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Start Over Creator Jaroslav Kuneš Format svazek Subject Fyziologie člověka a srovnávací fyziologie Subject blood pressure Harvested from CDK

1. Influence of active immunization against angiotensin AT1 or AT2 receptor on hypertension development in young and adult SHR

Creator:
Blanka Železná, Leopold Veselský, Jiří Velek, Zdena Dobešová, Josef Zicha, and Jaroslav Kuneš
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, krevní tlak, hypertrofie srdce, blood pressure, heart hypertrophy, spontaneously hypertensive rats, active immunization, angiotensin AT1 receptor, angiotensin AT2 receptor, kidney weight, 14, and 612
Language:
English
Description:
B. Železná, L. Veselský, J. Velek, Z. Dobešová, J. Zicha, J. Kuneš. and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

2. The effects of pertussis toxin-treatment on integrated vasoactive response of vascular system in spontaneously hypertensive rats

Creator:
Soňa Čačányiová, Kristek, F., Jaroslav Kuneš, and Josef Zicha
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, fyziologie, krevní tlak, acetylcholin, physiology, blood pressure, acetylcholine, spontaneously hypertensive rats (SHR), pertussis toxin, noradrenaline, bradykinin, vasoactive responses, 14, and 612
Language:
English
Description:
We investigated the effect of pertussis toxin (PTX) on hypotensive response induced by acetylcholine (ACh) and bradykinin (BK) and on noradrenaline (NA)-induced pressor response in spontaneously hypertensive rats (SHR). Fifteen-week-old Wistar rats and age-matched SHR were used. Half of SHR received PTX (10 μg/kg/i.v.) and the experiments were performed 48 h later. After the anesthesia the right carotid artery was cannulated in order to record blood pressure (BP). The hypotensive response to ACh was enhanced in SHR compared to Wistar rats. After pretreatment of SHR with PTX the hypotensive response to ACh was reduced compared to untreated SHR and it was also diminished in comparison to Wistar rats. Similarly, the hypotensive response to BK was also decreased after PTX pretreatment. The pressor response to NA was increased in SHR compared to Wistar rats. NA-induced pressor response was considerably decreased after PTX pretreatment compared to untreated SHR. In conclusion, the enhancement of hypotensive and pressor responses in SHR was abolished after PTX pretreatment. Our results suggested that the activation of PTX-sensitive inhibitory Gi proteins is involved in the regulation of integrated vasoactive responses in SHR and PTX pretreatment could be effectively used for modification of BP regulation in this type of experimental hypertension., S. Čačányiová, F. Kristek, J. Kuneš, J. Zicha., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public