Search

Start Over Original context has metadata only false

1035. (Copernican) Experiences and the (Copernican) Bible in Galileo’s Letter to Castelli

Creator:
Vesel, Matjaž
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
teorie vědy, theory of science, Galileo, dopis Castellimu, heliocentrismus, biblická hermeneutika, zkoumání přírody, Letter to Castelli, heliocentrism, Biblical hermeneutics, natural investigation, 12, and 00
Language:
Czech
Description:
Článek se zaměřuje na Galileův Dopis Castellimu z  21.  prosince 1613. Autor analyzuje Galileovy hermeneutické principy představené v první části dopisu (bible by měla být vyloučena ze zkoumání přírody) a jeho doslovnou interpretaci pasáže z  knihy Jozue (10: 12–13), v  duchu kopernikanismu, která se objevuje ve druhé části dopisu. Zdá se, že Galileo užívá bibli jako vědeckou autoritu a  na  podporu svých kopernikánských názorů, a  tak se ocitá v  rozporu se svými vlastními hermeneutickými principy. Autor tvrdí, že Galileovo stanovisko je konzistentní, zvláště pokud se vezme v  úvahu historický kontext jeho vzniku, tj. kontext stálých, teologicky motivovaných útoků na  Koperníka, Galilea a  jeho věrnost heliocentrickému systému světa (pohyb Země odporuje bibli) a  kontext jeho nedávných teleskopických pozorování a objevů., The article focuses on Galileo’s Letter to Castelli, 21 December 1613. The author analyzes Galileo’s hermeneutical principles established in the first part of the letter (the Bible should be excluded from natural investigation) and his literal interpretation of the passage from the Book of Joshua 10, 12–13, in Copernican terms, in the second part of the letter. Galileo appears to use the Bible as a scientific authority, supporting his Copernican views, and thus he seems to contradict his own hermeneutical principles. The author argues that Galileo’s position is consistent, especially if one takes into account the historical context of its genesis, that is, in the context of the constant, theologically-inspired attacks on Copernicus and Galileo and his commitment to the heliocentric world system (the movement of the earth contradicts the Bible) and in the context of his newly-made telescopic observations and discoveries., and Matjaž Vesel.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

1036. (E)straperlo: začiatok konca Druhej španielskej republiky? :

Creator:
Timko, Maroš
Type:
text and studie
Subject:
Dějiny států a území na Pyrenejském poloostrově, aféry politické, korupce, politici španělští, Španělsko, světové dějiny 1918-1945, and vnitřní politika
Language:
Slovak
Description:
(E)straperlo: the beginning of the end of the Second Spanish Republic? The example of the political corruption and comparison of the reflection on crisis in Madrid and Asturias.
Rights:
unknown

1037. (Far) Outside the box: Genomic approach to acute porphyria

Creator:
Thunell, S.
Type:
article, model:article, and TEXT
Subject:
Acute porphyria, Acute attack, ALAS1, Caffeine, CAR, Fasting, FOXO, Ghrelin GR, HCC, HPA-axis, HNF4, Infection, Inflammation, Leptin, Nicotine, PGC1 alpha, Review, Stress, Steroid, Smoking, STAT5, Pathophysiology, PXR, Sex hormone, Steroids, Transactivation, and Trauma
Language:
English
Description:
The question of the reasons for the extreme variation in morbidity among the gene carriers of acute porphyria and the great diversity of the precipitating factors are approached by the aid of a model of interacting genomic circuits. It is based on the current paradigm of the acute porphyric attack as a result of a toxic proximal overload of the enzyme- deficient heme-biosynthetic patway. Porphyrogenic influx of precursors is seen as a consequence of uncontrolled induction of its gate-keeping enzyme, ubiquitous 5-aminolevulinate synthase (ALAS1), due to attenuated post-translational control of the enzyme combined with activated gene transcription. Focus is directed on the genomic control of the master-regulator of ALAS1-transcription, the nuclear receptor pair constitutively active receptor (CAR) and pregnane xenobiotic receptor (PXR). On activation by their ligands, i.e. lipophilic drugs, solvents, alcohols, hormonal steroids and biocides, these DNA-binding proteins transform xenobiotic or steroid stimuli to coordinated activations of gene transcription-programs for ALAS1 and apo-cytochromes P450 (apo-CYPs), thus effecting the formation of xenobiotic-metabolizing cytochrome P450 enzymes. The potency of the CAR/PXR-transduction axis is enhanced by co-activators generated in at least four other genomic circuits, each triggered by different external and internal stimuli clinically experienced to be porphyroge nic, and each controlled by co-activating and co-repressing modulators. The expressions of the genes for CAR and PXR are thus augmented by binding glucocorticoid receptor (GR) activated by a steroid hormone, e.g, cortisol generated in fasting, infection or different forms of stress. The promotor regions of ALAS1 and apoCYPs contain binding sites for at least three co-activating transcription factors enhancing CAR/PXR transduction: i.e. the ligand-independent growth hormone (GH)-pulse controlled hepatocyte nuclear factor 4 (HNF4), the insulin-responsive forkhead box class O-(FOXO) protein pathway activated in stress and infection, and the proliferator-activated receptor gamma co-activator 1 al pha (PGC-1alpha) circuit responding to glucagon liberated in fasting. Many interactions and cross-talk take place within the tangle of genomic circuits that control ALAS1-transcription, which may explain the extreme inter- and intra-individual variability in morbidity in acute porphyria. Reasons for gender-differences are found in sex-dependent control of HPA- and GH-activity as well as in direct, or GR-mediated effects on CAR/PCR activation. Constitutional differences in individual porphyric morbidity may be discussed along lines of mutations or duplications of genes for co-activating or co-repressing nuclear proteins active at different levels within the circuits.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

