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2. Endometrióza u adolescentiek

Creator:
Nižňanská, Zuzana, Korbeľ, Miroslav, and Redecha, Martin
Type:
model:article, article, Text, and TEXT
Subject:
endometrióza--DIAGNÓZA--ETIOLOGIE--TERAPIE, progrese nemoci--PREVENCE A KONTROLA, farmakoterapie--METODY, gynekologické chirurgické výkony, ženská infertilita--ETIOLOGIE--PREVENCE A KONTROLA, lidé, mladiství, and ženské pohlaví
Language:
Czech and Slovak
Description:
Zuzana Nižňanská, Miroslav Korbeľ, Martin Redecha and Lit: 15
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

5. PTEN mutations as predictive marker for the high-grade endometrial cancer development in Slovak women

Creator:
Gbelcová, Helena, Gergely, Lajos, Šišovský, Vladimír, Straka, Ľubomír, Böhmer, Daniel, Pastoráková, Andrea, Sušienková, Katarína, Repiská, Vanda, Korbeľ, Miroslav, Danihel, Ľudovít, and Priščáková, Petra
Format:
počítač and online zdroj
Type:
model:article and TEXT
Subject:
endometrial hyperplasia, endometrial carcinoma, PTEN, sequencing, and immunohistochemistry
Language:
English
Description:
Endometrial carcinoma (ECa) is one of the most common neoplasia of the female genital tract. The phosphatase and tensin (PTEN) homolog is the most frequently mutated tumor suppressor gene in endometrial carcinoma. PTEN encodes a phosphatase, a key regulatory enzyme involved in a signal transduction pathway that regulates cell growth, migration and apoptosis. The study evaluates an association between the morphological appearance of endometrial hyperplasia and ECa, and the presence of PTEN variations, PTEN protein level and intracellular localization. A total of 67 archived formalin-fixed and paraffin-embedded human biopsy tissue specimens with normal proliferative and secretory endometrium, endometrial hyperplasia without atypia and endometrial atypical hyperplasia, endometrioid the grade G1 and G3 and serous subtype of ECa were evaluated by sequencing for the presence of mutations in coding regions of PTEN gene of endometrial epithelial cells. The PTEN gene expression and intercellular localization of PTEN protein were evaluated immunohistochemically by immunoreactive score (IRS). PTEN mutation spectrum in endometrial carcinoma was identified for Slovak population. Twenty-eight non-silent mutations were identified in PTEN, twelve of them being novel, not annotated in Catalogue of Somatic Mutations in Cancer. Higher frequency of PTEN mutations was observed in serous carcinoma compared to global average. No correlation was observed between samples IRS, PTEN cellular localization and identified mutations. PTEN sequencing can be beneficial for patients considering prognosis of disease and sensitivity to treatment.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

6. Výskyt chlamýdiovej infekcie u dievčat v detskom a adolescentnom veku

Creator:
Nižňanská, Zuzana, Korbeľ, Miroslav, and Redecha, Martin
Type:
model:article, article, Text, and TEXT
Subject:
dítě, mladiství, chlamydiové infekce--DIAGNÓZA--KOMPLIKACE, ženská infertilita, Chlamydia trachomatis--IZOLACE A PURIFIKACE, lidé, and ženské pohlaví
Language:
Czech and Slovak
Description:
Zuzana Nižňanská, Miroslav Korbeľ, Martin Redecha and Lit: 12
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

7. Výskyt Gardnerella vaginalis u dievčat v detskom a adolescentnom veku

Creator:
Nižňanská, Zuzana, Korbeľ, Miroslav, and Redecha, Martin
Type:
model:article, article, Text, and TEXT
Subject:
dítě, mladiství, Gardnerella vaginalis--IZOLACE A PURIFIKACE--MIKROBIOLOGIE, bakteriální vaginóza--DIAGNÓZA--TERAPIE, lidé, and ženské pohlaví
Language:
Czech and Slovak
Description:
Zuzana Nižňanská, Miroslav Korbeľ, Martin Redecha and Lit: 8
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

8. Vývojové chyby u reprodukčných strát v 1. trimestri gravidity

Creator:
Vojtaššák, Ján, Malová, J., Demjénová, Ľudmila, Korbeľ, Miroslav, and Martanovič, P.
Type:
model:article, article, Text, kongresy, and TEXT
Subject:
potrat spontánní--etiologie, první trimestr těhotenství, vrozené vady, cytodiagnostika, and potracený plod--patologie
Language:
Czech and Slovak
Description:
Ján Vojtaššák, J. Malová, Ľ. Demjénová
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public