In the paper, an algorithm that allows to detect and reject outliers in a self-organizing map (SOM) has been proposed. SOM is used for data clustering as well as dimensionality reduction and the results obtained are presented in a special graphical form. To detect outliers in SOM, a genetic algorithm-based travelling salesman approach has been applied. After outliers are detected and removed, the SOM quality has to be estimated. A measure has been proposed to evaluate the coincidence of data classes and clusters obtained in SOM. A larger value of the measure means that the distance between centers of different classes in SOM is longer and the clusters corresponding to the data classes separate better. With a view to illustrate the proposed algorithm, two datasets (numerical and textual) are used in this investigation.
Outliers in univariate and multivariate regression models with constraints are under consideration. The covariance matrix is assumed either to be known or to be known only partially.
Based on several field research trips between 2007 and 2011, this study presents data in the neglected field of research on urban Bushmen dwellers. It describes the limited economic opportunities and coping strategies of the !Xun Bushmen living in the township Omulunga of the town Grootfontein in the north of the commercial farming area in Namibia.
Muscarinc receptor-mediated signaling takes part in many physiological functions ranging from complex higher nervous activity to vegetative responses. Specificity of action of the natural muscarinic agon ist acetylcholine is effected by action on five muscarinic receptor subtypes with particular tissue and cellular localization, and coupling preference with different G-proteins and their signalin g pathways. In addition to physiological roles it is also implicated in pathologic events like promotion of carcinoma cells growth, early pathogenesis of neurodegenerative diseases in th e central nervous system like Alzheimer's disease and Parkinson's disease, schizophrenia, intoxications resulting in drug addiction, or overactive bladder in the periphery. All of these disturbances demonstrate involvement of specific muscarinic receptor subtypes and point to the importance to develop selective pharmacotherapeutic interventions. Because of the high homology of the orthosteric binding site of muscarinic receptor subtypes there is virtually no subtype selective agonist that binds to this site. Activation of specific receptor subtypes may be achieved by developing allosteric modulators of acetylcholine binding, since ectopic binding domains on the receptor are less conserved compared to the orthosteric site. Potentiation of the effects of acetylcholine by allosteric modulators would be beneficial in cases where acetylcholine release is reduced due to pathological conditions. When presynaptic function is severly compromised, the utilization of ectopic agonists can be a thinkable solution., J. Jakubík ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy