This international conference took place in Prague on 25-30 July, 2011. Its main goal was to contribute to uncovering possible phenomenological ("quantum thermodynamic") laws governing the behavior of mesoscopic systems and also to provide better understanding and insight into recent problems of the foundations, relying on theoretical and experimental methods of condensed matter physics and quantum optics. Special attention was given to the dynamics of mesoscopic open systems and their relevance to problems of measurement of non-equilibrium quantum systems, thermal and quantum fluctuations, dissipation, noise, physics of quantum information and biological systems, in terms of both theory and experiment. Additional topics included biophysics, gravitation and cosmology. FQMT'11 was a follow-up to two previous conferences held in Prague 2004 and 2008. and Václav Špička.