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3232. The Libechov minipig as a large animal model for preclinical research in Huntington’s disease – thoughts and perspectives
- Creator:
- Schramke, S., Schubert, R., Frank, F., Wirsig, M., Fels, M., Kemper, N., Schuldenzucker, V., and Reilmann, R.
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, práce podpořená grantem, and TEXT
- Subject:
- zvířata, zvířata geneticky modifikovaná, prasata, prasata miniaturní, modely u zvířat, preklinické hodnocení léčiv, Huntingtonova nemoc, chov, bydlení zvířat, časové faktory, mozek--anatomie a histologie, velikost orgánu, experimenty na zvířatech, etika výzkumu, and sekvenční homologie
- Language:
- Czech and English
- Description:
- Large animal models to explore the safety and tolerability of novel therapeutic approaches for Huntington’s disease (HD) are in exploration to achieve higher translational reliability in future studies. Recently, a Libechov minipig has been established as one new transgenic (Tg) large animal model for HD. We here discuss the advantages and limitations in using this model in HD with regards to breeding, housing, handling, and with respect to homology to humans and ethical considerations. A group of TgHD and wild type (WT) female minipigs (n = 36) was used to gain first evidence about abovementioned aspects. It is concluded that Libechov minipigs may fulfill an important role to bridge the gap between rodents and non‑human primates in the translation to humans. and S. Schramke, R. Schubert, F. Frank, M. Wirsig, M. Fels, N. Kemper, V. Schuldenzucker, R. Reilmann
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
3233. The origins of the Second World War in Europe /
- Creator:
- Bell, P. M. H.
- Type:
- text and monografie
- Subject:
- Dějiny Evropy, politika mezinárodní, válka druhá světová (1939-1945), appeasement, světové dějiny 1918-1945, and zahraniční politika, mezinárodní vztahy
- Language:
- English
- Rights:
- unknown
3234. The politics of cultural retreat :
- Creator:
- Vushko, Iryna
- Type:
- text and monografie
- Subject:
- Dějiny zemí střední Evropy, byrokracie, dějiny politické, Habsburská monarchie, světové dějiny 1789-1918, and politické dějiny, politici
- Language:
- English
- Rights:
- unknown
3235. The possibilities of mr tractography in diagnostics of symptomatic epilepsy in children with different genesis
- Creator:
- Aminov , Khabibulla
- Format:
- electronic, electronic resource, and remote
- Type:
- model:article, article, Text, and TEXT
- Language:
- English
- Description:
- In this article the possibilities of MR tractography in symptomatic epilepsy patients have been presented. We determined the quantitative standards of numerical values of diffusion of white matter in children with symptomatic epilepsy of various etiology. In children with symptomatic epilepsy, the pathological changes of white matter were localized not only in the epileptogenic, but also in the opposite hemisphere. The regions with abnormal white matter FA and ADC values not only matched to limbic circle zones, but also to areas of intra- and interhemispheric connections uniting the frontal, temporal, parietal and occipital lobes of the brain. Determining the specific clusters of brain tracts in symptomatic epilepsy, regardless of etiology, is important to predict the prognosis of the disease and the likely possibility of cognitive impairment. The study proved that symptomatic epilepsy is characterized by a variety of changes in the white matter of the brain tracts that lead to the dissociation of certain regions of the brain, interrupting connections between cortical and subcortical regions and inhibiting the transfer of information. It can be concluded, that diffusion-weighted imaging are much more sensitive to the structural and metabolic changes occurring in the brain, in comparison with conventional MRI images., Khabibulla Aminov, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
3236. The prevalence of arterial hypertension and its risk factors toward hiv-positive persons in fergana valley
- Creator:
- Mirsaydullaev, Mirzoulugbek and Mamasaliev, Nematjon
- Format:
- electronic, electronic resource, and remote
- Type:
- model:article, article, Text, and TEXT
- Language:
- English
- Description:
- Background: The data on the prevalence of arterial hypertension (AH) in patients with HIV/AIDS vary. Even though some authors have reported higher prevalence of high blood pressure and systemic arterial hypertension in this group, compared to the prevalence of AH in subjects without infection, other studies have found similar prevalence of AH between men and women with HIV and individuals without the infection. In Uzbekistan such researches were not conducted yet. Objective: Evaluate the prevalence of prevalence of arterial hypertension and its risk factors at the HIV-positive persons of Fergana Valley of Uzbekistan. Methods:A cross-sectional study aligned to a cohort of patients with HIV/AIDS. The study considered hypertension at levels ≥ 140/90 mmHg or use of antihypertensive drugs and prehypertension at levels > 120/80 mmHg. Results: Out of this total, 138 patients (48%) were male and 149 were female (52%); 65% of them were 40 years-old or younger, and other 35% were over 40 years of age. Among the individuals evaluated, 184 (64.1%) had blood pressure within the normal range, 62 (21.6%) were considered prehypertensive, and 41 (14.3%) were considered hypertensive. Twenty five patients (61%) knew they had hypertension, and 9 of them (36.0%) used antihypertensive medication on a continuous basis. The blood pressure levels were controlled in only 5 (20.0%) patients that knew that they were hypertensive. Conclusion: Among HIV-infected persons, 21.6% were considered prehypertensive, and 14.3% were considered hypertensive. It is important to warn clinicians who provide care to HIV/AIDS patients that such patients are not only individuals infected with a potentially fatal virus, but, despite the benefit of new antiretroviral therapies, they are also patients whose prognosis may be affected by comorbidities, such as hypertension., Mirzoulugbek Mirsaydullaev, Nematjon Mamasaliev, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
