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Start Over Creator Eva Syková

14. Rapid but not slow spinal cord compression elicits neurogenic pulmonary edema in the rat

Creator:
Jiří Šedý, Josef Zicha, Jaroslav Kuneš, Pavla Jendelová, and Eva Syková
Format:
print
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, fyziologie, edém, poranění míchy, krevní tlak, pulz (lékařství), krysa obecná, physiology, edema, spinal cord injuries, blood pressure, pulse, Rattus rattus, neurogenic pulmonary edema, 14, and 612
Language:
English
Description:
The development of neurogenic pulmonary edema (NPE) can be elicited by an immediate epidural balloon compression of the thoracic spinal cord. To evaluate whether a slower balloon inflation could prevent NPE development, we examined the extent of NPE in animals lesioned with a rapid (5 μl - 5 μl - 5 μl) or slow rate (3 μl - 2 μl - 2 μl - 2 μl - 2 μl - 2 μl - 2 μl) of balloon inflation. These groups were compared with the NPE model (immediate inflation to 15 μl) and with healthy controls. Slow balloon inflation prevented NPE development, whereas the pulmonary index and histology revealed a massive pulmonary edema in the group with a rapid rate of balloon inflation. Pulmonary edema was preceded by a considerable decrease in heart rate during the inflation procedure. Moreover, rapid inflation of balloon in spinal channel to either 5 μl or 10 μl did not cause NPE. Thus, a slow rate of balloon inflation in the thoracic epidural space prevents the development of neurogenic pulmonary edema, most likely due to the better adaptation of the organism to acute circulatory changes (rapid elevation of systemic blood pressure accompanied by profound heart rate reduction) during the longer balloon inflation period. It should be noted that spinal cord transection at the same level did not cause neurogenic pulmonary edema., J. Šedý ... [et al.]., and Obsahuje seznam literatury
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

15. Stem cells regenerative properties on new rat spinal fusion model

Creator:
Klíma, K., Vaněček, V., Aleš Kohout, Jiroušek, O., René Foltán, Vladimír Machoň, Gabriela Pavlíková, Pavla Jendelová, Eva Syková, and Jiří Šedý
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, animal model, rat, MSCs, bone graft substitute, spinal fusion, 14, and 612
Language:
English
Description:
Stem cells biology is one of the most frequent topic of physiological research of today. Spinal fusion represents common bone biology challenge. It is the indicator of osteoinduction and new bone formation on ectopic model. The purpose of this study was to establish a simple model of spinal fusion based on a rat model including verification of the possible use of titanium microplates with hydroxyapatite scaffold combined with human bone marrow-derived mesenchymal stem cells (MSCs). Spinous processes of two adjacent vertebrae were fixed in 15 Wistar rats. The space between bony vertebral arches and spinous processes was either filled with augmentation material only and covered with a resorbable collagen membrane (Group 1), or filled with augmentation material loaded with 5 × 10 6 MSCs and covered with a resorbable collagen membrane (Group 2). The rats were sacrificed 8 weeks after the surgery. Histology, histomorphometry and micro-CT were performed. The new model of interspinous fusion was safe, easy, inexpensive, with zero mortality. We did not detect any substantial pathological changes or tumor formation after graft implantation. We observed a nonsignificant effect on the formation of new bone tissue between Group 1 and Group 2. In the group with MSCs (Group 2) we described mino r inflamatory response which indicates the imunomodulational and antiinflamatory role of MSCs. In conclusion, this new model proved to be easy to use in small animals like rats., K. Klíma, V. Vaněček, A. Kohout, O. Jiroušek, R. Foltán, J. Štulík, V. Machoň, G. Pavlíková, P. Jendelová, E. Syková, J. Šedý., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

16. Trendy v regeneraci a léčbě CNS

Creator:
Eva Syková and Pavla Jendelová
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Věda. Všeobecnosti. Základy vědy a kultury. Vědecká práce, centrální nervový systém, terapie, konference, biomedicína, central nervous system, therapy, conferences, biomedicine, Česko, Czechia, 12, and 00
Language:
Czech
Description:
Eva Syková, Pavla Jendelová.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

17. Tři otázky pro ředitele ústavů AV ČR, veřejných výzkumných institucí

Creator:
Luděk Frank, Zbyněk Jaňour, Zdeněk Chára, Řídký, Jan, Jan Kopečný, Eva Syková, Jan Zima, Lubomír, Lízal, and Malý, Jiří
Format:
print
Type:
article, články, model:article, and TEXT
Subject:
Věda. Všeobecnosti. Základy vědy a kultury. Vědecká práce, Akademie věd České republiky, vědecké ústavy, research institutions, 12, and 00
Language:
Czech
Description:
This month we continue with the comments of the directors of all the Academy institutes, who were asked these three questions: In which direction they will lead the development of their institutes? What are they doing to achieve excellence in science? Can they evaluate the work in accordance with the new statutes called Public Research Institution?
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

18. Věda a vzdělanostní společnost

Creator:
Eva Syková
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Věda. Všeobecnosti. Základy vědy a kultury. Vědecká práce, věda a společnost, vzdělanost, vědecké instituce a organizace, science and society, educational attainment, scientific institutions and organizations, vzdělanostní společnost, science centra, knowledge society, science centers, 12, and 00
Language:
Czech
Description:
Západní společnost stojí na vědě, přesněji řečeno na novověké vědě, která zkoumá přírodní zákonitosti pomocí experimentů. Vědecká metoda a vědecké poznání nám umožnily přetvořit svět do jeho nynější podoby. Není téměř žádný aspekt našeho každodenního života, který by věda nějakým způsobem neovlivnila. and Eva Syková.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public