A variety of plant protection products and other agrochemicals are used in agro-ecosystems. Products approved for integrated pest management (IPM) or organic farming should have minimal negative side effects on benefi cial insects. The Asian harlequin ladybird Harmonia axyridis (Pallas, 1773) (Coleoptera: Coccinellidae) has become a widespread and important generalist predator of certain agricultural pests, mainly aphids, throughout Europe. We studied the effects of two agrochemicals, Boundary SW® (auxiliary plant protection product) and Prev B2® (foliar boron fertilizer), usually regarded as “environmentally friendly” and known to have insecticidal side effects against some fruit and vegetable pests (e.g., aphids, spider mites, weevils), on the last larval instar and adults of Harmonia axyridis. The conventional organophosphate insecticide Reldan 22® was used as a chemical standard for evaluating the lethal effect, because this product is usually effective against a broad spectrum of insects, and indeed was immediately lethal for both the adults and larvae of this species. However, whereas Prev B2® had no effect, adult ladybirds sprayed with Boundary SW® survived only for up to 25 h and also none of the larvae completed their development. Thus, although our experiments were not made under natural conditions, the use of Boundary SW® cannot be recommended for IPM and organic farming in terms of safeguarding insect predators such as Harmonia axyridis until further more detailed testing.