Chronic allograft nephropathy (CAN) represents a frequent and irreversible cause of long-term renal graft loss. TGF- β 1 is a key profibrogenic cytokine associated with CAN pathogenesis. Because of clinical diagnostic inaccuracy, protocol biopsy has been suggested to be a beneficial method for early CAN detection. Protocol core biopsy was carried out in 67 consecutive cyclosporine-based immunosuppression-treated kidney transplant recipients with stable renal function 12 months after renal transplantation. Biopsy specimens were analyzed morphologically according to Banff-97' criteria and immunohistologically for TGF- β 1 staining. The data obtained were correlated with plasma TGF- β 1 levels and clinical data. CAN (grade I-III) was found in 51 patients (76 %). CAN grade I was found to be the most frequent one (44 %). A normal finding within the graft was made in only 12 patients (18 %). Clinically silent acute rejection Banff IA was present in 4 patients (6 %). In 8 patients (12 %) with CAN, borderline changes were present. We found a significant correlation between CAN grade and creatinine clearance, as measured by the Cockroft-Gault formula (p<0.01) as well as body mass index (p<0.01). There was a significant correlation between chronic vasculopathy (Banff cv) and creatinine clearance, and between the degree of TGF- β 1 staining and chronic vasculopathy (p<0.01). There were no relations between morphological findings and TGF- β 1 plasma levels, cyclosporine levels, plasma lipids, HLA- mismatches, panel reactive antibodies (PRA), proteinuria, and the donor's age. In conclusion, CAN is a frequent finding in protocol kidney graft biopsies 12 months after transplantation. TGF- β 1 tissue expression is linked with chronic vasculopathy., O. Viklický, I. Matl, L. Voska, R. Böhmová, M. Jarešová, J. Lácha, A. Lodererová, I. Stříž, V. Teplan, Š. Vítko., and Obsahuje bibliografii
The aim of this article is to sketch a certain method of indirect reconstruction of the process by which mathematics as a deductive discipline emerged in ancient Greece. We try out this method in a reconstruction of Thales' mathematics, but the main aim for which this method has been developed is the work of Pythagoras. We consider the process of the emergence of mathematics as a process of the constitution of a new language in the framework of which one can carry out deductive proofs. Therefore we base the method of indirect reconstruction of the emergence of mathematics on the theoretical findings in the book L. Kvasz: Vedecká revolúcia ako lingvistická událosť (The Scientific Revolution as a linguistic event, Prague, Filosofia 2013)., Ladislav Kvasz., and Obsahuje poznámky a bibliografii
Studie se zabývá částečným objevem hudebního rukopisu Thannenwald z polského přístavního města Elblag nedaleko Gdaňsku, který vznikl kolem roku 1600., Agnieszka Leszczyńska., Rubrika: Studie, and České resumé na s. 114, anglický abstrakt na s. 105
Královská kanonie premonstrátů na Strahově - Strahovská knihovna Praha CZ BU II 113 adl. 22, Knihovna Akademie věd ČR Praha CZ TF 347 adl. 21, Národní knihovna ČR Praha CZ 65 E 3062, Národní knihovna ČR Praha CZ 46 B 183 adl. 2, Národní knihovna ČR Praha CZ 46 F 74 adl. 26, Klášter Rytířského řádu křižovníků s červenou hvězdou - knihovna Praha CZ XVI H 8 adl. 8, Klášter Rytířského řádu křižovníků s červenou hvězdou - knihovna Praha CZ XVIII K 4 adl. 14, Metropolitní kapitula u sv. Víta v Praze Praha CZ I. b. 41 adl. 3, Metropolitní kapitula u sv. Víta v Praze Praha CZ C. d. beta 45 adl. 32, and BCBT40371