Search

Start Over Creator Mlynarčíková, A. Subject progesteron

1. Components of cigarette smoke inhibit expansion of oocyte-cumulus complexes from porcine follicles

Creator:
Vršanská, S., Eva Nagyová, Mlynarčíková, A., Mária Ficková, and Jaroslav Kolena
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, kyselina hyaluronová, progesteron, hyaluronic acid, progesterone, porcine ovary, cigarette alkaloids, cumulus expansion, 14, and 612
Language:
English
Description:
The role of alkaloids in cigarette smoke was investigated in the cumulus expansion of oocyte-cumulus complexes (OCC) isolated from large antral porcine follicles. Suppression of the cumulus expansion stimulated by FSH was observed in the presence of different concentration of cadmium, anabasine and nicotine but not its metabolite cotinine. There were comparable inhibitory effects of cadmium and nicotine on the synthesis and accumulation of hyaluronic acid in the cell/matrix compartment of OCC. The inhibitory effect of tested compounds on the cumulus expansion was accompanied by decreased progesterone synthesis by cumulus cells during 42 h incubation of OCC with FSH. The results suggest that cigarette smoking may affect intrafollicular processes, which are responsible for normal ovulation and fertilization., S. Vršanská, E. Nagyová, A. Mlynarčíková, M. Ficková, J. Kolena., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public