UVB radiation from sunlight induces an acute corneal inflammation, photokeratitis, accompanied by changes in corneal hydration. We employed a method of ultrasonic pachymetry for daily examination of central corneal thickness as an index of corneal hydration of the rabbit cornea repeatedly irradiated by UVB radiation (312 nm, daily dose of 0.25 J/cm2 during three or four days) as influenced by UVB absorber (actinoquinol combined with hyaluronic acid) dropped on the ocular surface during irradiation. One day after the third irradiation procedure the animals were sacrificed and corneas examined immunohistochemically for peroxynitrite formation, a marker of oxidative damage, the antioxidant aldehyde dehydrogenase 3A1 and endothelial nitric oxide synthase, an enzyme generated nitric oxide. Results show that UV absorber combined with hyaluronic acid protected the cornea against UVB-induced changes in corneal thickness and microscopical disturbances to the cornea (both seen after buffered saline application) until the fourth experimental day. These UVB doses are equivalent to a daily exposure of 2.5 hrs of the human cornea to solar UVB radiation for three consecutive days. It is suggested that actinoquinol/ hyaluronic acid drops might be helpful for the human eye in the defence against photooxidative and other oxidative processes. and Obsahuje seznam literatury
The author summarizes the life and in particular scientifi c career of historian Bedřich Loewenstein, describes areas of his professional interest and his intellectual orientation, reminds of his most important works published in Czech and German, and assesses his contribution. Loewenstein was born in 1929 in Prague, in a Czech- -German-Jewish family, lived through the German occupation in diffi cult conditions, and started studying history and philosophy at what was then the Faculty of Arts and History of the Charles University, but was expelled two years later for political reasons. He was allowed to complete his studies later, and in 1957 started working at the Institute of History of the Czechoslovak Academy of Sciences, where he remained until his dismissal in 1970. He started intensive contacts with West German historians and other intellectuals during the 1960s, and organized an important international symposium, ''Europe and Fascism'', in Prague in 1969. Since the early 1970s, he was not allowed to publish and was employed as an interpreter/translator of the trade mission (since 1973 embassy) of the Federal Republic of Germany. Although watched by the State Security, he managed to make use of his position to establish an important connection between domestic dissenters and their supporters abroad, which was used to exchange publications and other documents. In 1979, he accepted an offer of professorship of recent history at the Free University in West Berlin, where he remained until 1994 and where he could develop and expand his research interests and devote himself to intensive publication activities. For a long time, Bedřich Loewenstein was focusing on the German history of the 19th and 20th centuries; since the 1960s, he was also studying ideological, psychological, and social prerequisites of Nazism and later also more general issues of crises of the 20th century, modernism and modernity, civic society, European nationalism, and civilization. In this respect, he was able to integrate approaches and knowledge of other social sciences - sociology, social psychology, anthropology, philosophy, political science, and economy - in a prolifi c manner. He was a long-time and intensive intermediary of views and ideas between the Czech (or Czechoslovak) and German historiographies. His works, written in a concise, scientifi c-essayist style, earned him respect among colleagues both at home and abroad. His principal works include Plädoyer für die Zivilisation (Hamburg, Hoffmann und Campe 1973), Entwurf der Moderne: Vom Geist der bürgerlichen Gesellschaft und Zivilisation (Essen, Reimar Hobbing 1987; in Czech in 1995), Problemfelder der Moderne: Elemente der politischen Kultur (Darmstadt, Wissenschaftliche Buchgesellschaft 1990), My a ti druzí: Dějiny, psychologie, antropologie [We and the others: History, psychology, anthropology] (Brno, Doplněk 1997; in German in 2003). A synthesis of Loewensteinʼs thinking about a broad spectrum of issues is presented in his book Der Fortschrittsglaube: Geschichte einer europäischen Idee (Göttingen,Vandenhoeck & Ruprecht 2008; in Czech: Víra v pokrok: Dějiny jedné evropské ideje [Faith in progress: The history of a European idea]. Praha, OIKOYMENH 2009). and Překlad: Jiří Mareš