This catalogue is computer-based and issued in collaboration with the CDS in Strasbourg. The outlay of the catalogue will be described, particularly the tracer system for data base handling. A new examination of cluster appearances on survey charts has been entered in the 1983 edition. Various parameters will be compared and their accuracy discussed.
We have evaluated whether the addition of either bradykinin or histamine favours the lymphatic absorption of human recombinant ¡nterferon-a2 (IFN-cq) administered by the subcutaneous route. Subcutaneous administration of IFN-a2 with bradykinin enhances IFN absorption via both capillaries and lymphatics, so that either the plasma or lymph areas under the concentration curves (ACJC) increase significantly up to 1751 ±483 and 1319±608 l(_l/ml/min respectively as compared to the respective ACJC values (613±208 and 483±213 ICJ/ml/min) obtained after IFN injection in normal saline. Since the lymph ACJC/plasma ACJC ratios remain unaltered, there is no preferential lymphatic absorption of IFN-a2 after bradykinin administration. Dual-label experiments, 125l-IFN-a2 in saline and 131l-IFN-a2 in saline containing 200 jig histamine were injected subcutaneously into the left and into the right shank of the same animal, gave similar results. The kinetics of 125l and 131l acid-soluble radioactivity confirm that histamine favours both plasmatic and lymphatic absorption.
Sequencing of SSU rDNA showed that actinospores of the tetractinomyxon type, which develop in Chone infundibuliformis Krøyer (Annelida, Polychaeta, Sabellidae) from the northern Øresund, Denmark, are identical with Ceratomyxa auerbachi Kabata, 1962 (Myxozoa, Ceratomyxidae). This myxosporean was found in the gallbladder of the Atlantic herring Clupea harengus L. from the northern Øresund, Denmark, and from the Bergen area, western Norway. The pansporocysts and actinospores of C. auerbachi are described. This is the third elucidated two-host life cycle of a marine myxozoan, and the first involving a marine ceratomyxid.
The article presents the mathematical model non-homogenous, isotropic environment, where is possible to create various types of flows (the chemical reaction flow, the diffusion flow, the heat flow, the electromagnetic flow). and Obsahuje seznam literatury
The paper presents a method of experimental and model investigations, enabling the monitoring of rehabilitation process, for parents with upper limbs diseases, having neurological base. The changes of forces, generated by particular groups of upper limb muscles, during typical rehabilitation exercises, were assumed as an indicator of the rehabilitation progress. The mathematical model and the set of computer programs were elaborated, which enable identification of forces generated by muscles and realization of comparative analysis, within a framework of inverse dynamic problem, and with the use of optimization techniques and computer processed video-registration of limb movement. and Obsahuje seznam literatury
This paper investigates the matrix porosity and related properties of a leucocratic granite from the Krudum Massif, West Bohemia. The required samples were obtained from the 30-year old core of borehole KZ-25 (Material Documentation Depositories). In total, nine sample sets were taken from different depth levels within the borehole ranging from 18 m to 108 m. The hydraulic conductivity of the granite matrix was measured using a pressure cell whilst standard methods were employed to determine the dry density, connected porosity and total porosity. The pore size distribution was analysed using mercury porosimetry. The ultrasonic velo cities were measured using a pulse source and oscilloscope. Dynamic Young’s modulus, dynamic shear modulus, Poisson’s ratio, static Young’ s modulus, uniaxial compressive strength and moisture were determined according to measurements of ultrasonic velocities and deformability in uniaxial compression. The morphology and structure of the pore network was studied using high reso lution scanning electron microscopy. The overall porosity values defined by the different porosimetry methods follow the same trends although the absolute values differ according to the specific method. A logarithmic relationship was found to exist between hydraulic conductivity and porosity within the granite matrix. In addition, a slight depth dependence was noted in the porosity, hydraulic conductivity, bulk density, and ultrasonic velocities of the granite matrix. The SEM images have allowed precise mapping and detailed de scription of the pore network., Lucie Nováková, Karel Sosna, Milan Brož, Jan Najser and Petr Novák., and Obsahuje bibliografické odkazy
In the previous paper, a design of the special amplifier, intended for pyroelectric signal measurement, has been presented. [1] This paper presents the results, achieved using this amplifier for the measurements of signal characteristics of pyroelectric sensors in our testing lab. The amplifier is being used for the measurements connected to the solution to the specific tasks i.e.: Development of technology of spatial localization of various infrared sources, testing of infrared sources and their reliability, moistening immunity, signal-noise measurement under different condition etc. and V předcházejícím článku byl předložen návrh speciálního předzesilovače navrženého pro účely měření pyroelektrik. Tento článek předvádí výsledky dosažené za pomoci tohoto zesilovače signálu ze snímačů v naší testovací laboratoři. Zesilovač je používán pro nejrůznější měřicí úlohy, např. pro technologii prostorové lokalizace infračervených zářičů, pro testování infračervených zdrojů záření a jejich spolehlivosti, při testování odolnosti krytu snímače proti navlhání, pro měření snímače za nejrůznějších podmínek atd.