1038. (In)Visible women in political life in Slovakia

Creator:
Bitušíková, Alexandra
Format:
print
Type:
model:internalpart and TEXT
Language:
Czech
Description:
The article deals with the questions of the (in)visibility of women in Slovak political life. The material presents statistical data on women's participation in Slovak national, regional and local politics with the support of qualitative data from interviews with women politicians and activists. The author looks at the reasons for the low political representation of women and the unsuccessful attempts to increase it by introducing positive mechanisms such as quotas. The primary focus is put on the representation of women in municipal politics. The author analyses the main reasons why women are more successful in local politics than in 'high' politics.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

1040. (M)any Questions?: a comparison of the use of questions in Wittgenstein’s first 37 paragraphs of philosophical investigations with Austin’s essay ''The meaning of a word''

Creator:
Fajmon, Blahoslav
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
academic, Austin, pedagogical, philosophical investigations, philosophy, questions, response, stylistic, ''The meaning of a word'', typology, Wittgenstein, and writing style
Language:
Slovak
Description:
Wittgenstein’s approach to philosophy is closely related not only to the content but also to the form of his investigations. The following paper presents the uniqueness of Wittgenstein’s writing style, namely his use of questions, by comparing part of his work with Austin’s essay. For this purpose a typology of questions with regard to their function in the text is established and applied. The difference between Wittgenstein’s and Austin’s writing style is then documented by the frequency of certain types of questions, and omission of others, and related to some of Wittgenstein’s remarks about his approach to philosophical inquiry. The difference is then summarized tentatively as one between ''pedagogical'' and ''academic'' writing style, which poses questions concerning the translation of Wittgenstein’s investigations into academic prose., Wittgensteinův přístup k filozofii úzce souvisí nejen s obsahem, ale také s formou jeho vyšetřování. Následující článek prezentuje jedinečnost Wittgensteinova stylu psaní, konkrétně jeho použití otázek, porovnáním části jeho práce s Austinovým esejem. Pro tento účel je zavedena a aplikována typologie otázek s ohledem na jejich funkci v textu. Rozdíl mezi Wittgensteinovým a Austinovým stylem psaní je pak dokumentován četností určitých typů otázek a opomenutím druhých a je spojen s některými Wittgensteinovými poznámkami o jeho přístupu k filosofickému zkoumání. Rozdíl je pak předběžně shrnut jako ,,pedagogický'' a ,,akademický'' styl psaní, který představuje otázky týkající se překladu Wittgensteinových výzkumů do akademické prózy., and Blahoslav Fajmon
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

Limit your search

Show values starting with
more »

Show values starting with
more »

Show values starting with
more »

Show values starting with
more »

Show values starting with
more »

Show values starting with
more »

Show values starting with
more »

Show values starting with
more »

Show values starting with
more »

View distribution

Current results range from 0 to 2024

View larger »