3237. The Revolutions of 1989 :
- Type:
- text and monografie kolektivní
- Subject:
- Vnitropolitický vývoj, politický život, revoluce (1989), dějiny politické, and zahraniční periodika a sborníky
- Language:
- English
- Rights:
- unknown
3238. The role of patients in the management of chronic diseases: Results of the focus-group study
- Creator:
- Dimcheva, Teodora, Foreva, Gergana, Аsenova, Radost, Маteva, Nonka, Stoev, Todor, and Dimova, Rosica
- Format:
- electronic, electronic resource, and remote
- Type:
- model:article, article, Text, práce podpořená grantem, and TEXT
- Subject:
- lidé, zjišťování skupinových postojů, chronická nemoc, kvalita života, management nemoci, dlouhodobá péče, péče orientovaná na pacienta, vzdělávání pacientů jako téma, postoj ke zdraví, poskytování zdravotní péče, zdravotní gramotnost, zapojení pacienta, and plány rozvoje
- Language:
- English
- Description:
- The management of chronic diseases shall be considered a priority in the work of the global international institutions, which are related to health policies. In the search for effective and efficient solutions for the treatment of chronic diseases, scientists are developing different programs. In Bulgaria the continuous monitoring of chronically ill people is defined with the term dispensarization. The objective of the research is to analyze the place and the role of patients in the monitoring of their chronic diseases and how the concept of quality of life relates to this process. Method The research in focus groups is planned within a research project on the monitoring of chronic diseases. Five group discussions were held. The number of participants in all focus groups was sixty. Results The two discussed directions - the active role of the patient and the focus on the results are weak links in the current organization of the care for the chronically ill people. The topic of creating and adopting an Act of the patient was also presented, in which to be paid attention to the evaluation of the quality of life. In general was brought the need for a clear delineation of the roles and the competencies of everyone involved in the monitoring process of chronic diseases. The chronic disease cannot be defined only as a medical problem, as there are economic and social, including political consequences. Conclusions The management of the chronic disease requires coordination of doctor-patient interaction, a model of partnership and trust in the relations, self-management of the condition by the patients and their inclusion in the health team. The most important step to achieve this goal is the education of the patients, increasing their knowledge and motivation, psycho-emotional support, instilling hope and faith in the capacity of the patients., Teodora Dimcheva, Gergana Foreva, Radost Аsenova, Nonka Маteva, Todor Stoev, Rosica Dimova, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
3239. The study of structural changes in bone tissue of alveolar process of jaws in experimental animals after implantation of a new construction of dental implant from titanium bt-1.00 developed in Uzbekistan
- Creator:
- Khabilov, Nigman Lukmanovich, Mun, Tatyana Olegovna, Usmonov, Farkhodjon Komiljonovich, and Baybekov, Iskander Mukhamedovich
- Format:
- electronic, electronic resource, and remote
- Type:
- model:article, article, Text, and TEXT
- Language:
- English
- Description:
- The widespread introduction of dental implant in the dental practice will determine progress and the future of prosthetic dentistry. At the same time, like any new direction dental implantation has generated a lot of questions and unsolved problems. On many of these issues and problems can be answered only by using morphological methods. Therefore, after the development of a new construction of the dental implant one of the main issues was the question of its interaction with the jawbone and soft tissues of the oral cavity. We performed the experiment on 24 long snout dogs of both sexes, weighing 30-35 kg, with normal bite, at the age of 20-24 months. Animals were divided into 2 groups, according to samples of screw dental implants used in the experiment: basic group - 12 dogs in which were used samples of the new construction of dental implant “Implant.uz” (Uzbekistan); control group – 12 dogs in which were applied screw dental implant system “Dentium” (South Korea). Terms of derivation of animals from experiments were 1, 3, and 6 months. By using morphological techniques were studied implants “Implant.uz” from medical titanium BT-1.00 brand, their interaction with bone of alveolar ridge. “Implant.uz” did not cause pathological changes in the bone tissue of alveolar ridges of jaws and could be an alternative to known dental implants., Nigman Lukmanovich Khabilov, Tatyana Olegovna Mun, Farkhodjon Komiljonovich Usmonov, Iskander Mukhamedovich Baybekov, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
3240. The transformation of confessional cultures in a central European city :
- Type:
- text and monografie
- Subject:
- Křesťanské církve, sekty, denominace, města, dějiny církevní, identita náboženská, vztahy katolíci-evangelíci, české země 1306-1526, české země 1526-1792, města, obce, and církevní a náboženské dějiny
- Language:
- English
- Rights:
- unknown