Alloxan and streptozotocin are widely used to induce experimental diabetes in animals. The mechanism of their action in B cells of the pancreas has been intensively investigated and now is quite well understood. The cytotoxic action of both these diabetogenic agents is mediated by reactive oxygen species, however, the source of their generation is different in the case of alloxan and streptozotocin. Alloxan and the product of its reduction, dialuric acid, establish a redox cycle with the formation of superoxide radicals. These radicals undergo dismutation to hydrogen peroxide. Thereafter highly reactive hydroxyl radicals are formed by the Fenton reaction. The action of reactive oxygen species with a simultaneous massive increase in cytosolic calcium concentration causes rapid destruction of B cells. Streptozotocin enters the B cell via a glucose transporter (GLUT2) and causes alkylation of DNA. DNA damage induces activation of poly ADP-ribosylation, a process that is more important for the diabetogenicity of streptozotocin than DNA damage itself. Poly ADP-ribosylation leads to depletion of cellular NAD+ and ATP. Enhanced ATP dephosphorylation after streptozotocin treatment supplies a substrate for xanthine oxidase resulting in the formation of superoxide radicals. Consequently, hydrogen peroxide and hydroxyl radicals are also generated. Furthermore, streptozotocin liberates toxic amounts of nitric oxide that inhibits aconitase activity and participates in DNA damage. As a result of the streptozotocin action, B cells undergo the destruction by necrosis., T. Szkudelski., and Obsahuje bibliografii
The changes in thermoluminescence (TL) signals induced by short-term ozone exposure of leaves are characterized by a down-shift of the peak-temperature of the TLB-band and an increase of a TL band at 55°C. We investigated the relationship of these changes to photosystem 2 (PS2) photochemistry. The changes were not only detectable in the presence of ozone, but also after irradiation of dark-adapted leaves and after aging of irradiated detached leaf segments. The opposite effect on TL, an up-shift of the peak-temperature of the B-band and the decrease of the intensity of the band at 55°C were found after infiltration of leaves with nigericin, antimycin A, and diphenyleneiodonium chloride (DPI). Propyl gallate down-shifted the peak-temperature of the B-band. 2,5-dimethyl-1,4-benzoquinone up-shifted the peak-temperature of the B-band and decreased the intensity of the 55°C band. The intensity of the 55°C band did not change significantly in the presence of oxygen in comparison to that in nitrogen atmosphere. It decreased with time of dark adaptation (50% intensity was observed after 3 h of dark adaptation at room temperature), however, it was reactivated to its initial value (at 5 min of dark adaptation) after 1 single-turnover flash. The 55°C band was not significantly changed in the presence of DCMU. Thus the ozone-induced band at 55°C is assigned to charge recombination in PS2. Changes in the electron transport chain at the acceptor side of PS2, probably related to the cyclic electron transport around photosystem 1 and/or chlororespiration, could play an important role in the increase of the 55°C band and the down-shift of the B-band. The changes at the acceptor side indicated by TL can be an ex pression of a physiological regulatory mechanism functional under stress conditions. and J. Skotnica ... [et al.].
The mode of inhibition of endplate currents by four esters of 1,1-dimethyl-3-oxybutyl phosphonic acid with different lipophilicities and molecule lengths were estimated by mathematical modeling based on previous electrophysiological data supplemented by several experiments with rhythmic stimulation. The aim was to discriminate between their receptor and non-receptor effects. It was shown that all esters have a two-component mechanism of depression: inhibition of the receptor open channel and allosteric modulation of the receptorchannel complex. The ratio of both functional components depends on the length and lipophilicity of the esters. Short and less lipophilic esters mostly act as open channel inhibitors and the rate of inhibition substantially depends on the rate of stimulation, i. e. probability of the receptor-channel opening. As the length of the ester radicals and their lipophilicity increased, these compounds were more active as allosteric receptor inhibitors, probably hindering the function of nAChRs from the lipid annulus., E. Pryazhnikov ... [et al.]., and Obsahuje seznam literatury