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2. The effect of quercetin on light-induced cytotoxicity of hypericin
- Creator:
- Andrej Miroššay, Onderková, H., Ladislav Mirossay, Šarišský, M., and Ján Mojžiš
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, hypericin, quercetin, cell line, oxygen radicals, cytotoxic activity, 14, and 612
- Language:
- English
- Description:
- Protective effect of quercetin, a natural antioxidant compound, on hypericin-induced cytotoxicity was studied in human promyelocytic leukemia cells (HL-60). Hypericin (10-5 mol.l-1) alone significantly decreased cell survival to 21 % that found in the controls, whereas in combination with quercetin (10-5 mol.l-1) this decrease was diminished to 46 %. Lower concentrations of quercetin had no protective effect. These findings indicate that oxygen radicals can play an important role in hypericin-induced phototoxic effects., A. Miroššay, H. Onderková, L. Mirossay, M. Šarišský, J. Mojžiš., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public