Originally published under title: Ravensbrück. London : Little, Brown, 2009. and On a sunny morning in May 1939 a phalanx of 800 women - housewives, doctors, opera singers, politicians, prostitutes - were marched through the woods fifty miles north of Berlin, driven on past a shining lake, then herded through giant gates. Whipping and kicking them were scores of German women guards. Their destination was Ravensbrück, a concentration camp designed specifically for women by Heinrich Himmler, prime architect of the Nazi genocide. For decades the story of Ravensbrück was hidden behind the Iron Curtain and today is still little known. Using testimony unearthed since the end of the Cold War, and interviews with survivors who have never spoken before, Helm has ventured into the heart of the camp, demonstrating for the reader in riveting detail how easily and quickly the unthinkable horror evolved.
Multiple sclerosis (MS) is one of the most common neurological diseases. This neurodegenerative autoimmune disease manifests as inflammatory and demyelinating impairment of the central nervous system (CNS). Although some studies demonstrated associations between altered steroidogenesis and pathophysiology of MS as well as the importance of steroids in the pathophysiology of MS, the knowledge concerning the steroid metabolome in female patients is limited. Hence, 51 steroids and steroid polar conjugates were measured in the serum of 12 women with MS, untreated with steroids and 6 agecorresponding female controls with the use of gas chromatography - mass spectrometry (GC-MS). The data were processed using age adjusted ANCOVA, receiver operating characteristics (ROC) analysis and orthogonal projections to latent structures (OPLS). Our data show higher levels of circulating C21 steroids including steroid modulators of ionotropic type A γ-aminobutyric acid (GABA A) receptors and glutamate receptors. Furthermore, the levels of GABAergic androsterone and 5-androsten-3β,7α,17β-triol were also higher in the female MS patients. In conclusion, the data demonstrate higher levels of circulating C21 steroids and their polar conjugates and some bioactive C19 steroids in women with MS, which may influence neuronal activity and affect the balance between neuroprotection and excitotoxicity., R. Kanceva, L. Stárka, L. Kancheva, M. Hill, M. Veliková, E. Havrdová., and Obsahuje bibliografii