In the present study, experiments were conducted in a large-scale flume to investigate the issue of local scour around side-by-side bridge piers under both ice-covered and open flow conditions. Three non-uniform sediments were used in this experimental study. Analysis of armour layer in the scour holes around bridge piers was performed to inspect the grain size distribution curves and to study the impact of armour layer on scour depth. Assessments of grain size of deposition ridges at the downstream side of bridge piers have been conducted. Based on data collected in 108 experiments, the independent variables associated with maximum scour depth were assessed. Results indicate that the densimetric Froude number was the most influential parameter on the maximum scour depth. With the increase in grain size of the armour layer, ice cover roughness and the densimetric Froude number, the maximum scour depth around bridge piers increases correspondingly. Equations have been developed to determine the maximum scour depth around bridge piers under both open flow and ice covered conditions.