Mechanická citlivost buněk: Dosud opomíjený způsob signalizace

Title:

Mechanická citlivost buněk: Dosud opomíjený způsob signalizace

Creator:

Krůšek, Jan

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:8691a0e3-4d33-44be-9145-8fa69d477cb9
uuid:8691a0e3-4d33-44be-9145-8fa69d477cb9

Type:

article, model:article, and TEXT

Description:

Mechanosensiiviy of cells-marginalized mode of signalization. Environmental sensing by living cells comprises also mechanical forces and deformations. Mechanotransduction is process of translation of such mechanical stimuli into biological signals as a change of the membrane potential or stimulations of particular intracellular signal cascades. In prokaryotes the best characterized mechanial sense is osmosensitivity, while in eukaryotes it is mechanotransduction in hair cells of the inner ear. Crowing number of evidence shows its importance also in physiology of muscle, heart and blood vessels and in pathology of tumors. Virtually all cells need mechanical stimuli and without them they cannot survive and properly differentiate. But despite substantial progress we are still lacking detailed information about identity of the primary eukaryote mechanosensors.

Language:

Czech

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Vesmír | 2010 Volume:89 (140) | Number:3

Harvested from:

CDK

Metadata only:

false