Autoimmune thyroiditis (AIT) and type 2 diabetes mellitus (DM2) are the most common endocrinological diseases worldwide. Relation between these diseases explains several hypotheses. One of them is influence of some adipocytokines. This study evaluated association between three adipocytokines (adiponectin, resistin and visfatin) and thyroid and glycid status in patients with DM2 and AIT compared to the control group (CG). The group consisted of four subgroups: patients with DM2 without thyreopathies, patients with AIT on substitution therapy without diabetes and prediabetes, patients with DM2 and AIT on substitution therapy and healthy subjects as the CG. We investigated parameters of thyroid and glucose metabolism and serum levels of three adipocytokines. The mean level of resistin in the group of patients with diabetes and thyroiditis was significantly higher than in patients with thyroiditis without diabetes and than in the CG. We found a weak negative correlation between visfatin and fasting glucose levels in patients with thyroiditis without diabetes. We detected a weak negative correlation between resistin and glycated hemoglobin and a weak negative correlation between visfatin and thyroid gland volume in patients with diabetes without thyroiditis. In the CG we determined a weak positive correlation between visfatin and free thyroxin. Our results are consistent with several studies, which confirmed association between AIT and adipocytokines.
We investigated the association between metamphetamine dependence and TaqI A polymorphism of the dopamine receptor D2 gene (DRD2), I/D polymorphism in angiotensin-converting enzyme (ACE) and M235T polymorphism of the angiotensinogen gene (AGT) in 93 unrelated metamphetamine-dependent subjects and 131 controls. Our results did not prove any association of TaqI A polymorphism of the DRD2 gene, I/D polymorphism of ACE gene, and M235T polymorphism of AGT gene with the metamphetamine dependence in Caucasians of Czech origin. However, a significant difference in allele I frequency between male and female control groups for the I/D ACE polymorphism (p<0.03) was found., O. Šerý, V. Vojtová, P. Zvolský., and Obsahuje bibliografii
Bradykinin can enhance skeletal muscle glucose uptake (GU), and exercise increases both br adykinin production and muscle insulin sensitivity, but bradykinin’s relationship with post-exercise insulin action is uncertain. Our primary aim was to determine if the B2 receptor of bradykinin (B2R) is essential for the post- exercise increase in GU by insulin-stimulated mouse soleus muscles. Wildtype (WT) and B2 R knockout (B2RKO) mice were sedentary or performed 60 minutes of treadmill exercise. Isolated soleus muscles were incubated with [ 3 H]-2-deoxyglucose ±insulin (60 or 100 μ U/ml). GU tended to be greater for WT vs. B2RKO soleus with 60 μ U/ml insulin (P=0.166) and was significantly greater for muscles with 100 μ U/ml insulin (P<0.05). Both genotypes had significant exercise-induced reductions (P<0.05) in glycemia and insulinemia, and the decrements for glucose (~14 %) and insulin (~55 %) were similar between genotypes. GU tended to be greater for exercised vs. sedentary soleus with 60 μ U/ml insulin (P=0.063) and wa s significantly greater for muscles with 100 μ U/ml insulin (P<0.05). There were no significant interactions between genotype and exercise for blood glucose, plasma insulin or GU. These results indicate that the B2R is not essential for the exerci se-induced decrements in blood glucose or plasma insulin or for the post-exercise increase in GU by insulin-stimulated mouse soleus muscle., G. G. Schweitzer ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
In this study, the 2n = 58 chromosomal race of blind mole rats,
Nannospalax xanthodon, from the Erzincan province in Turkey was investigated. Conventional chromosome staining, Ag-NOR staining and C-banding analysis were carried out in the specimens studied. The karyotype included three small or medium-sized meta/submetacentric pairs and twenty-five acrocentric pairs of autosomes of gradually diminishing size (NFa = 62). C-heterochromatin regions were found in centromeric and pericentromeric areas or in short arms of some bi-armed autosomal pairs and in pericentromeric areas of a few acrocentric autosomes. The X chromosome had a centromeric C-positive band and the short arm of the Y chromosome appeared to be C-positively stained. The NORs were
localized in distal heterochromatin areas of the short arms of two pairs of biarmed and one pair of acrocentric autosomes. Within the 58 chromosome populations reported from Turkey, two groups can be recognized differing by the presence or absence of a large submetacentric autosomal pair. The populations possessing this marker chromosome occur in central and northern Anatolia, whereas populations form eastern Anatolia have no similar chromosome in their karyotype.
Field observations in the northwest of Naein (Central Iran zone) indicate various types of alteration products have extended into pyroclastic and volcanic units with Oligo- miocene age. It seems the Zefreh (with NW- SE trend) and Kachumesqal (with E-W trend) faults are effective factors in the formation of Neysian and Barzavand copper deposits respectively. Alteration in Barzavand copper deposit (with stratabound form) includes pyritization, propylitization, zeolitization, saussuritization, uralitization and silicification, while in Neysian (with oval form) include phyllic, advanced argillic, argillic and propylitic. Geochemical studies in Barzavand show the positive correlation between (La/Lu)N, (La/Yb)N and (La/Sm)N and CaO (r= 0.70 to 0.96) related to propylitization of host rock basalt and increase in pH of fluids responsible for mineralization that play important role in differentiation of lanthanides in study area. The Barzavand copper deposit has submarine volcanism, diagenesis, burial metamorphism and weathering stages during its evolution. Remarkable geochemical features in Neysian include high (La/Lu)N, Ba and Sr values than La, Ce and Y. It seems that extensive alteration occurred along with hypogene and supergene processes in Neysian. According to alteration properties, mineralogy and the whole-rock geochemistry, the Barzavand and Neysian copper deposits are most similar to Manto- type and porphyry copper deposits respectively.
The bathymetric range of 149 digenean species recorded deeper than 200 m, the approximate depth of the continental shelf/slope break, are presented in graphical form. It is found that only representatives of the four families Lepocreadiidae, Fellodistomidae, Derogenidae and Hemiuridae reach to abyssal regions (>4,000 m). Three other families, the Lecithasteridae, Zoogonidae and Opecoelidae, have truly deep-water forms reaching deeper than 3,000 m. Bathymetric data are available for the Acanthocolpidae, Accacoeliidae, Bucephalidae, Cryptogonimidae, Faustulidae, Gorgoderidae, Monorchiidae and Sanguinicolidae showing that they reach deeper than 200 m. No bathymetric data are available for the members of the Bivesiculidae and Hirudinellidae which are reported from deep-sea hosts. These results indicate that only seventeen out of the 150 or so digenean families are reported in the deep sea.
Příspěvek Jana Bati je zprávou o mezinárodní muzikologické konferenci, která se uskutečnila v chorvatském Dubrovníku ve dnech 26. až 28. března 2012., Jan Baťa., Rubrika: Konference, and Cizojazyčné resumé není.
The paper deals with a special way of the construction of the boundary conditions for the compressible gas flow. The solution of the Riemann problem is used at the boundary. It can be shown, that the unknown one-side initial condition for this problem can be partially replaced by the suitable complementary condition. Authors work with such complementary conditions (by the preference of pressure, velocity, total quantities,...) in order to match the physically relevant data. Algorithms were coded and used within the own developed code for the solution of the Euler, NS, and the RANS equations, using the finite volume method. Numerical example shows superior behavior of these boundary conitions in comparison with some other boundary conditions. and Obsahuje seznam literatury