 0.026, FWE-P = 0.156) in the patient group, but not in the group of healthy subjects. Our non-invasive approach allows us to obtain valuable information for the studies of mitochondrial biochemical parameters in patients with neurodegenerative diseases and could also be useful in epidemiological studies. and Corresponding author: Hana Hansíková
Buckling and postbuckling behaviour of a delaminated plate subjected to shear loading has been studied by means of the finite element analysis. The plate was assumed to contain either one or two circular delamintions of various diameteers and of various out-of-plane and in-plane positions. The size of the plate corresponded to the size of laminate panels used in aircraft structures. It was therefore possible to assess the practical applicability of numerous studies which focused on the buckling behaviour of substantially smaller plates. and Obsahuje seznam literatury